Phytonadione

Pronunciation

Generic Name: phytonadione (fye-toe-na-DYE-one)
Brand Name: Generic only. No brands available.

Severe and sometimes fatal reactions have occurred after injection of phytonadione into the vein or muscle. These reactions often resemble severe allergic reactions, including shock and severe heart and/or breathing problems. Some patients have experienced these reactions after receiving phytonadione for the first time. Phytonadione should only be injected into the vein or muscle in situations in which it cannot be injected under the skin and the benefits outweigh the risks.


Phytonadione is used for:

Treating bleeding problems caused by low vitamin K blood levels or decreased vitamin K activity (eg, caused by certain anticoagulants, antibiotics, salicylates, other medicines, certain diseases that decrease absorption or production of vitamin K). It may also be used to treat or prevent certain bleeding problems (hemorrhagic disease) in newborns.

Phytonadione is a vitamin K. It works by helping the liver to produce blood clotting factors.

Do NOT use phytonadione if:

  • you are allergic to any ingredient in phytonadione

Contact your doctor or health care provider right away if any of these apply to you.

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Before using phytonadione:

Some medical conditions may interact with phytonadione. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney problems

Some MEDICINES MAY INTERACT with phytonadione. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) because effectiveness may be decreased by phytonadione

This may not be a complete list of all interactions that may occur. Ask your health care provider if phytonadione may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use phytonadione:

Use phytonadione as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Phytonadione is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using phytonadione at home, carefully follow the injection procedures taught to you by your health care provider.
  • If phytonadione contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • Do not take large doses of vitamins (megadoses or megavitamin therapy) while taking phytonadione unless directed by your doctor.
  • If you miss a dose of phytonadione, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use phytonadione.

Important safety information:

  • Phytonadione may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to phytonadione. Using phytonadione alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using phytonadione.
  • Phytonadione contains benzyl alcohol, which has been reported to cause toxic reactions in newborn children. Benzyl alcohol has also been associated with a serious and sometimes fatal reaction called "gasping syndrome" in premature infants. Discuss any questions or concerns with your doctor.
  • LAB TESTS, including blood clotting tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Caution is advised when using phytonadione in premature and newborn CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: It is unknown if phytonadione can cause harm to the fetus. If you become pregnant while taking phytonadione, discuss with your doctor the benefits and risks of using phytonadione during pregnancy. It is unknown if phytonadione is excreted in breast milk. If you are or will be breast-feeding while you are using phytonadione, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of phytonadione:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Flushing sensations; pain, swelling, or tenderness at the injection site; "peculiar" taste sensations.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue tinge to the skin, fingernails, or toenails; fast or weak pulse; severe dizziness; shortness of breath; skin lesions; yellowing of the skin or eyes in newborn children.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of phytonadione:

Phytonadione is usually handled and stored by a health care provider. If you are using phytonadione at home, store phytonadione as directed by your pharmacist or health care provider.

General information:

  • If you have any questions about phytonadione, please talk with your doctor, pharmacist, or other health care provider.
  • Phytonadione is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take phytonadione or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about phytonadione. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to phytonadione. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using phytonadione.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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