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Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Pamprin Maximum Pain, Triplex AD, Midol Maximum Strength Menstrual, Midol PMS, Pamprin Multi-Symptom Menstrual Relief, Pyril D, Codituss DM, Midol PMS Maximum Strength, Poly Hist Forte (old formulation), Aldex D, Show all 158 »Neo AC, Resperal, Dermagesic, Tritan, K-Tan, Ryna-12, Rhinatate, Atrohist Pediatric, Premsyn PMS, Menstrual Relief, Codimal PH, De-Chlor MR, Hydrophene DH, Covangesic, PMS Relief, Syncol, Viravan-P, Aldex DM, Poly Hist DHC, Codal-DH Syrup, Hyco-DH, Tannate V DM, Dicomal-DH, Hycomal DH, Mintuss MR, Poly Hist HC, Delhist D, Tussplex, Trimal DH, PhendaCof Plus, Codituss DH, Viravan-PDM, Capron DM, Pyril DM, A-Tan 12X, Ryna-12X, Reme Hist DM, MyHist-DM, Rolatuss with Hydrocodone, Deconsal DM, Multihistamine-D, Vetuss HC Syrup, Ru-Tuss with Hydrocodone, Ru-Hist Plus, Iohist D, Pyril Mal Phenyl HCl, Ru-Hist D, R-Tannic-S A/D, K-Tan 4, Viravan-T, Myci Spray, Deconsal CT, Pyril Tann-12, Viravan-S, Pyrlex PD, Ryna-12S, Pyrlex, Rynesa 12S, Deconsal CT Tannate, V-Tann, Ry-T-12, Tri-Histine, Poly-Histine, Metahistine D, Polytine D, Trihist-D, Prohistine-D, Poly-Histine-D, Poly-D, Delhistine D, Liqui-Histine-D, KG-Hist D, Quadra-Hist D Pediatric, Quadra-Hist D, Liqui-Minic Infant, Uni-Multihist D Ped, Codimal DM, Histine-D, Multihistamine-D Ped, P-Hist, Triotann-S Pediatric, Tanoral Pediatric, Equitan Pediatric, R-Tannamine Pediatric, Triotann-S, Gelhist Pediatric, R-Tannate, Triple Tannate Pediatric, Tri-Tannate, Tanamine, R-Tannamine, Tanoral, Url-Tannate Pediatric, Rhinatate Pediatric, Tanamine Pediatric, Tri-Tannate Pediatric, R-Tannate Pediatric, Rynatan-S Pediatric, Tussi-12D S, C-Tanna 12D, Tannihist-12D, Z-Xtra, PMS Formula Multi-Symptom, Menstrual Complete, Menstrual PMS, Tannate 12D S, Tussi-12D, Histalet Forte, Vanex Forte, Pro-Chlo, Pyrlex CB, Zotex-D, Corzall Plus, URL-Tannate, Triotann, Poly Tan D, Poly Tan, Coryza-DM, Poly Tan DM, Pro-Clear AC, Pro-Red AC, Dicomal-PH, ProHist, Nalfrx, Deconsal DM Tannate, Viratan-DM, Zotex-12, V-Tan DM, Codal-DM Syrup, Viravan-DM, Zotex-C, MyHist-PD, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Triotann Pediatric, Phena-S, Ru-Hist Forte, Histatan, Phena-Plus, Tri Tann Pediatric, Poly Hist PD (old formulation), Phena-S 12, Pyrichlor PE, Conal, Nalex A 12, AllerTan, Triplex DM

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Pyrilamine Identification

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Administrative Information

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Last Revision Date



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