Pyrilamine use while Breastfeeding
Drugs containing Pyrilamine: Resperal, Pyril D, Midol Maximum Strength Menstrual, Menstrual Relief, Aldex D, Poly Hist Forte, Midol PMS, Triplex AD, Midol PMS Maximum Strength, Ru-Hist D, Show all 158 »Pamprin Multi-Symptom Menstrual Relief, Tritan, Poly Hist PD, Menstrual Complete, Pyrlex, Phena-S, Chlorex-A 12, Conal, Pro-Red AC, Rynesa 12S, Nalex A 12, Tanoral, Tanamine, Ru-Hist Forte, Pamprin Maximum Pain, Z-Xtra, Viravan-PDM, Syncol, C-Tanna 12D, Tussi-12D, Triplex DM, Codituss DM, MyHist-DM, Pyril DM, Codituss DH, De-Chlor MR, Delhist D, Hydrophene DH, Codal-DH Syrup, Mintuss MR, PhendaCof Plus, Tussplex, Trimal DH, Multihistamine-D, Multihistamine-D Ped, Hyco-DH, Reme Hist DM, Ryna-12X, Poly Hist DHC, A-Tan 12X, Rolatuss with Hydrocodone, Poly-D, Vetuss HC Syrup, Poly Hist HC, Hycomal DH, Tannate V DM, Ru-Tuss with Hydrocodone, Ru-Hist Plus, Dicomal-DH, Quadra-Hist D, Ryna-12, R-Tannic-S A/D, Pyril Tann-12, K-Tan, K-Tan 4, Deconsal CT, Viravan-T, Viravan-S, V-Tann, Pyril Mal Phenyl HCl, Viravan-P, Myci Spray, Pyrlex PD, Ry-T-12, Deconsal CT Tannate, Ryna-12S, Tri-Histine, Trihist-D, Liqui-Histine-D, Polytine D, Metahistine D, Poly-Histine-D, Prohistine-D, KG-Hist D, Iohist D, Viratan-DM, Poly-Histine, Quadra-Hist D Pediatric, Liqui-Minic Infant, Histine-D, Uni-Multihist D Ped, Delhistine D, Coryza-DM, R-Tannate, Triotann-S, R-Tannamine Pediatric, Gelhist Pediatric, R-Tannate Pediatric, Atrohist Pediatric, Rynatan-S Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Tanamine Pediatric, Tri-Tannate, Equitan Pediatric, Triple Tannate Pediatric, Phena-Plus, Vanex Forte, PMS Formula Multi-Symptom, Dermagesic, PMS Relief, Menstrual PMS, Covangesic, Premsyn PMS, Tannate 12D S, Tussi-12D S, Pro-Chlo, Histalet Forte, Pyrlex CB, Zotex-D, Tannihist-12D, Corzall Plus, Rhinatate, Url-Tannate Pediatric, ProHist, P-Hist, Nalfrx, Poly Tan, Poly Tan D, Pro-Clear AC, Poly Tan DM, Deconsal DM, Codimal DM, Zotex-12, Deconsal DM Tannate, Poly Hist DM, V-Tan DM, Codal-DM Syrup, Viravan-DM, Neo AC, Dicomal-PH, Triotann Pediatric, Tri-Gestan S, Histatan, Triotann, R-Tannamine, URL-Tannate, Tri-Hist Pediatric, Tri Tann Pediatric, Codimal PH, Zotex-C, Phena-S 12, Pyrichlor PE, AllerTan, MyHist-PD, Aldex DM
Pyrilamine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third. No studies using modern assay methods have been reported.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.
Possible Effects on Lactation
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.
Alternate Drugs to Consider
1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.
2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.