Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Midol Maximum Strength Menstrual, Triplex AD, Pamprin Multi-Symptom Menstrual Relief, Midol PMS, Pamprin Maximum Pain, Aldex D, Ru-Hist D, Pyril D, Resperal, Poly-Histine-D, Show all 158 »R-Tannamine, Syncol, Midol PMS Maximum Strength, R-Tannate, Atrohist Pediatric, Ru-Hist Forte, Poly Hist Forte (old formulation), Tritan, Covangesic, Trimal DH, De-Chlor MR, Codal-DH Syrup, Poly Tan D, Pro-Red AC, Ryna-12, Poly Hist DHC, Menstrual Relief, Codituss DM, Codal-DM Syrup, Zotex-D, Codimal DM, Hydrophene DH, Hyco-DH, Dicomal-DH, Hycomal DH, Codituss DH, Mintuss MR, Delhist D, Ru-Hist Plus, PhendaCof Plus, Tussplex, Poly Hist HC, Viravan-PDM, Capron DM, Reme Hist DM, MyHist-DM, Pyril DM, Rolatuss with Hydrocodone, Ru-Tuss with Hydrocodone, Multihistamine-D, Tannate V DM, A-Tan 12X, Vetuss HC Syrup, Ryna-12X, Iohist D, K-Tan, R-Tannic-S A/D, Pyril Tann-12, K-Tan 4, Viravan-T, Ryna-12S, Deconsal CT, Viravan-S, V-Tann, Pyril Mal Phenyl HCl, Viravan-P, Pyrlex, Pyrlex PD, Rynesa 12S, Ry-T-12, Deconsal CT Tannate, Myci Spray, Tri-Histine, Polytine D, Trihist-D, Liqui-Histine-D, Metahistine D, Prohistine-D, Poly-D, Delhistine D, KG-Hist D, Triplex DM, Quadra-Hist D, Poly-Histine, Quadra-Hist D Pediatric, Liqui-Minic Infant, Histine-D, Uni-Multihist D Ped, Multihistamine-D Ped, Coryza-DM, R-Tannate Pediatric, Gelhist Pediatric, Triotann-S, Rynatan-S Pediatric, Phena-Plus, Phena-S, Chlorex-A 12, R-Tannamine Pediatric, Triotann-S Pediatric, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Tri-Tannate, Triple Tannate Pediatric, Tanoral Pediatric, Equitan Pediatric, Vanex Forte, Histalet Forte, PMS Formula Multi-Symptom, Dermagesic, Z-Xtra, PMS Relief, Menstrual PMS, Menstrual Complete, Premsyn PMS, Tannate 12D S, Tussi-12D, Pyrlex CB, Pro-Chlo, Corzall Plus, Tannihist-12D, Tussi-12D S, C-Tanna 12D, Rhinatate, Url-Tannate Pediatric, Poly Tan DM, Poly Tan, ProHist, Pro-Clear AC, Neo AC, Zotex-C, Dicomal-PH, P-Hist, Nalfrx, Deconsal DM Tannate, Aldex DM, Zotex-12, V-Tan DM, Deconsal DM, Viravan-DM, Codimal PH, Phena-S 12, Histatan, Triotann Pediatric, Tri-Gestan S, Triotann, URL-Tannate, Tanamine, Tanoral, Tri-Hist Pediatric, Tri Tann Pediatric, MyHist-PD, Pyrichlor PE, Conal, AllerTan, Poly Hist PD (old formulation), Nalex A 12, Viratan-DM

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Possible Effects on Lactation

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Pyrilamine Identification

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CAS Registry Number


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Administrative Information

LactMed Record Number


Information from the National Library of Medicine's LactMed Database.

Last Revision Date



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