Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Triplex AD, Midol Maximum Strength Menstrual, Poly Hist Forte, Midol PMS, Pamprin Multi-Symptom Menstrual Relief, Ru-Hist D, Pamprin Maximum Pain, Aldex D, Triplex DM, Resperal, Show all 158 »Tussi-12D, Viravan-T, Pyril D, Codituss DH, Menstrual PMS, Syncol, Phena-Plus, Delhistine D, Hydrophene DH, Tanoral, Pro-Clear AC, Poly Hist PD, Tri-Tannate, Ru-Hist Forte, Codituss DM, Reme Hist DM, PMS Relief, Zotex-D, Codimal DM, Pyrlex, Midol PMS Maximum Strength, Dicomal-DH, Poly Hist HC, Hyco-DH, Hycomal DH, Trimal DH, Tussplex, PhendaCof Plus, Aldex DM, Mintuss MR, De-Chlor MR, Codal-DH Syrup, Ru-Tuss with Hydrocodone, A-Tan 12X, Ru-Hist Plus, Delhist D, Viravan-PDM, Poly Hist DHC, Pyril DM, MyHist-DM, Vetuss HC Syrup, Ryna-12X, Rolatuss with Hydrocodone, Tannate V DM, Viratan-DM, Histine-D, Ryna-12, R-Tannic-S A/D, Pyril Tann-12, K-Tan, K-Tan 4, Ryna-12S, Deconsal CT, Viravan-S, V-Tann, Myci Spray, Pyril Mal Phenyl HCl, Viravan-P, Pyrlex PD, Rynesa 12S, Ry-T-12, Deconsal CT Tannate, Tri-Histine, Poly-Histine, Metahistine D, Polytine D, Trihist-D, Prohistine-D, Poly-Histine-D, Multihistamine-D Ped, Poly-D, Liqui-Histine-D, KG-Hist D, Quadra-Hist D Pediatric, Quadra-Hist D, Liqui-Minic Infant, Uni-Multihist D Ped, Iohist D, Deconsal DM Tannate, Multihistamine-D, Coryza-DM, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannate Pediatric, Rynatan-S Pediatric, Chlorex-A 12, Atrohist Pediatric, R-Tannamine Pediatric, Triotann-S Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Tanamine Pediatric, Triple Tannate Pediatric, Tanoral Pediatric, Equitan Pediatric, Phena-S, Vanex Forte, PMS Formula Multi-Symptom, Dermagesic, Z-Xtra, Premsyn PMS, Covangesic, Menstrual Complete, Menstrual Relief, Tannate 12D S, Tussi-12D S, Pro-Chlo, Histalet Forte, Pyrlex CB, Corzall Plus, C-Tanna 12D, Tannihist-12D, Rhinatate, Url-Tannate Pediatric, Poly Tan DM, Poly Tan D, Poly Tan, Neo AC, Pro-Red AC, Zotex-C, Dicomal-PH, ProHist, P-Hist, V-Tan DM, Poly Hist DM, Viravan-DM, Codal-DM Syrup, Nalfrx, Deconsal DM, Codimal PH, Phena-S 12, Triotann, Histatan, Triotann Pediatric, URL-Tannate, R-Tannamine, Tritan, Tanamine, Tri-Gestan S, Tri-Hist Pediatric, MyHist-PD, Pyrichlor PE, Conal, AllerTan, Tri Tann Pediatric, Nalex A 12, Zotex-12

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Possible Effects on Lactation

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Pyrilamine Identification

Substance Name

Pyrilamine

CAS Registry Number

91-84-9

Drug Class

Administrative Information

LactMed Record Number

232

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2014-01-16

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide
(web1)