Pyrilamine use while Breastfeeding
Drugs containing Pyrilamine: Midol PMS, Resperal, Triplex AD, Poly Hist Forte (old formulation), Pamprin Maximum Pain, Premsyn PMS, Menstrual Relief, Poly-Histine-D, Phena-S, Chlorex-A 12, Show all 160 »Midol Maximum Strength Menstrual, Zotex-D, Poly Hist PD (old formulation), Ru-Hist Forte, ProHist, Ninjacof, Poly Hist DHC, Nalex A 12, Triplex DM, Pyril D, Midol PMS Maximum Strength, Pamprin Multi-Symptom Menstrual Relief, Aldex D, Dermagesic, Capron DM, Tannate 12D S, Tanamine, Menstrual PMS, Hydrophene DH, Hyco-DH, Codal-DH Syrup, Mintuss MR, Delhist D, Multihistamine-D, Multihistamine-D Ped, Poly Hist HC, Tussplex, De-Chlor MR, Dicomal-DH, Trimal DH, Codituss DH, Rolatuss with Hydrocodone, Ru-Hist Plus, Deconsal DM, Tannate V DM, MyHist-DM, Reme Hist DM, Pryil DM, Viravan-PDM, Ryna-12X, Vetuss HC Syrup, PhendaCof Plus, Ru-Tuss with Hydrocodone, Poly-D, A-Tan 12X, Hycomal DH, Liqui-Minic Infant, R-Tannic-S A/D, Pyril Tann-12, Viravan-S, Pyril Mal Phenyl HCl, Ryna-12, K-Tan 4, K-Tan, V-Tann, Ry-T-12, Ru-Hist D (old formulation), Viravan-P, Pyrlex, Ryna-12S, Pyrlex PD, Deconsal CT Tannate, Rynesa 12S, Viravan-T, Deconsal CT, Liqui-Histine-D, KG-Hist D, Iohist D, Trihist-D, Polytine D, Prohistine-D, Metahistine D, Histine-D, Uni-Multihist D Ped, Tri-Histine, Myci Spray, Poly-Histine, Quadra-Hist D, Codituss DM, Quadra-Hist D Pediatric, Delhistine D, Coryza-DM, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, R-Tannate, Gelhist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Tanoral Pediatric, Equitan Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tri-Tannate Pediatric, Tanamine Pediatric, Triple Tannate Pediatric, Tri-Tannate, Atrohist Pediatric, Vanex Forte, PMS Formula Multi-Symptom, PMS Relief, Z-Xtra, Syncol, Covangesic, Menstrual Complete, Ninjacof-A, Tussi-12D S, C-Tanna 12D, Pro-Chlo, Histalet Forte, Pyrlex CB, Corzall Plus, Tannihist-12D, Tussi-12D, Tritan, R-Tannamine, Poly Tan D, Poly Tan, P-Hist, Poly Tan DM, Pro-Clear AC, Dicomal-PH, Neo AC, Nalfrx, Codal-DM Syrup, Aldex DM, Viratan-DM, Deconsal DM Tannate, Zotex-12, Viravan-DM, V-Tan DM, Pro-Red AC (old formulation), Codimal PH, Triotann Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Histatan, Triotann, Tanoral, URL-Tannate, Phena-Plus, Tri Tann Pediatric, MyHist-PD, Zotex-C, Phena-S 12, Pyrichlor PE, AllerTan, Conal, Codimal DM
Pyrilamine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third. No studies using modern assay methods have been reported.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.
Alternate Drugs to Consider
1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.
2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.