Pyrilamine use while Breastfeeding
Drugs containing Pyrilamine: Midol Maximum Strength Menstrual, Triplex AD, Midol PMS, Poly Hist Forte, Pyril D, Ru-Hist D, Menstrual Relief, Pamprin Multi-Symptom Menstrual Relief, Aldex D, Resperal, Show all 158 »Triplex DM, Midol PMS Maximum Strength, Menstrual Complete, Viravan-T, Pyrlex, Tritan, Pro-Clear AC, Pro-Red AC, Tanamine, Hydrophene DH, Tanoral, Delhistine D, Phena-Plus, Syncol, Tussi-12D, Menstrual PMS, Pamprin Maximum Pain, Codal-DH Syrup, Poly Hist HC, Dicomal-DH, Hycomal DH, Hyco-DH, De-Chlor MR, PhendaCof Plus, Delhist D, Tussplex, Trimal DH, Mintuss MR, Codituss DH, Vetuss HC Syrup, Viravan-PDM, Ru-Hist Plus, Poly Hist DHC, Multihistamine-D, A-Tan 12X, Rolatuss with Hydrocodone, Pyril DM, Ru-Tuss with Hydrocodone, Viratan-DM, Aldex DM, Tannate V DM, MyHist-DM, Reme Hist DM, Ryna-12X, Histine-D, R-Tannic-S A/D, Pyril Tann-12, Viravan-S, Ryna-12, K-Tan, Deconsal CT, K-Tan 4, V-Tann, Ry-T-12, Pyril Mal Phenyl HCl, Viravan-P, Myci Spray, Pyrlex PD, Deconsal CT Tannate, Rynesa 12S, Ryna-12S, Tri-Histine, Polytine D, Trihist-D, Liqui-Histine-D, Metahistine D, Prohistine-D, Poly-D, Poly-Histine-D, KG-Hist D, Iohist D, Quadra-Hist D, Poly-Histine, Quadra-Hist D Pediatric, Liqui-Minic Infant, Deconsal DM Tannate, Uni-Multihist D Ped, Multihistamine-D Ped, Coryza-DM, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Rynatan-S Pediatric, Atrohist Pediatric, Phena-S, Chlorex-A 12, Triotann-S, R-Tannamine Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Triple Tannate Pediatric, Equitan Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Ru-Hist Forte, Vanex Forte, Dermagesic, Z-Xtra, Tannate 12D S, PMS Formula Multi-Symptom, PMS Relief, Covangesic, Premsyn PMS, Tussi-12D S, C-Tanna 12D, Pro-Chlo, Histalet Forte, Pyrlex CB, Zotex-D, Tannihist-12D, Corzall Plus, Rhinatate Pediatric, Rhinatate, Poly Tan D, Poly Tan, ProHist, Poly Tan DM, Neo AC, Zotex-C, Dicomal-PH, P-Hist, Nalfrx, Viravan-DM, V-Tan DM, Poly Hist DM, Codal-DM Syrup, Codituss DM, Deconsal DM, Codimal DM, Codimal PH, Phena-S 12, Histatan, Triotann Pediatric, Tri-Gestan S, Triotann, URL-Tannate, Url-Tannate Pediatric, R-Tannamine, Tri-Hist Pediatric, Tri Tann Pediatric, MyHist-PD, Pyrichlor PE, Conal, AllerTan, Poly Hist PD, Nalex A 12, Zotex-12
Pyrilamine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third. No studies using modern assay methods have been reported.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.
Possible Effects on Lactation
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.
Alternate Drugs to Consider
1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.
2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
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