Because of the relatively high levels in milk and a previous report with theophylline, occasional stimulant effects in infants should be anticipated in breastfed infants. No severe adverse reactions are expected. Amounts in milk can be minimized by avoiding breastfeeding for 3 to 4 hours after a dose.
Drug Levels
Maternal Levels. After intramuscular administration of a single 5 mg/kg dose of dyphylline, peak milk levels usually occurred between 2 and 4 hours after the dose in 20 subjects. Peak milk levels averaged 24.3 mg/L.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Jarboe CH, Cook LN, Malesic I, Fleischaker J. Dyphylline elimination kinetics in lactating women: blood to milk transfer. J Clin Pharmacol. 1981;21:405-10. [PubMed: 7309903]
Substance Identification
Substance Name
Dyphylline
CAS Registry Number
479-18-5
Drug Class
Breast Feeding
Lactation
Anti-Asthmatic Agents
Bronchodilator Agents
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