Drospirenone use while Breastfeeding

Drugs containing Drospirenone: Yaz, Yasmin, Ocella, Gianvi, Beyaz, Loryna, Vestura, Zarah, Syeda, Angeliq, Show all 12 »Safyral, Nikki

Drospirenone Levels and Effects while Breastfeeding

Summary of Use during Lactation

Drospirenone is a progestin that is an analogue of spironolactone. It has antimineralocorticoid and antiandrogenic activities and is available in the US only in combination with ethinyl estradiol as an oral contraceptive agent. Based on the available evidence, expert opinion holds that nonhormonal methods are preferred during breastfeeding and progestin-only contraceptive are preferred over combined oral contraceptives in breastfeeding women, especially during the first 4 weeks postpartum. For further information, consult the record entitled, "Contraceptives, Oral, Combined."

Drug Levels

Maternal Levels. Six women who were between 1 week and 3 months postpartum received a single dose of drospirenone 3 mg plus ethinyl estradiol 30 mcg. Milk was collected for 72 hours after the dose in 2 of the women in whom half-lives in breastmilk were 8.3 and 15.5 hours. The average peak milk level in the 6 women was 13.5 mcg/L at 2.8 hours after the dose. The average drospirenone milk level in the first 24 hours was 3.7 mcg/L (range 1.4 to 7 mcg/L). The authors estimated that a fully breastfed infant would receive a drospirenone dose of about 3 mcg daily.[1] Using the average serum level data, an exclusively breastfed infant would receive 1.1% of the weight-adjusted maternal dosage of drospirenone.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Etonogestrel, Levonorgestrel, Medroxyprogesterone Acetate, Norethindrone

References

1. Blode H, Foidart JM, Heithecker R. Transfer of drospirenone to breast milk after a single oral administration of 3 mg drospirenone + 30 mcg ethinylestradiol to healthy lactating women. Eur J Contracept Reprod Health Care. 2001;6:167-71. PMID: 11763981

Drospirenone Identification

Substance Name

Drospirenone

CAS Registry Number

67392-87-4

Drug Class

Aldosterone Antagonists

Contraceptive Agents, Female

Contraceptives, Oral, Synthetic

Administrative Information

LactMed Record Number

480

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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