Dalteparin use while Breastfeeding

Drugs containing Dalteparin: Fragmin

Dalteparin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because of the low levels of dalteparin in breastmilk and its large molecular weight of 2000 to 9000 daltons, amounts ingested by the infant are small and it would not be expected to be absorbed from breastmilk by the infant. No special precautions are required.

Drug Levels

Maternal Levels. In two women receiving subcutaneous dalteparin 5000 IU daily and 10,000 IU daily, respectively, dalteparin was undetectable in breastmilk.[1]

Anti-Xa activity (a measurement of enoxaparin anticoagulant activity) was measured in the milk of 15 patients before and 3 to 4 hours after 4 to 8 days at a dosage of 2500 IU/day subcutaneously. Anti-Xa activity in milk ranged from less than 5 to 37 IU/L which was 2.5 to 22.4% of the simultaneous maternal plasma anti-Xa activity.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Although not clearly stated, it appears that 15 neonates were breastfed during maternal dalteparin use in one study with no adverse effects reported.[2]

In another study, one mother breastfed her infant for 20 days starting at 7 weeks of age while taking subcutaneous dalteparin 5000 IU subcutaneously twice daily with no adverse effects to her infant.[3]

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Enoxaparin, Lepirudin

References

1. Harenberg J, Leber G, Zimmermann R et al. [Prevention of thromboembolism with low-molecular weight heparin in pregnancy]. Geburtshilfe Frauenheilkd. 1987;47:15-8. PMID: 3569823

2. Richter C, Sitzmann J, Lang P et al. Excretion of low molecular weight heparin in human milk. Br J Clin Pharmacol. 2001;52:708-10. PMID: 11736885

3. Lindhoff-Last E, Willeke A, Thalhammer C et al. Hirudin treatment in a breastfeeding woman. Lancet. 2000;355:467-8. PMID: 10841132

Dalteparin Identification

Substance Name

Dalteparin

Drug Class

Administrative Information

LactMed Record Number

80

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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