Because of the low levels of dalteparin in breastmilk and its large molecular weight of 2000 to 9000 daltons, amounts ingested by the infant are small and it would not be expected to be absorbed from breastmilk by the infant. No special precautions are required.[1]
Drug Levels
Maternal Levels. In two women receiving subcutaneous dalteparin 5000 IU and 10,000 IU daily, respectively, dalteparin was undetectable in breastmilk.[2]
Anti-Xa activity (a measurement of anticoagulant activity) was measured in the milk of 15 patients before and 3 to 4 hours after 4 to 8 days at a daily dosage of 2500 IU subcutaneously. Anti-Xa activity in milk ranged from less than 5 to 37 IU/L which was 2.5 to 22.4% of the simultaneous maternal plasma anti-Xa activity.[3]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Although not clearly stated, it appears that 15 neonates were breastfed during maternal dalteparin use in one study with no adverse effects reported.[3]
In another report, one mother breastfed her infant for 20 days starting at 7 weeks of age while taking subcutaneous dalteparin 5000 IU subcutaneously twice daily with no adverse effects to her infant.[4]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Bates SM, Rajasekhar A, Middeldorp S, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: Venous thromboembolism in the context of pregnancy. Blood Adv. 2018;2:3317–59. [PMC free article: PMC6258928] [PubMed: 30482767]
2.
Harenberg J, Leber G, Zimmermann R, et al. Geburtshilfe Frauenheilkd. 1987;47:15–8. [Prevention of thromboembolism with low-molecular weight heparin in pregnancy] [PubMed: 3569823]
3.
Richter C, Sitzmann J, Lang P, et al. Excretion of low molecular weight heparin in human milk. Br J Clin Pharmacol. 2001;52:708–10. [PMC free article: PMC2014571] [PubMed: 11736885]
4.
Lindhoff-Last E, Willeke A, Thalhammer C, et al. Hirudin treatment in a breastfeeding woman. Lancet. 2000;355:467–8. [PubMed: 10841132]
Substance Identification
Substance Name
Dalteparin
Drug Class
Breast Feeding
Lactation
Anticoagulants
Low Molecular Weight Heparin
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