Medication Guide App

Benzalkonium Chloride use while Breastfeeding

Drugs containing Benzalkonium Chloride: Zephiran Chloride, CureChrome, Tanac, Dr Scholl's Cracked Heel Relief, Herpetrol, Neosporin Neo To Go!, A + D Cracked Skin Relief, First Aid Antiseptic, Benza, Pedi-Pro (Benzalkonium), Show all 11 »Mercuroclear

Benzalkonium Chloride Levels and Effects while Breastfeeding

Summary of Use during Lactation

Topical maternal application of benzalkonium chloride or benzethonium chloride or their presence as a preservative in pharmaceuticals would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Johnson W Jr. Final report on the safety assessment of benzalkonium chloride. J Am Coll Toxicol. 1989;8:589-625.

Effects in Breastfed Infants

A study in Japan randomized 80 consecutive term patients into 4 groups who received either povidone-iodine or benzethonium chloride as a skin disinfectant before delivery and one of these for postpartum vaginal lacerations. Prepartum doses were about 7 mL and postpartum doses were about 0.5 mL of solution. Infant thyrotropin levels were elevated in the infants whose mothers received topical povidone-iodine pre- and postpartum compared to infants whose mothers received benzethonium chloride.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Chlorhexidine

References

1. Johnson W Jr. Final report on the safety assessment of benzalkonium chloride. J Am Coll Toxicol. 1989;8:589-625.

2. Koga Y, Sano H, Kikukawa Y et al. Affect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period. J Obstet Gynaecol. 1995;21:581-5. PMID: 8640469

Benzalkonium Chloride Identification

Substance Name

Benzalkonium Chloride

CAS Registry Number

8001-54-5

Drug Class

Antiinfective Agents, Local

Antibacterial Agents

Detergents

Preservatives, Pharmaceutical

Administrative Information

LactMed Record Number

511

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide
(web3)