Benzalkonium Chloride use while Breastfeeding

Drugs containing Benzalkonium Chloride: Mercuroclear, Zephiran Chloride, Benza, Herpetrol, Dr Scholl's Cracked Heel Relief, Neosporin Neo To Go!, A + D Cracked Skin Relief, First Aid Antiseptic, Pedi-Pro (Benzalkonium), Tanac, Show all 11 »CureChrome

Benzalkonium Chloride Levels and Effects while Breastfeeding

Summary of Use during Lactation

Topical maternal application of benzalkonium chloride or benzethonium chloride or their presence as a preservative in pharmaceuticals would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Maternal Levels. A study randomized 80 consecutive term patients into 4 groups who received either benzethonium chloride or povidone-iodine as a skin disinfectant before delivery and one of these for postpartum vaginal lacerations. Prepartum doses were about 7 mL and postpartum doses were about 0.5 mL. The calculated amount of iodine ingested by the infants in breastmilk during the first 5 days of life correlated well with the amount of povidone-iodine applied to their mothers' skin. Patients who received prepartum povidone-iodine had higher median breastmilk iodide levels on day 5 postpartum than those who received benzethonium chloride (0.93 mg/L pre- and postpartum povidone iodine, 0.64 mg/L benzethonium chloride). [1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A study in Japan randomized 80 consecutive term patients into 4 groups who received either povidone-iodine or benzethonium chloride as a skin disinfectant before delivery and one of these for postpartum vaginal lacerations. Prepartum doses were about 7 mL and postpartum doses were about 0.5 mL of solution. Infant thyrotropin levels were elevated in the infants whose mothers received topical povidone-iodine pre- and postpartum compared to infants whose mothers received benzethonium chloride.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Chlorhexidine, Povidone-Iodine

References

1. Koga Y, Sano H, Kikukawa Y et al. Affect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period. J Obstet Gynaecol. 1995;21:581-5. PMID: 8640469

Benzalkonium Chloride Identification

Substance Name

Benzalkonium Chloride

CAS Registry Number

8001-54-5

Drug Class

Antiinfective Agents, Local

Antibacterial Agents

Detergents

Preservatives, Pharmaceutical

Administrative Information

LactMed Record Number

511

Last Revision Date

20130907

Disclaimer

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