Artemether and Lumefantrine use while Breastfeeding

Artemether and Lumefantrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of artemether and lumefantrine during breastfeeding. However, a dosage has been established for infants weighing as little as 5 kg,[1] so it is unlikely to adversely affect breastfed infants weighing 5 kg or more.

In general, very small amounts of antimalarial drugs are excreted in the breastmilk of lactating women. Because the quantity of antimalarial drugs transferred in breastmilk is insufficient to provide adequate protection against malaria, infants who require chemoprophylaxis must receive the recommended dosages of antimalarial drugs.[1] Tablets can be crushed and administered in breastmilk to enhance absorption in small infants.[2]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Arguin PM, Tan KR. Chapter 3. Infections diseases related to travel. Malaria. In, Centers for Disease Control and Prevention. CDC Health Information for International Travel 2014. New York: Oxford University Press. 2014. http://wwwnc.cdc.gov/travel/yellowbook/2014/chapter-3-infectious-diseases-related-to-travel/malaria

2. Adjei GO, Goka BQ, Binka F, Kurtzhals JA. Artemether-lumefantrine: an oral antimalarial for uncomplicated malaria in children. Expert Rev Anti Infect Ther. 2009;7:669-81. PMID: 19681693

Artemether and Lumefantrine Identification

Substance Name

Artemether and Lumefantrine

CAS Registry Number

141204-94-6

Drug Class

Anti-Infective Agents

Antimalarials

Administrative Information

LactMed Record Number

788

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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