Drug Interactions between clonazepam and Selzentry
This report displays the potential drug interactions for the following 2 drugs:
- clonazepam
- Selzentry (maraviroc)
Interactions between your drugs
No interactions were found between clonazepam and Selzentry. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
clonazepam
A total of 521 drugs are known to interact with clonazepam.
- Clonazepam is in the following drug classes: benzodiazepine anticonvulsants, benzodiazepines.
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Clonazepam is used to treat the following conditions:
- Anxiety (off-label)
- Benzodiazepine Withdrawal (off-label)
- Bipolar Disorder (off-label)
- Borderline Personality Disorder (off-label)
- Burning Mouth Syndrome (off-label)
- Chronic Myofascial Pain (off-label)
- Cluster-Tic Syndrome (off-label)
- Epilepsy
- Hyperekplexia (off-label)
- Insomnia (off-label)
- Lennox-Gastaut Syndrome
- Meniere's Disease
- Migraine Prevention (off-label)
- Night Terrors (off-label)
- Obsessive Compulsive Disorder (off-label)
- Panic Disorder
- Periodic Limb Movement Disorder (off-label)
- Primary Orthostatic Tremor (off-label)
- Restless Legs Syndrome (off-label)
- Seizure Prevention
- Seizures
- Sleep Paralysis (off-label)
- Temporomandibular Joint Disorder (off-label)
Selzentry
A total of 350 drugs are known to interact with Selzentry.
- Selzentry is in the drug class chemokine receptor antagonist.
- Selzentry is used to treat HIV Infection.
Drug and food interactions
clonazePAM food
Applies to: clonazepam
GENERALLY AVOID: Acute ethanol ingestion may potentiate the CNS effects of many benzodiazepines. Tolerance may develop with chronic ethanol use. The mechanism may be decreased clearance of the benzodiazepines because of CYP450 hepatic enzyme inhibition. Also, it has been suggested that the cognitive deficits induced by benzodiazepines may be increased in patients who chronically consume large amounts of alcohol.
MANAGEMENT: Patients should be advised to avoid alcohol during benzodiazepine therapy.
References
- MacLeod SM, Giles HG, Patzalek G, Thiessen JJ, Sellers EM (1977) "Diazepam actions and plasma concentrations following ethanol ingestion." Eur J Clin Pharmacol, 11, p. 345-9
- Whiting B, Lawrence JR, Skellern GG, Meier J (1979) "Effect of acute alcohol intoxication on the metabolism and plasma kinetics of chlordiazepoxide." Br J Clin Pharmacol, 7, p. 95-100
- Divoll M, Greenblatt DJ, Lacasse Y, Shader RI (1981) "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl), 73, p. 381-3
- Juhl RP, Van Thiel DH, Dittert LW, Smith RB (1984) "Alprazolam pharmacokinetics in alcoholic liver disease." J Clin Pharmacol, 24, p. 113-9
- Ochs HR, Greenblatt DJ, Arendt RM, Hubbel W, Shader RI (1984) "Pharmacokinetic noninteraction of triazolam and ethanol." J Clin Psychopharmacol, 4, p. 106-7
- Staak M, Raff G, Nusser W (1979) "Pharmacopsychological investigations concerning the combined effects of dipotassium clorazepate and ethanol." Int J Clin Pharmacol Biopharm, 17, p. 205-12
- Nichols JM, Martin F, Kirkby KC (1993) "A comparison of the effect of lorazepam on memory in heavy and low social drinkers." Psychopharmacology (Berl), 112, p. 475-82
maraviroc food
Applies to: Selzentry (maraviroc)
Administration with food may reduce the bioavailability of maraviroc. According to the product labeling, coadministration of a 300 mg dose of maraviroc with a high-fat breakfast reduced maraviroc peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% in healthy volunteers. However, no food restrictions were used in the clinical studies that demonstrated the safety and efficacy of maraviroc. Therefore, maraviroc can be taken with or without food at the recommended dosage.
References
- (2007) "Product Information. Selzentry (maraviroc)." Pfizer U.S. Pharmaceuticals Group
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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