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Ticar Side Effects

Generic name: ticarcillin

Note: This document contains side effect information about ticarcillin. Some dosage forms listed on this page may not apply to the brand name Ticar.

Applies to ticarcillin: injectable powder for injection.

Warning

Do not use this medication if you are allergic to ticarcillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using ticarcillin tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, a history of any type of allergy, or if you are on a salt-restricted diet.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ticarcillin will not treat a viral infection such as the common cold or flu.

Ticarcillin can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin.

Get emergency medical help if you have any of these signs of an allergic reaction while taking ticarcillin (the active ingredient contained in Ticar) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

Less serious side effects may be more likely to occur, such as:

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to ticarcillin: injectable powder for injection.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, and pseudomembranous colitis.[Ref]

Local

Local side effects have included injection site pain and induration. Vein irritation and phlebitis may occur when undiluted ticarcillin (the active ingredient contained in Ticar) is injected directly.[Ref]

Hypersensitivity

Hypersensitivity reactions have included skin rashes, pruritus, urticaria, drug fever, and anaphylaxis.[Ref]

Metabolic

Metabolic abnormalities have included hypernatremia and hypokalemia.[Ref]

Some studies show a positive correlation between the degree of hypokalemia, the dose of ticarcillin, and the serum BUN/creatinine ratio, suggesting dehydration and higher doses are risk factors for the development of ticarcillin-associated hypokalemia.[Ref]

Hematologic

Hematologic side effects have included anemia, thrombocytopenia, leukopenia, neutropenia, and eosinophilia.[Ref]

Hepatic

Hepatic side effects have included elevations of SGOT and SGPT.[Ref]

Nervous system

Nervous system side effects may include convulsion or neuromuscular excitability with high doses.[Ref]

References

1. Link AS, Jr (1985) "Efficacy and safety of ticarcillin plus clavulanic acid and piperacillin in patients with lower respiratory tract infections." Am J Med, 79, p. 86-7

2. Shenep JL, Hughes WT, Roberson PK, et al. (1988) "Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer." N Engl J Med, 319, p. 1053-8

3. Sanders CV, Marier RL, Aldridge KE, Derks FW, Martin DH (1985) "Safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of community-acquired acute pyelonephritis in adult women." Am J Med, 79, p. 96-100

4. Croydon EA, Hermoso C (1986) "An evaluation of the safety and tolerance to timentin." J Antimicrob Chemother, 17, p. 233-40

5. (2001) "Product Information. Ticar (ticarcillin)." SmithKline Beecham

6. Brown LA, Goldberg ND, Shearer WT (1982) "Long-term ticarcillin desensitization by the continuous oral administration of penicillin." J Allergy Clin Immunol, 69, p. 51-4

7. Welter J, Wittman DH, Freitag V (1981) "Ticarcillin therapy of risk patients with infections due to pseudomonas aeruginosa." J Int Med Res, 9, p. 44-51

8. Finch RA (1981) "Hypernatremia during lithium and ticarcillin therapy." South Med J, 74, p. 376-7

9. Ramirez-Ronda CH, Gutierrez J, Bermudez RH (1982) "Comparative effectiveness, safety and tolerance of mezlocillin and ticarcillin: a prospective randomized trial." J Antimicrob Chemother, 9, p. 125-9

10. Nanji AA, Lindsay J (1982) "Ticarcillin associated hypokalemia." Clin Biochem, 15, p. 118-9

11. Mostow SR, O'Brien RF (1985) "Safety and effectiveness of ticarcillin plus clavulanate potassium in treatment of lower respiratory tract infections." Am J Med, 79, p. 78-80

12. Fass RJ, Copelan EA, Brandt JT, Moeschberger ML, Ashton JJ (1987) "Platelet-mediated bleeding caused by broad-spectrum penicillins." J Infect Dis, 155, p. 1242-8

13. Stuart JJ (1980) "Ticarcillin-induced hemorrhage in a patient with thrombocytosis." South Med J, 73, p. 1084-5

14. Gastineau D, Spector R, Philips D (1981) "Severe neutropenia associated with ticarcillin therapy." Ann Intern Med, 94, p. 711-2

15. Singh N, Yu VL, Mieles LA, Wagener MM (1993) "Beta-lactam antibiotic-induced leukopenia in severe hepatic dysfunction: risk factors and implications for dosing in patients with liver disease." Am J Med, 94, p. 251-6

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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