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Pyridoxine Pregnancy and Breastfeeding Warnings

Brand names: Aminoxin, Nestrex, Vitamin B6, Vitelle Nestrex

Medically reviewed by Drugs.com. Last updated on Apr 25, 2024.

Pyridoxine Pregnancy Warnings

The manufacturer makes no recommendation regarding use during pregnancy.

AU TGA pregnancy category: Exempt
US FDA pregnancy category: A

Comments:
-Pyridoxine requirements appear increased during pregnancy.
-Pyridoxine sometimes helps with nausea and vomiting from pregnancy.

Animal studies have not been performed. There are no controlled data in human pregnancy. Vitamin B6 deficiency is a common problem in pregnant women is common in those not on supplementation.

AU Exempt: Medications exempted from pregnancy classification are not absolutely safe for use in pregnancy in all circumstances. Some exempted medicines, for example the complementary medicine, St John's Wort, may interact with other medicines and induce unexpected adverse effects in the mother and/or fetus.

US FDA pregnancy category A: Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

See references

Pyridoxine Breastfeeding Warnings

Caution is recommended.

Excreted into human milk: Yes

Comments:
-Pyridoxine needs are increased during lactation.
-Concentrations in breast milk are directly proportional to dietary intake.
-Very large pyridoxine doses are reported to inhibit lactation; doses closer to physiologic levels had no effect on lactation.

See references

See also

References for pregnancy information

  1. TGA. Therapeutic Goods Administration. Australian Drug Evaluation Committee (2010) Prescribing medicines in pregnancy: an Australian categorisation of risk of drug use in pregnancy. http://www.tga.gov.au/docs/html/medpreg.htm
  2. Briggs GG, Freeman RK. (2015) "Drugs in Pregnancy and Lactation." Philadelphia, PA: Wolters Kluwer Health
  3. National Academy Press (2018) Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline / a report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. https://www.nal.usda.gov/sit
  4. (2018) "Product Information. Pyridoxine Hydrochloride (pyridoxine)." APP (Abraxis Pharmaceutical Products)

References for breastfeeding information

  1. Briggs GG, Freeman RK. (2015) "Drugs in Pregnancy and Lactation." Philadelphia, PA: Wolters Kluwer Health
  2. National Academy Press (2018) Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline / a report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. https://www.nal.usda.gov/sit
  3. (2018) "Product Information. Pyridoxine Hydrochloride (pyridoxine)." APP (Abraxis Pharmaceutical Products)

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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