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Repaglinide Dosage

Medically reviewed by Drugs.com. Last updated on May 13, 2024.

Applies to the following strengths: 0.5 mg; 1 mg; 2 mg

Usual Adult Dose for Diabetes Type 2

Individualize therapy:
Dose preprandially 2, 3, or 4 times a day

Initial dose: 0.5 mg orally with each meal
Initial dose: 1 or 2 mg orally with each meal

Dose Adjustments: Based upon blood glucose response, double the preprandial dose up to a maximum meal time dose of 4 mg until satisfactory glycemic response is achieved; allow at least 1 week to assess response after each dose adjustment.
Recommended Dose Range: 0.5 to 4 mg orally with each meal
Maximum Daily Dose: 16 mg per day

Comments:

Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Renal Dose Adjustments

Use with caution; allow longer intervals between dose adjustments to fully assess response.

Liver Dose Adjustments

Use with caution; allow longer intervals between dose adjustments to fully assess response.

Dose Adjustments

Debilitated or malnourished patients: Initial and maintenance dose should be conservative with careful dose titration

Patients switching from other oral hypoglycemic agents:


Combination Therapy:

Hypoglycemia:

Dose adjustments may be necessary with concomitant use of CYP450 2C8 and CYP450 3A4 inhibitors and inducers.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.