Clotrimazole Dosage

Medically reviewed by Drugs.com. Last updated on Aug 10, 2023.

Usual Adult Dose for Oral Thrush

Treatment: 10 mg orally 5 times a day for 14 days

Prophylaxis: 10 mg orally 3 times a day for the duration of chemotherapy OR until steroids are reduced to maintenance levels

Comment:

• Safety and efficacy of treatment doses given for a prolonged duration have not been established. Treatment should be limited to short-term use when possible.

Uses:

• Local treatment of oropharyngeal candidiasis that has been confirmed by a KOH smear of other culture before treatment.
• Prophylaxis to reduce the incidence of oropharyngeal candidiasis in patients who are immunocompromised (e.g., chemotherapy, radiotherapy, steroid therapy in the treatment of leukemia, solid tumors, or renal transplantation)

Usual Pediatric Dose for Oral Thrush

3 years and older:
Treatment: 10 mg orally 5 times a day for 14 days

Prophylaxis: 10 mg orally 3 times a day for the duration of chemotherapy OR until steroids are reduced to maintenance levels

Comment:

• Safety and efficacy of treatment doses given for a prolonged duration have not been established. Treatment should be limited to short-term use when possible.

Uses:

• Local treatment of oropharyngeal candidiasis that has been confirmed by a KOH smear of other culture before treatment.
• Prophylaxis to reduce the incidence of oropharyngeal candidiasis in patients who are immunocompromised (e.g., chemotherapy, radiotherapy, steroid therapy in the treatment of leukemia, solid tumors, or renal transplantation)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 3 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Troches must be allowed to slowly dissolve in the mouth for maximal effect.

Storage requirements:

• Store at room temperature; avoid freezing.

General:

• Limitation of use: This drug should not be used to treat systemic mycoses, including systemic candidiasis.
• Safety and efficacy have not been established for prophylactic use in patients who are immunocompromised by etiologies other than chemo-, radio-, or steroid therapy in the treatment of leukemia, solid tumors, or renal transplantation.

Monitoring:

• Periodic hepatic function, especially in patients with preexisting hepatic dysfunction

Patient advice:

• Patients should be instructed to allow the troche to slowly dissolve in the mouth.

Frequently asked questions

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer