Calcium Carbonate / Simethicone Dosage

Applies to the following strengths: 500 mg-125 mg; 1000 mg-60 mg; 250 mg-62.5 mg; 400 mg-24 mg; 750 mg-80 mg; 750 mg-250 mg; 1177 mg-80 mg; 500 mg-20 mg/5 mL; 400 mg-40 mg; 400 mg-40 mg/5 mL

Usual Adult Dose for Dyspepsia

Calcium carbonate 750 mg-simethicone 80 mg: 1 to 2 tablets orally up to 6 times a day as needed or as directed

Maximum dose: Calcium carbonate 4500 mg-simethicone 480 mg (6 tablets)/day
Duration of therapy: Up to 2 weeks

Calcium carbonate 1000 mg-simethicone 60 mg: 1 to 2 tablets orally up to 8 times a day as needed or as directed

Maximum dose: Calcium carbonate 8000 mg-simethicone 480 mg (8 tablets)/day
Duration of therapy: Up to 2 weeks

Comment: Patients should not use the maximum daily dose for longer than 2 weeks unless otherwise directed.

Uses:

Relief of acid indigestion, heartburn, sour stomach, or upset stomach associated with these symptoms
Relief of gas associated with acid indigestion, heartburn, or sour stomach
Relief of bloating and pressure (gas)

Usual Adult Dose for Flatulence

Calcium carbonate 750 mg-simethicone 80 mg: 1 to 2 tablets orally up to 6 times a day as needed or as directed

Maximum dose: Calcium carbonate 4500 mg-simethicone 480 mg (6 tablets)/day
Duration of therapy: Up to 2 weeks

Calcium carbonate 1000 mg-simethicone 60 mg: 1 to 2 tablets orally up to 8 times a day as needed or as directed

Maximum dose: Calcium carbonate 8000 mg-simethicone 480 mg (8 tablets)/day
Duration of therapy: Up to 2 weeks

Comment: Patients should not use the maximum daily dose for longer than 2 weeks unless otherwise directed.

Uses:

Relief of acid indigestion, heartburn, sour stomach, or upset stomach associated with these symptoms
Relief of gas associated with acid indigestion, heartburn, or sour stomach
Relief of bloating and pressure (gas)

Usual Pediatric Dose for Dyspepsia

Weight-based dosing:
Less than 10.9 kg: Data not available

10.9 to 21.4 kg:
Calcium carbonate 400 mg-simethicone 40 mg: 1 tablet orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 1200 mg-simethicone 120 mg (3 tablets)
Duration of therapy: 2 weeks

21.8 to 43.2 kg:
Calcium carbonate 400 mg-simethicone 40 mg: 2 tablets orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 2400 mg-simethicone 240 mg
Duration of therapy: 2 weeks

Age-based dosing:
Younger than 2 years: Data not available

2 to 5 years:
Calcium carbonate 400 mg-simethicone 40 mg: 1 tablet orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 1200 mg-simethicone 120 mg (3 tablets)
Duration of therapy: 2 weeks

6 to 11 years:
Calcium carbonate 400 mg-simethicone 40 mg: 2 tablets orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 2400 mg-simethicone 240 mg (6 tablets)
Duration of therapy: 2 weeks

12 years and older:
Calcium carbonate 750 mg-simethicone 80 mg: 1 to 2 tablets orally up to 6 times a day as needed or as directed

Maximum dose: Calcium carbonate 4500 mg-simethicone 480 mg (6 tablets)/day
Duration of therapy: Up to 2 weeks

Calcium carbonate 1000 mg-simethicone 60 mg: 1 to 2 tablets orally up to 8 times a day as needed or as directed

Maximum dose: Calcium carbonate 8000 mg-simethicone 480 mg (8 tablets)/day
Duration of therapy: Up to 2 weeks

Comment: Patients should not use the maximum daily dose for longer than 2 weeks unless otherwise directed.

Uses:

Relief of acid indigestion, heartburn, sour stomach, or upset stomach associated with these symptoms
Relief of gas associated with acid indigestion, heartburn, or sour stomach
Relief of bloating and pressure (gas)
Relief of overindulgence in food and drink

Usual Pediatric Dose for Flatulence

Weight-based dosing:
Less than 10.9 kg: Data not available

10.9 to 21.4 kg:
Calcium carbonate 400 mg-simethicone 40 mg: 1 tablet orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 1200 mg-simethicone 120 mg (3 tablets)
Duration of therapy: 2 weeks

21.8 to 43.2 kg:
Calcium carbonate 400 mg-simethicone 40 mg: 2 tablets orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 2400 mg-simethicone 240 mg
Duration of therapy: 2 weeks

Age-based dosing:
Younger than 2 years: Data not available

2 to 5 years:
Calcium carbonate 400 mg-simethicone 40 mg: 1 tablet orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 1200 mg-simethicone 120 mg (3 tablets)
Duration of therapy: 2 weeks

6 to 11 years:
Calcium carbonate 400 mg-simethicone 40 mg: 2 tablets orally up to 3 times a day as needed or as directed

Maximum dose: Calcium carbonate 2400 mg-simethicone 240 mg (6 tablets)
Duration of therapy: 2 weeks

12 years and older:
Calcium carbonate 750 mg-simethicone 80 mg: 1 to 2 tablets orally up to 6 times a day as needed or as directed

Maximum dose: Calcium carbonate 4500 mg-simethicone 480 mg (6 tablets)/day
Duration of therapy: Up to 2 weeks

Calcium carbonate 1000 mg-simethicone 60 mg: 1 to 2 tablets orally up to 8 times a day as needed or as directed

Maximum dose: Calcium carbonate 8000 mg-simethicone 480 mg (8 tablets)/day
Duration of therapy: Up to 2 weeks

Comment: Patients should not use the maximum daily dose for longer than 2 weeks unless otherwise directed.

Uses:

Relief of acid indigestion, heartburn, sour stomach, or upset stomach associated with these symptoms
Relief of gas associated with acid indigestion, heartburn, or sour stomach
Relief of bloating and pressure (gas)
Relief of overindulgence in food and drink

Renal Dose Adjustments

Data not available

Patients with kidney stones: Consult with a health care provider prior to using the calcium carbonate 1000 mg-simethicone 60 mg tablet formulation.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None.

Safety and efficacy in calcium carbonate 400 mg-simethicone 40 mg have not been established in patients younger than 2 years or less than 10.9 kg.
Safety and efficacy in calcium carbonate 750 mg-simethicone 80 mg and calcium carbonate 1000 mg-simethicone 60 mg tablet formulations have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

Protect from moisture.
Patients should avoid freezing chewable tablets.

Patient advice:

Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
Patients should be instructed to avoid using products if the tamper evident feature(s) are torn, broken, and/or missing.