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Sertraline for Depression User Reviews (Page 5)

Brand names: Zoloft

Sertraline has an average rating of 6.9 out of 10 from a total of 1183 reviews for the treatment of Depression. 58% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Sertraline

  • Lou
  • September 5, 2016

Zoloft (sertraline) "I've been on the generic sertraline 50mg for about two weeks, and I feel so much better. I was very depressed, irritable, had insomnia, and felt like a total failure at life. I had a little diarrhea at first, but then I also have IBS so I wasn't surprised. After a few days, that stopped. I feel like my old self again, like a weight has been lifted from my shoulders. I'm even singing again, I haven't done that in about a year. I was in denial for a long time, I told myself I could handle the depression - I was wrong. This is the first antidepressant I've been on, and I am very pleased with how much it has helped me."

9 / 10
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  • Trusso
  • July 18, 2015

Zoloft (sertraline) "I was diagnosed with Generalized Anxiety Disorder, severe depression, and OCD when I was around 18 years old. I couldn't do anything and shut down. I went to a mental hospital to take classes on how to cope, and I began trying different types of SSRIs. I tried two others, and I felt horrible on them both. Then I tried Zoloft. My mom made me stick with it even though I was skeptical. I started with 25, 50, then to 75 mg. Nothing helped. As soon as I went up to 100 mg is when I felt my life coming back. I could feel emotions of happiness and felt like life finally had a meaning to it. I was able to be okay again and felt like this medicine saved my life. The thing that is hardest is all the people judging, saying 'you're on so many Meds'."

10 / 10
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  • colle...
  • Taken for less than 1 month
  • February 2, 2016

Zoloft (sertraline) "My depression began slowly at first, then all at once I couldn't bear myself anymore. I am a sophomore in college (female). In the evenings and going on into the night, my mood dropped so fast and I would get so sad over nothing. After talking to a counselor, and making the tough choice to medicate, she put me on a starting dose of 50 MG Zoloft. After taking the first pill, I was doing some research and had myself so freaked out that night that the side effects would be awful. I was so worried I would have to skip work or class. I have been on the medication a few weeks now and I had zero problems! I could not be more impressed. My moods are already stabilizing and I feel so much better already! Good luck to anyone starting!!"

8 / 10
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Frequently asked questions

  • Happy...
  • February 7, 2017

Zoloft (sertraline) "It's so difficult looking at reviews because so many are negative. I have moderate depression and generalized anxiety disorder. I started taking antidepressants pretty young, maybe 6th or 7th grade. I took Lexapro, Prozac, and something else before I got on Zoloft. I just recently got off Zoloft to see how I'd do without it, and so far I've been okay. Anyways, Zoloft was practically a lifesaver for me. I'm not sure if I have experienced any of the side effects, but if I have, they obviously didn't make much of a difference. This review is here to say don't be scared to take Zoloft; it might be the perfect drug for you!"

10 / 10
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  • Bucky...
  • Taken for 10 years or more
  • January 3, 2014

Zoloft (sertraline) "I have to say that Zoloft saved my life. I have been on it for over 10 years, but about a year and a half ago, I switched to another pill just to try it. WHY I don't know, I should have never left Zoloft. I then started to take a muscle relaxer for a sore shoulder. BE VERY CAREFUL in taking other medications with any antidepressants. The dread, the worthlessness, the crying all came back. Back on Zoloft for about a week and I can function once again. THANK YOU ZOLOFT."

10 / 10
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Are you taking this medicine?

  • Santa...
  • Taken for 1 to 6 months
  • March 23, 2024

Zoloft (sertraline) "Zoloft is a life saver! I recently left my ex-husband, and I was going through some weird, scary emotions. I would be very anxious at times. My psychiatrist put me on Zoloft, 25 mg, and it took the scary, anxious feeling away. I'm not that heartbroken anymore. The only side effect I'm having is bad heartburn. I'm on 50 mg now, and I feel great."

10 / 10
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  • Ellie
  • Taken for 2 to 5 years
  • February 23, 2020

Zoloft (sertraline) "I am glad to find a place that I can tell my story & maybe get some opinions. I started taking Zoloft when my husband of 53 years passed, that was 3 years ago. I had the doctor give me instructions on weaning from it in November. So now it has been 8 days off. I did not have any side effects until today. After I got home from church I just broke out in tears & I am not a crier. Is it normal to get this effect after 8 days off? I really would like to stay off the med. Thanks"

7 / 10
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80 Report

More FAQ

  • MayraP
  • December 30, 2016

Zoloft (sertraline) "Long story short, I finally felt compelled to try antidepressants. I had experienced depression for a couple of years and had bouts of anxiety. The last straw was symptoms similar to bipolar disorder, like mania. I had been so reluctant to try meds, but man, I'm glad I did. I'm sad I didn't try them before. My life these couple years would have been so much better, less traumatic. I started 50 mg of sertraline in July. Right away, I noticed my mood improved. I used to be short-tempered, now I am more patient. I stopped crying every two days out of frustration due to my son's tantrums or misbehavior (challenging toddler) or from feeling overwhelmed with housework. Little by little, that fog of depression started to dissipate. I am happy now."

10 / 10
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  • BAano
  • May 22, 2015

Zoloft (sertraline) "Absolutely changed my life. I am a 20-year-old female who has struggled with depression and irritability since roughly 13. I tried meditation, I tried the 'power of positive thinking', I tried listening to podcasts, I tried counseling. Nothing helped me until Zoloft. I've been taking Zoloft for 5 weeks. I had minor side effects for the first couple of days (looser stool, headaches, stomach aches) but nothing I couldn't handle, and they went away after 2-3 days as I got used to the medication. I'm currently taking 50 mg and don't plan on increasing. I feel overall happier. I'm not as irritable, and things that I used to hate (going to work) are no longer even bad. I feel more myself, and like I'm not afraid to be outgoing. Highly recommended."

10 / 10
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  • Nattie
  • Taken for 1 to 6 months
  • October 3, 2020

"I have taken sertraline 3 times in my life. First time in 96 after a very big depression 25 years ago. This drug saved my life from suicidal thoughts. When I first took it I had a lot of nausea. The second time I took it was 4 years later after an other major depression and again it saved my life and I became gradually better and better, but this time I didn't the nausea. After this I used sertraline again, an other couple of times to actually prevent major depressions when I felt extremely unhappy or after a tragedy. Sertraline saved my life. Thanks a million for everybody involved in the research of this drug ."

10 / 10
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  • mickey
  • December 11, 2013

Zoloft (sertraline) "Before I started taking Zoloft for depression and anxiety, I was also suffering from insomnia. I was taking Ambien and Valium to help, but the Ambien was not really helping my insomnia. Maybe I got 3 hours of sleep or 5 hours on a good night. I suffered from panic and anxiety attacks. I went to therapy, and after some time, the doctor recommended Zoloft. I was hesitant at first, but I could not live like this anymore, so I started taking it about a year ago. Zoloft is the best thing I could have done. The first week or two I had side effects, but soon after, the depression lifted and anxiety was gone. I sleep great now."

8 / 10
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  • Perry...
  • July 15, 2009

Zoloft (sertraline) "From the first week when I took this medicine, I can feel a slight change and haven't felt depression or anxiety. But as the weeks pass, I felt much better. I've got my life back, social skills, and feel like everyone else. This drug has really helped to bring my life back."

9 / 10
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  • Wacko
  • October 9, 2018

"My symptoms were anxiety, depression & intrusive/repetitive thoughts. I struggled initially with side effects when starting on 50mg (deepened depression, headaches, dry mouth & insomnia), which I had reduced to 25mg during week 1, which I found helped. Week 2, I raised again to 50mg and the side effects began to wear off. I continued on 50mg until week 4 and showed small signs of improvement (sleeping longer, reduced anxiety and depression), I had good days and bad days! I spoke with my GP, who increased my dosage to 100mg and have been taking for 1 week. I noticed some mild side effects resurfaced initially, but faded after a few days. I am now beginning week 6 and I am beginning to feel fantastic and back to my old self. I have read other posts on here seeking inspiration and positive feedback, so wanted to give something back. If you can get through the early phases and stick with this med 4-6 weeks, and if compatible, the Sun will certainly shine once more."

10 / 10
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  • Seren...
  • Taken for 1 to 6 months
  • December 6, 2014

Zoloft (sertraline) "I took Sertraline for Moderate Depression which it was exceptionally good at diminishing. I have been taking it for just under 6 weeks for moderate depression, social anxiety and generalized anxiety. It worked for depression the best, by far; however, not half as good for the anxiety, perhaps because it requires a higher dose and longer intake. Definitely consider Sertraline for depression, its side effects were minimal (if any because it was so unnoticeable)."

10 / 10
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  • Abbeyjd
  • Taken for 1 to 6 months
  • August 16, 2017

Zoloft (sertraline) "I took Zoloft (generic) shortly after my anxiety got horribly severe. I took lexapro a few years ago but didn't like the sexual side effects. Doctor put me on Prozac but that appeared to put me into a deep depression. I had never had depression, just anxiety but I couldn't get out of bed I was just paralyzed. After a few weeks of that I decided to try Zoloft. Within the first three weeks I felt tremendously better. By 6 weeks I felt totally back to normal and NO sexual side effects! This has been my miracle drug"

10 / 10
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  • Lizbee
  • Taken for less than 1 month
  • March 5, 2016

Zoloft (sertraline) "So far, this drug has saved my life. After experiencing a traumatic experience, I spiraled into a heavy depression coupled with anxiety. It's only been one week, and I'm no longer crying daily, and the hopeless feeling is subsiding. It's also helped stop the obsessive thoughts I've been having about the traumatic event."

9 / 10
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  • Summer
  • Taken for less than 1 month
  • March 17, 2019

Zoloft (sertraline) "I have taken a few antidepressants just looking for perfect fit. DO NOT TAKE ZOLOFT my side effects were so severe I have been out of work for 2 weeks. Prozac was probably the best. My experience was so bad that I now take 0 meds because of the ill effects. I can give you pointers on natural remedies."

1 / 10
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  • Sarah
  • Taken for 1 to 6 months
  • September 5, 2018

Zoloft (sertraline) "When my doctor prescribed me Zoloft I was scared of the side effects and put off taking it for a few days. Now I could not be happier that I started taking it though. I have been on 50mg for almost 5 weeks and have not noticed any side effects.... my depression has gotten so much better. I wake up excited about the day and just feel generally happy and nothing feels so difficult anymore. I haven’t cried once since starting the medication whereas beforehand I was crying every day and all I wanted to do was lay in bed. My friends and family as well as myself have all noticed a huge difference in me. I’m so happy with my progress on Zoloft so far. I am hoping that it helps improve my general and social anxiety soon because I have not seen much of an improvement there but I know it can take 8 weeks. Definitely recommend this medication and don’t be scared to start taking it! The side effects are rare and it will be the best decision of your life."

8 / 10
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  • Shann...
  • Taken for less than 1 month
  • September 4, 2016

Zoloft (sertraline) "I have been on 50mg of Zoloft for a little over 3 weeks now. For the first week, I noticed no change, then gradually I was feeling better. It has given me more energy, and I feel I have a more positive attitude. I was overeating a lot due to stress and depression that has completely subsided. Since I started taking it, I have lost 19 pounds. That has also really helped with my depression. I am scared of my body getting used to it and going back to my regular habits. As for now, I am happy."

10 / 10
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111 Report
  • Blaze...
  • October 27, 2009

Zoloft (sertraline) "I was prescribed Zoloft for depression. I had tried Wellbutrin and Lexapro in the past with little results. With Zoloft, at first, the side effects were tough. Also, I was having sexual side effects. Lacking desire (which is not normal for me), and the inability to achieve orgasm. I decided to try taking my pills in the morning, rather than at night like I had been doing. After a couple of days passed with my new schedule, the sexual side effects subsided, and I'm back to normal with that. I never knew an antidepressant could help so much, but it has REALLY helped me!"

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  • Karmic
  • September 20, 2019

"Started taking sertaline around 6 weeks ago after years on crippling fatigue, feeling of complete self-loathing and no desire to engage with the world. I finally accepted that maybe these symptom were all due to depression, which I've been living with for most of my adult life Started on 25mg for a week no side effects and no change, upped to 50mg for two weeks and felt really tired, still no change, then upped to 100mg in week 4 and this is when I noticed the changes. I feel happy, the ruminating thoughts have dissipated, I'm interested in life and myself again and I'm genuinely excited about life. I realise now just how depressed and down I actually was My advice to anyone reading this is not to be perturbed by bad reviews, side effects are bearable and go away when you stop taking the meds so if your doctor has suggested trying Sertraline or any other SSRI my advice is try it, don't suffer unnecessarily like I have for almost 20 years."

10 / 10
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  • jaybee
  • September 1, 2013

Zoloft (sertraline) "I have been taking Zoloft for 8 weeks and the result has been amazing. The beginning was rocky with nausea, heavy head, and fatigue, but it gets better. I am more confident, better at my job, I enjoy socializing far more, my relationship is saved, and I generally feel more balanced. I have had anxiety since childhood and struck depression in late teens; I am now 27. Not sure how long I will or should take Zoloft, but I am hugely relieved."

8 / 10
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  • A...
  • June 27, 2016

"I have been in a major depression for 3 years, and possibly a minor depression before that. I also have anxiety and social phobia. I have been on Sertraline for almost two months now, and I noticed an enormous difference in the first few days. I started to smile, laugh, make eye contact, and the fear of public is slowly easing! I cannot describe how bad life was before Sertraline. I am 34 years old and have been living a life that wasn't a life at all. Now I am feeling better than I have ever felt. I do get dry mouth, but oh, to laugh again! (Worth it). I am usually not a person who even uses Tylenol, so for me to try this, I was desperate. I don't feel high, nor drugged, or even out of my body! I feel whole."

10 / 10
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  • Hope-...
  • Taken for 1 to 6 months
  • October 14, 2015

Zoloft (sertraline) "I've been on Zoloft for 3 months now. Initially, I suffered from side effects such as shivering, loss of appetite, drowsiness, and insomnia. These symptoms lasted for about three days. I was scared at first and planned on trying another medication for anxiety. However, I called my cousin who is a nurse, and she told me to try cutting the pill in half. I took my cousin's advice and cut the pill in half, taking only 25mg a day, which works really well for me. I'm 5'4, 130 lbs. I no longer suffer from anxiety. After taking Zoloft, I realized that I was suffering from depression. Zoloft alleviates my anxiety and has greatly helped with my depression. I now feel happier and more motivated to do things right away without procrastinating. Life-changer!"

10 / 10
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  • Milan
  • April 18, 2014

Zoloft (sertraline) "After years of trying different medications, sertraline has finally been the most useful and compatible one for me. If only I had found this years ago as it has lifted my depression, improved my social skills, and eased my obsessive-compulsive disorder symptoms (would trigger after anxiety)."

9 / 10
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133 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.