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Semaglutide User Reviews & Ratings (Page 2)

Brand names: Ozempic, Wegovy, Rybelsus

Semaglutide has an average rating of 6.6 out of 10 from a total of 1,987 reviews on Drugs.com. 54% of reviewers reported a positive experience, while 25% reported a negative experience.

Reviews for Semaglutide

  • Jarin
  • Taken for 1 to 6 months
  • August 30, 2020

Rybelsus (semaglutide) for Diabetes, Type 2 "This med Rybelsus is awesome. It has helped me bring my A1C down to 5.1 from a high of 9.7. I first started with the 3mg and am now on the 14mg. Been on this med since March and while I did experience some nausea and mild upset stomach, it went away after about a week. It has also helped me lose 50 lbs as well. I also take it with metformin. I should be the poster child for this drug... even though I'm 50."

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  • Sane...
  • March 13, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "After reading this, that junk in the fridge will go in the garbage. Do NOT put yourselves through this for weight loss and even diabetes. I mean seriously, which is worse? Pancreatitis? Thyroid cancer? Horrible gastro conditions? Injecting ourselves with this lizard juice can't be good for us. And, it’s beyond expensive to say the least. Pharmaceutical companies should be ashamed of themselves but that’s nothing new. This is totally off the charts. Just say no to drugs these drugs. Please be fair and unbiased and publish this comment, if you’re fair and unbiased!"

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  • Anon
  • Taken for 1 to 6 months
  • May 19, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "I was terrified to take this after reading some of the reviews online, but I have to say I am so happy I started this drug. I've followed others' suggestions about injecting the drug into my upper thigh and not my abdomen. I was on a 0.25 dose for 4 weeks, then moved to 0.5, and that's what I currently take. My appetite has decreased SIGNIFICANTLY. I was addicted to eating junk foods, and I simply cannot eat them anymore; my stomach cannot handle them. I get full after eating one properly sized meal, and it keeps me going for most of the day, only having a snack like 1 apple in the evening. Side effects were mild for me; I had some constipation, but I started taking fiber supplements to help with that. I have been on the medication for 7 weeks now, and I'm down 10 lbs, and I feel great. Make sure your doctor gets you to increase the dose slowly, inject into your thigh, and be ready to make better dietary choices when starting this drug. I truly believe it saved me from morbid obesity."

10 / 10
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Frequently asked questions

  • Respi...
  • Taken for less than 1 month
  • February 9, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "This medication has been amazingly good. Wow! It's only been 4 days, but my thought process of always thinking about what I am going to have for my next meal, always food shopping, always having cravings to eat, never feeling full. THAT'S ALL CHANGED! I am eating half of what I did. I am only eating when I am hungry, and that is less frequent. This is not in my head, I know there is a change. Thank you so much. Yes, of course, 4 days is not enough time, but I am hoping that the 12 hours of thinking about food stops. Each and everyone out there knows what I mean. We are constantly thinking about what we will have for our next meal, food shopping, collecting recipes, eating 2 or 3 portions of food, eating between meals, having desserts, etc. Next report will be after a couple of weeks."

10 / 10
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  • Conce...
  • Taken for 1 to 6 months
  • February 1, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "I started Ozempic in late December at 0.25 injection. I also take 500mg metformin per day. Soon after I started Ozempic, I had decreased appetite and my sugars improved, but I had reflux, gas, bloating, nausea, and diarrhea. After 4 weeks, I started 0.50. 2 weeks in, I have bouts of painful constipation then diarrhea, nausea, bloating, gas, reflux, and cramping. I've almost vomited a few times. When I eat, it feels like the food just sits and sits, barely moving through my gut. My doctor wants me to stick with it, saying that these side effects usually improve, but it's been pretty miserable. I'm thinking I'm going to stop taking it. While Ozempic has been effective in regulating my sugars and losing weight, I don't think it's worth the suffering that I've been enduring on this medication. I understand that studies showed it causing thyroid cancer in mice, but no one knows if it causes thyroid cancer in humans. I don't want to be the guinea pig the drug makers use to find out it does."

5 / 10
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Are you taking this medicine?

  • Tracey
  • Taken for 1 to 6 months
  • September 20, 2021

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been on Wegovy for 2 months now, and I'm down 17 lbs. I don’t exercise. The only thing I changed was to stop drinking cokes and try to eat a little better. I have found that certain foods can make me nauseous. The medication pretty much tells me when I'm full, and if I try to push the amount, I get sick to my stomach. This medication works for me."

10 / 10
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  • Saucy
  • December 3, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "Been on Ozempic since mid-April 2020. All side effects listed with the worst being chronic diarrhea. Nausea has been significant but has settled to occasionally. Trying to follow a more plant-based diet, I have lost today an official 60 pounds. I find the less meat I eat, the more energy I have, the better my blood sugars are as well. I am 53, so weight loss isn't impossible for us older ladies..."

7 / 10
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More FAQ

  • jamison
  • Taken for 1 to 6 months
  • June 2, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "I have been on 0.5 Ozempic for 2 months now. The nausea is no better. I vomit almost every day. Driving down the road and I begin to vomit. Almost caused me to wreck my car twice now. I've lost 30 pounds and feel terrible. My stomach hurts all the time and now my back. I do not urinate much at all even though I've increased water. Calling today and going off it. Losing weight is great, but not at the cost of feeling horrible every day."

5 / 10
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  • Anne
  • December 28, 2020

Rybelsus (semaglutide) for Diabetes, Type 2 "I started taking Rybelsus at the beginning of August for weight loss. The biggest con for me is that it causes constipation and then usually diarrhea when I finally do go to the restroom. I have only had issues with nausea when I try to eat past the point of being comfortable. It is also important to try to eat something within an hour of taking the medication. When I first started on the medicine, I could only eat a few bites of food and then would feel extremely full and bloated and would have to stop. Now, it is 4 full months later, and I am on the 14mg, and I can continue to eat beyond a few bites without feeling miserable, but I try to stop as soon as I am full. I have, so far, lost 30 lbs with no exercise and have gone from a size 12/14 to a size 6/8. Diabetes does run in my family, so I am hoping continued use of this drug may help prevent the development of diabetes in the future."

10 / 10
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  • Momo
  • Taken for 1 to 2 years
  • April 30, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "I have been taking Ozempic for 16 months and have lost 80 lbs! I started at 0.25 and have moved up to 1. At first, I was terribly sick, but I took my time to adjust bit by bit while the dose was slowly raised, and now I don't feel sick at all from it. If you can hold on and push through (the push was hard, REALLY sick some days), it does get better. It has saved my life."

10 / 10
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  • Sally
  • Taken for 1 to 2 years
  • March 9, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Wegovy & Ozempic (both are Semaglutide, but Wegovy is a higher dose) have been LIFE-CHANGING. It has turned off the 24/7 hunger switch in my brain. I feel “normal” around food for the first time in my life. I started with Ozempic Jan 2021 and switched to Wegovy Oct 2021 (now at full 2.4 mg dose). To date, I’ve lost 87 lbs! I have 50 lbs more to lose. I’ve had virtually zero side effects, just minor upset tummy the 1st week. I feel full/satisfied with much less food, I no longer think of food constantly, I respond dramatically less to food cues (seeing or smelling food), and I no longer get overwhelmed at restaurants/holidays because of all of the delicious food options. I’m in control. The only bummer is the price. My Wegovy coupon is about to run out and my Ins doesn’t cover it."

10 / 10
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  • Cheryl
  • Taken for less than 1 month
  • January 30, 2022

Ozempic (semaglutide) for Cardiovascular Risk Reduction "I did lots of research before starting Ozempic, so was aware of potential (hideous) side effects. I started a week ago on a starting dose of 0.25. (Had my second 0.25 dose this morning). Super, super, super happy! Based on research, I have opted to inject in my upper leg rather than my tummy. I don’t know if it’s based on the injection location, or if I’m just lucky, but I have had ZERO side effects. No nausea, no dizziness, nothing. I am eating three sensible, small, low-fat meals a day, with perhaps a small amount of fruit as a snack, and walk my dog regularly. I am down 1 kg (2.2 pounds) over the week, and am super confident that I will be able to continue on Ozempic until I get down to my goal weight (20 kg/44 pounds to go). Although my doctor said he will increase my Ozempic to 0.5 then 1mg over the next 2 months, I am going to say no and stay on 0.25 for as long as that works for me. Why increase if the current dose is working! I am 55. Cost in Australia = $132 per script."

10 / 10
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  • Margie
  • September 27, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "I was put on Ozempic after taking Glimepiride for several years. I started on 0.25mg, then onto 1mg. I started having the nastiest burps ever, then diarrhea 3 to 4 times a day. After 3 months, I went to a gastroenterologist and was diagnosed with gastroparesis, a side effect of Ozempic. I have all the side effects - nasty, offensive-smelling burps, eye floaters in both eyes, bad diarrhea, stomach pain, and now this disease that has caused precancerous cells. Yes, my appetite has decreased, I have lost 15 lbs in 3 months, and my numbers are good. But it's not worth being sick every day. I just found out my daughter is going through the same exact thing. So, take it at your own risk."

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  • The...
  • Taken for less than 1 month
  • April 6, 2021

Rybelsus (semaglutide) for Diabetes, Type 2 "It’s been a week on Rybelsus 3mg. I feel pretty good (except for seasonal allergies). No nausea, no vomiting, no diarrhea, smaller appetite. I am prediabetic with BMI >30. I would like to lose 30 to 40 pounds. I think Rybelsus will help me. (Prior to taking Rybelsus, I was fasting (16-hour/8-hour) and exercising EVERY day and STILL gaining weight.) I think Rybelsus will help. I weigh daily, and I am beginning to see the numbers ever so slightly trend down. I am optimistic. I will start 7mg after 30 days. I hope to come back here and share my journey with you."

10 / 10
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  • Will
  • Taken for 1 to 6 months
  • February 7, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "Did the first 4 weeks of Ozempic at 0.25 had mild stomach issues. Nausea was come and go, really not consistent. Helped control my eating. Doctor said if you overeat or eat like you used to, you will throw up. There is no place for overeating but up. Didn't overeat, didn't have much issue. Took stool softener to keep things moving. At the 0.5 dose, ate less but had fewer side effects than my first dose. Glad I have started the med, it works."

10 / 10
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  • JEano
  • Taken for 1 to 6 months
  • August 26, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "I have been taking Ozempic for 4 months to reduce insulin resistance (caused by polycystic ovary syndrome). The medication has significantly reduced my appetite. I have had a few minor side effects - a stomach cramp here, an episode of diarrhea there...but nothing at all significant. My weight went from 151 (BMI 25.9) to 133 three months later (BMI 22.8). I honestly could not be happier."

10 / 10
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  • elish...
  • April 3, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Started on 0.25 mg. Had some side effects but not enough to stop taking it. Nausea, but not terrible, heartburn which was bad at times, Pepto-Bismol sorted it out (have some on hand). Curbed appetite, but noticed it starting to not be so effective when it was time to up the dose. I am now on 0.5 mg. The third week, and I am on a new dose, and there's a big change. I have heartburn most of the time, especially if I try to eat starchy carbs (1 slice of bread). Nausea here and there, but since I took the third dose of 0.5 mg, I have absolutely zero appetite. I know I should eat, but 1 or 2 mouthfuls of food is enough for me. I lost 12 lbs in the first month and will weigh myself at the end of the second month. Conclusion: if you really can't stop eating, and your health is suffering, speak to your doctor about Wegovy. It's not a magic wand, but will definitely help you. Make sure you drink plenty of water throughout the day."

9 / 10
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  • tallg...
  • Taken for 1 to 6 months
  • December 16, 2021

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been on Wegovy since the end of July 2021. With difficulty finding the prescription, I have had to go a few weeks between refills, so I am halfway through my fifth month. I am down 34 pounds since starting and haven't been hungry. It has been the solution to a lifetime of weight struggles! I did have hair loss start in the fourth month and have added a multivitamin to help. My hunger was so low, I asked my doctor to take me back to the month three dosage. Hoping both the vitamin and decreased dose will help with hair loss... so far it isn't noticeable to anyone but me (and my family seeing the hair on the floor/in the shower!). Even if I have had to go 1-2 weeks between doses due to backorder, I find I am still losing weight and my lack of hunger is the same. I occasionally eat 'bad' foods (fast food, desserts) and haven't noticed any bad effects or issues. I just can't eat much of anything, so I try to focus on healthy protein and fats and lots of veggies/salads."

10 / 10
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  • 2Timer...
  • Taken for 1 to 6 months
  • January 18, 2021

Rybelsus (semaglutide) for Diabetes, Type 2 "For 2 years, my diabetes went out of control to the point that I started having some mental issues like brain fog. My doctor put me on 3mg Rybelsus. The first two weeks were a bit of a struggle, nothing I couldn't handle, just nausea and no desire to eat. A month in, my doctor took me up to 7mg. The first week at 7mg was the same, nausea, but after the week ended, it was gone. I still don't have a major appetite, which is excellent. My blood sugar is 104 at this moment. I've lost 24 pounds so far in 6 weeks. I love this stuff. I also feel much better, and I can actually think without the fog. I recommend it."

8 / 10
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  • Mom...
  • Taken for 1 to 6 months
  • December 29, 2021

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Just took my last injection of month 5, 1.7. I have lost about 25-30 lbs along with 3-5 days a week at the gym. Definitely curbs your appetite. The nausea is very real! Each month I thought it would get easier. It never does. A couple times I puked for hours. Lots of belching. In the beginning, a little constipation. The first day or 2 after the injection, you can feel fatigue. It works for weight loss if you can tolerate the nausea. This will be my last month. I have a 6-month prescription but I can’t deal with the nausea anymore."

8 / 10
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  • Maria...
  • Taken for 6 months to 1 year
  • February 1, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "I started taking Ozempic in June 2020, initially lost 20 pounds by August. Total of 30 pounds so far, last 10 have been a lot slower. I went from 186 pounds to 156 pounds. A1c went from 6.5 to 5.6. Minimal side effects include occasional nausea and constipation. Started using Miralax, which has helped. Side effects I have experienced are worth the benefits. I consistently wake up with glucose levels in 80-90 range, never out of the green zone on a glucometer. I cannot overeat. If I do, I feel ill or get heartburn, so I have learned my lesson. I am really happy with this medication."

10 / 10
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  • P-C
  • Taken for 6 months to 1 year
  • March 25, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Wegovy has been the most positive life-changing medication I have ever used! I lost 85 pounds in 6 months. I was lucky to not have side effects, many of my coworkers are now having my positive experience with Wegovy as well. I feel like a role model. A friend said you should be a spokesperson for Wegovy."

10 / 10
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  • Brenlee
  • Taken for 1 to 6 months
  • May 26, 2024

Ozempic (semaglutide) for Diabetes, Type 2 "Started with the 0.25 dose & after 5 weeks went to 0.50. Side effects were minimal, mostly just an upset stomach for the first day after a shot. Pens were easy to use & directions easy to follow. My A1c went from 10.3 to 6.2 after 90 days & I lost 22 lbs. I made significant dietary changes, which were helped because overeating gave me that 'too full to move' feeling you get on Thanksgiving, even with small portions. I eat 4-5 times a day but in small portions & calories under 1200 daily. Constipation was avoided by an increase in fiber/vegetables and water."

10 / 10
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  • Londo...
  • Taken for 1 to 6 months
  • January 8, 2021

Ozempic (semaglutide) for Cardiovascular Risk Reduction "Having struggled with a need for carbs and sugar for over 2 decades, it caught up with. Constantly sluggish, despite regular exercise. Risk of heart issues as I have an inherited Cholesterol disease. Weight, well that's a given, most females postmenopausal struggle to lose weight. So, after all sorts of natural therapies and a ton of exercise, nothing helped very much. My GP mentioned Ozempic, even though I was only pre-diabetic she still felt it would help. After the usual low-dose start - 6 weeks later up to 1mg. I have been injecting weekly and 6 months later, I am not only 30 lbs down, I feel so brilliant. More energy, better sleep, and no sugar cravings at all. It has been great. No side effects, maybe a little constipation at the start (mainly due to a change in eating habits). Superb med, wish more people could be offered the chance to use it. It is still expensive in the insurance world, however, hopefully like many other meds in this country, the costs will lessen."

10 / 10
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  • Mildred
  • Taken for 1 to 6 months
  • December 9, 2021

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I started Wegovy at the end of July 2021. I was up to the second dose amount. I stopped it on October 8, 2021, because I was experiencing extreme hair loss. I had called and spoken to a Wegovy representative the month before about it, and they said someone was going to call me, as this was not a side effect that they knew of. No one ever called. I did look on another site, and it did show hair loss. Knowing that hair loss with this product is real. It has been a very depressing time for me as the way I look at myself has changed because of the loss of my hair. HAIR LOSS IS REAL WITH WEGOVY"

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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.