Skip to main content

Modafinil for Depression User Reviews (Page 3)

Brand names: Provigil

Modafinil has an average rating of 8.8 out of 10 from a total of 70 reviews for the off-label treatment of Depression. 83% of reviewers reported a positive experience, while 6% reported a negative experience.

Reviews for Modafinil

  • M855
  • January 27, 2016

"I think I might be the only person in the world having no beneficial effect on this drug. I took 50 Mg Modalert and I never felt so bad in my life: I was paranoid, anxious, had several serious suicidal thoughs , headache and nausea. I kept feeling bad for the next 24 hours. I feel so disappointed and sad, I was hoping that moda could have helped me"

2 / 10
Was this helpful?YesNo
31 Report
  • Arrow...
  • April 21, 2016

"I was extremely hopeful upon reading the raving reviews about Modafinil for depression , especially for initiative and motivation. I was practically expecting it would work so if anything, I was the perfect candidate for the placebo effect. But it was not to be. I took up to 200mg but found it to have no effects at all on my depression. It actually made me slightly anxious and agitated. Though, it does work very well with making you stay awake and alert. "

3 / 10
Was this helpful?YesNo
29 Report
  • BillZ...
  • Taken for less than 1 month
  • April 23, 2015

"It was a strong drug. It had the side effect of leaving me tired and very depleted the following day far more than small 5mg of ritalin did. The only caveat is I took valium at bedtime. This may have messed with the Provigil to the degree that it may have messed with my system. I think this entry is valuable. Benzodiazepines do not appear to be useful in combination with Provigil or Modafinil. Days when I did not take Benzodiazepines the following days were pretty normal. The important entry I want to contribute is to say that the days following a Provigil day were the ones that were the most productive. I was far more "on" after the drug wore off. I felt like a younger faster version of myself days even a week later. 100mg dose"

5 / 10
Was this helpful?YesNo
29 Report

Frequently asked questions

  • yayjosh
  • Taken for 1 to 2 years
  • November 19, 2022

"I’m diagnosed with Depression and ADHD. After various research, I asked my doctor if I could try modafinil, and he agreed, so I started taking it at the 100mg dose. In the first days, this medicine felt like a miracle. I was extremely energized, focused, motivated, and happy in general. My only side effects were a lack of appetite and insomnia if I took this medicine too late. Unfortunately, this drug builds tolerance really fast, and after just 1 week, all those positive effects disappeared, and the drug didn’t have any effect anymore. I won’t advise taking this drug for long-term usage; however, if you space out your doses and take it 1-2 times a week, the effects will be much stronger and can help you going through the day, so maybe, that’s the most appropriate strategy."

7 / 10
Was this helpful?YesNo
7 Report
  • ephia...
  • Taken for less than 1 month
  • April 24, 2016

"I have been on modafinil since three weeks. Was previously on fluoxetine since a year,self prescribed for apparent depression. I.stopped fluoxetine cold Turkey 3 weeks back and put myself on modafinil. I have carried well since. Tried stopping fluoxetine suddenly previously also without any replacement drug,but got severe mood disturbances,and wasn't successful. Modafinil is helping me for good ever since. But I started having serious side effects since last week.. severe muscle cramps, mainly in calves,backaches,pain in right scapular region,shortness of breath, mild headaches, increased sexual desire. I am happy on the drug, but leg cramps,pain in scapular region, shortness of breath are making it miserable. I may stop modafinil due to the side effects"

Was this helpful?YesNo
24 Report

Are you taking this medicine?

  • Ferna...
  • Taken for 1 to 6 months
  • October 31, 2013

"My depression is responsible for a sleeping disorder that makes it very hard for me to stay awake and functional: I have some kind of hypersomnia instead of the regular insomnia complaints patients have. Even though there are people that respond nicely to modafinil, I didn't feel anything while associating 200mg of it to my SSRI. I couldn't notice any improvement to my sleeping cycle or to my concentration. Side effects were absent too. Unfortunately it was not for me."

1 / 10
Was this helpful?YesNo
29 Report
  • Anonymous
  • May 15, 2022

"A complete game changer. I stopped taking modafinil for a few days and became extremely stressed and depressed. Started taking them again and feel amazing. Not sure why everyone isn’t given modafinil instead of anti depressants and other drugs"

10 / 10
Was this helpful?YesNo
8 Report
  • Anonymous
  • May 17, 2009

"I use several antidepressants, and I cannot function without them. Modafinil helped with my chronic fatigue, but it's not an antidepressant in my opinion. I can do a lot of things now. I'm so glad I heard about it. I take 200mg a day."

8 / 10
Was this helpful?YesNo
35 Report
  • Modaftw
  • Taken for 6 months to 1 year
  • August 26, 2021

"Modafinil makes me feel human. I take it for Depression, fatigue, lack of concentration, mood swings. It lifts up my mood and helps me concentrate on my work with single-minded focus. It also helps with my mood swings. I have never once found myself overthinking when I'm on modafinil. It does make me slightly irritable sometimes though. It also helps me be optimistic and enthusiastic about my work."

9 / 10
Was this helpful?YesNo
9 Report
  • upndwn
  • June 27, 2015

"I have been working for many years with one combination after another of medications for bi polar disorder. I was recently on oxcarbazapine and lithium which was great for a few months. Depression came back and I had unpleasant side effects with the oxcarbazapine. My doc added modafanil. It reduced the side effects and improved my depression. It also caused irritability. And caffeine made me restless even with a small amount."

6 / 10
Was this helpful?YesNo
20 Report
  • Tomas
  • Taken for 1 to 6 months
  • August 16, 2021

"It helped me get off of a 50 year history of major depression. Every time I tried to quit Amitriptyline I would have unbearable crushing abdominal pain. My doctor had me try pregabalin. The depression left almost immediately. Fatigue became a problem so he had a 50 mg dose of Modafinil. Now , I no longer need the Pregabalin . Some insomnia occurs but all and all this has been a miracle in my life."

9 / 10
Was this helpful?YesNo
8 Report
  • Chevaz
  • Taken for 2 to 5 years
  • November 10, 2023

"I’ve been using modafinil for years. It has made a big difference in my life. I’m a lot more productive and happy. I go to the gym now almost every day and I’m doing great in my profession. I plan to take it for the rest of my life. The main thing is that I’m not stuck in the negative background noise of the mind. It’s how I imagine a person feels after years of meditation. Rested wakefulness is my best description. I have recently started using Armodafinil. At 250 mg it is more potent and overall is a better deal financially."

10 / 10
Was this helpful?YesNo
2 Report
  • Suit
  • Taken for 6 months to 1 year
  • February 23, 2022

"I have found with NDRI drugs like methylphenidate and drugs like modafinil to induce depression, as someone with Dyslexia and ADHD what I find is that the normal sense of euphoria I gain from normal things like listening to music and just generally being alive is gone which induces a state of depression and suicidal thoughts. I am not finding much on this effect though and I am wondering if its mainly due to dopamine reuptake inhibitors causing the issue entirely. Perhaps my issue is not the lack of dopamine but the conversion of tyrosine into dopamine, I have no idea and I wish I knew because 100mg (200mg+ makes this worse) is very effective for ADHD and Hypersomnia."

7 / 10
Was this helpful?YesNo
4 Report
  • Mackman
  • Taken for 1 to 6 months
  • March 16, 2018

"I concentrate much better, my memory has improved and seem to be much cheerful. Wow, this is an incredible drug. I think I'm gonna go back to College and conquer my classes and get my degree."

9 / 10
Was this helpful?YesNo
45 Report
  • hippy...
  • August 7, 2009

Provigil (modafinil) "I've used it for 10 days now in my most recent attempt to kick meth. It helps so much. It won't buzz you, but it takes away the debilitating lethargy and depression."

7 / 10
Was this helpful?YesNo
85 Report
  • Ambs
  • Taken for 2 to 5 years
  • June 13, 2017

"This medicine really works for depression. It helps me get stuff done and not want to sleep all of the time. Taken with coffee it is a lot stronger. I give this a 9 on a scale of 1-10."

9 / 10
Was this helpful?YesNo
42 Report
  • Candy...
  • Taken for 6 months to 1 year
  • July 10, 2019

"Modafinil has helped some of my friends continue with their daily activities amid depression, and develop for the better. I have seen no side effects so far."

8 / 10
Was this helpful?YesNo
31 Report
  • Kibbles
  • April 14, 2011

Provigil (modafinil) "Most awesome medicine ever made. Non- addictive. Will be used more for MS, MD and Parkinson's is much needed."

10 / 10
Was this helpful?YesNo
64 Report
  • Elon
  • Taken for less than 1 month
  • September 13, 2020

"It makes me more productive and focused. It increased my sex drive for some reason"

9 / 10
Was this helpful?YesNo
21 Report
  • Arch
  • Taken for less than 1 month
  • August 22, 2018

"I got just this and tried it today 200mg and its wonderfully working in 1st day. It's good for depression and for over sleep and laziness. I feel energetic"

10 / 10
Was this helpful?YesNo
29 Report
  • Cotswnw
  • Taken for 1 to 6 months
  • October 23, 2017

"Depressive mood with ability to function well but have noted a significant improvement I mood since prescribed. Thankfully. Have to monitor amount I take and should not mix with strong coffee"

10 / 10
Was this helpful?YesNo
22 Report
  • nick
  • Taken for less than 1 month
  • April 30, 2018

"They should use it more"

9 / 10
Was this helpful?YesNo
18 Report
  • Danny
  • Taken for 2 to 5 years
  • May 3, 2022

"My dose is 200-400mg a day for sleepiness but it had a dramatic effect in my depression I have know had modafinil for 4 years I have been much better in my depressive episodes"

8 / 10
Was this helpful?YesNo
6 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.