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Leuprolide User Reviews & Ratings (Page 2)

Brand names: Lupron, Eligard, Lupron Depot, Camcevi, Lupron Depot-PED Fensolvi

Leuprolide has an average rating of 5.6 out of 10 from a total of 360 reviews on Drugs.com. 42% of reviewers reported a positive experience, while 36% reported a negative experience.

Reviews for Leuprolide

  • Steve
  • Taken for 1 to 6 months
  • January 29, 2021

Eligard (leuprolide) for Prostate Cancer "My side effects from Eligard is extreme bone pain, joint pain, testicular pain, my penis shriveled up like I had jumped in ice water and stayed icy cold for several days, night sweats, night terrors, nightmares, brain fog. I had a CV event 3 days after wound up in the emergency room with extreme difficulty and pain urinating, especially at night. According to the manufacturer this is supposed to be used for palliative care Well I guess they don't know the meaning of palliative care I wish I had never started this treatment"

1 / 10
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  • Dave
  • Taken for 6 months to 1 year
  • September 3, 2018

Eligard (leuprolide) for Prostate Cancer "I was prescribed Eligard by an oncologist due to a suspicion of prostate cancer. I was told my PSA of 80 was almost a certain indication of prostate cancer. Seven months ago, in February I was given a three month injection.. Within an hour I was nauseated. I vomited for three hours. After that the effects of Eligard began to take effect. Hot flashes going from sweating to cold within minutes loss of libido for myself, no sexual satisfaction for my wife. Chest constriction Reduced ability to handle stress Disrupted sleep due to fluctuating temperature. Final comment: I conclude that no man would ever prescribe Eligard to another man if he had taken it himself. It is not a cure for prostate cancer, and it affected my life so negatively, I would never take it again, even if I knew I had cancer, which I don’t. I am writing to the Chief Medical Officer of my province that this drug is a poor choice for any purpose."

3 / 10
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  • Jean
  • Taken for 1 to 2 years
  • April 24, 2019

Eligard (leuprolide) for Prostate Cancer "Been taking Eligard for 5 X every 3 months, just over a year. Prostate out 10 years ago. Radiation 45x about 6 years ago. Eligard effective at reducing PSA. Occasional hot flashes. Tire easily. Often light headed. Little tolerance for BS. More headaches. Breast enlargement. Thinking about stopping use."

4 / 10
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Frequently asked questions

  • Rusty...
  • Taken for 2 to 5 years
  • February 6, 2015

Lupron (leuprolide) for Prostate Cancer "Prostate removed - huge 350 cc- Gleason 7, PSA 15, radiation for 8 weeks, Lupron every 3 months for one year, every 6 months for the next year and a half. PSA has been less than 0.01 since initial radiation. Weakness, memory problems and hot flashes but no cancer. Treatment is worth the side effects. I feel very lucky. "

10 / 10
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  • Tom...
  • Taken for 1 to 6 months
  • May 25, 2019

Eligard (leuprolide) for Prostate Cancer "Been on Eligard for two months and it has taken all the joy out of life. There will be no second injection. My life expectancy is better with cancer than with Eligard and I'm fighting such dark thoughts almost everyday, afraid I'm going to hurt someone, the mood swings are unpredictable and scary. Sex is becoming near impossable all the time."

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Are you taking this medicine?

  • 65...
  • Taken for 6 months to 1 year
  • November 22, 2015

Lupron Depot (leuprolide) for Prostate Cancer "I am experiencing the following side-effects: Breast enlargement, reduction of size of testicles, complete ED, multiple hot flashes hourly, and a mental fog that prevents clear thinking. These were all expected side effects and came as no surprise. Additional unexpected side effects include: rapid pulse rate, elevated BP, breathlessness, short term memory loss, extreme and uncontrollable emotional outbursts (uncontrollable crying over minimally emotional issues), and sleep deprivation (1-2 hours total sleep which could account for the emotional issues). Of additional concern are anecdotal statements by others claiming no reduction of any side effects even after years of removal from follow-up injections of Lupron. My concern is great enough to request suspension of this drug, even at the cost of an elevated PSA with a corresponding resurgence of the cancer. I know there are additional drugs I can take to counteract some of these side-effects, but I would rather not complicate the situation with even more medication. My PSA stands at .3 as of this writing, and I would withdraw my request were it to increase to 4.0, however continued living with this nightmare drug is not my idea of life."

3 / 10
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  • Ber...
  • Taken for less than 1 month
  • May 7, 2014

Lupron Depot (leuprolide) for Uterine Fibroids "I must admit, after reading the commens I was real scared, but I told my self everyone's body reacts differently. May, 6/2014 I took my first shot so far I am feeling great. I was a bit drained before I took the shot, woke up feeling energetic."

7 / 10
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More FAQ

  • Anonymous
  • June 11, 2012

Lupron (leuprolide) for Prostate Cancer "My cancerous prostate was removed when I was 65, 6 years ago. I receive a 22.5 mg Lupron injection about every 3 months. My PSA decreases each time from about 2 to undectable. The injection area is sore for 2-3 days after each injection. I have perhaps a dozen relatively minor hot flashes daily. I take 4 venlafaxine hcl 75 mg tablets daily to curtail hot flashes."

8 / 10
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  • Jensey
  • Taken for 1 to 6 months
  • February 13, 2020

Lupron Depot (leuprolide) for Endometriosis "I feel like I’m one of the few people who has had a POSITIVE experience on the medicine Lupron . I’ve been pain-free from my endometriosis for 3 months, now on my third dose. After my first dose, I had some joint pain and severe hot flashes for a couple weeks, but those symptoms lessened as time went on. My mood has changed for the better while on this medicine, I no longer have pain from the endometriosis, and my only symptom from this medicine are minor hot flashes!! I can’t believe it. This medicine has been a blessing."

10 / 10
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  • mike
  • September 17, 2009

Lupron Depot (leuprolide) for Prostate Cancer "I've been on Lupron (after prostae surgery) for a period of 7-1/2 years. I am also on 50mg Casosex. The side effects are minor (hot sweats, decreased energy) Injection site(s) were moved after 6 yrs. from buttox to shoulder(s) due to lower back pain. I hope this gives hope to patients about to begin this regimen."

10 / 10
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  • lupron...
  • Taken for 1 to 6 months
  • August 25, 2018

Lupron Depot (leuprolide) for Prostate Cancer "I had prostrate cancer 10 yrs ago so they say. 43 treatments of radiation and the PSA is gone. Now 67 years old and my PSA went up to 8.5 10 years later and my doctor wants to do the lupron shot. First one 2 years a big one 45 mg. It almost killed me - I had never been so sick. Now 2 and half years later my PSA was 13 so I told the doc I would try a smaller dose so I did 7.5 a year ago and another 7.5 last week my PSA is 3.2 but still said I should take it. Let me tell you men I WILL NEVER TAKE ANOTHER LUPRON SHOT AS LONG AS I LIVE. The side effects you read about are true, blood pressure problems diabetes. I'm never having lupron shot ever again."

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  • K Sta...
  • Taken for 1 to 6 months
  • September 27, 2019

Lupron Depot (leuprolide) for Prostate Cancer "I was given this poison, for the first time , May 2nd, 2019. The Doctors/nurses would NOT tell me the name of it. Only referred to it as: Hormone Therapy. 60 seconds AFTER the nurse shoved a 22.5mg 3-month dose of it, into my butt....the 'Doctor's assistant, walked up to me , handed me a booklet: 'Understanding Lupron Therapy", said: You better TAKE THIS HOME AND READ IT", she 'laughed, turned around and said: "see ya". When I got home, I turned to the 1st page. It said: "side-effects': "heart attacks, strokes, bone damage, diabetes, AND, "SUDDEN DEATH......" I was so angry. She injected me with a POISON. For 10 weeks, I was l was so angry, mad it was indescribable bad. The "worst 3 months of my life" !"

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  • Lindz
  • Taken for less than 1 month
  • September 30, 2018

Lupron Depot (leuprolide) for Endometriosis "I’m a 24-year-old female who’s suffered from terrible endometriosis pain; my periods left me crumpled up on the ground, moaning in pain, to the point that I seriously wished I were dead. I am not exaggerating in the slightest. Sometimes I’d get really dizzy and hear an intense buzzing in my ears, right before I almost passed out. The pain was unbearable; I often had to miss school and work because of my period. I recently underwent surgery and was recommended Lupron. I read horrible reviews about it for weeks leading up to my doctor appointment and was terrified to try it, but so far I haven’t had any problems other than hot flashes (and that’s MUCH preferable to the agonizing pain I used to be in). Of course, it’s only been a few months since I got the injection, so we’ll see...but so far it’s been great! Don’t let the reviews scare you; if you’re in good health like I am, you probably won’t experience serious complications or side effects. Hope this helps!"

8 / 10
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  • Working...
  • Taken for 1 to 6 months
  • March 19, 2018

Lupron Depot (leuprolide) for Uterine Fibroids "I am 52 (5'8", 155 lbs) w/ large (13 cm) intramural fibroid (fibroid w/in the muscle wall of the uterus). In case I had any adverse reaction to Lupron, decided to take the low dose injection (1 x a month) instead of the single high dose that lasts three months. Felt pretty okay w/ Lupron, other than a dull headache that lingered on for two months (I only had two injections). The actual fibroid did not shrink much after two months (from 13 to 11 cm) but the surgeon said it made the fibroid softer. Had a laparoscopic hysterectomy w/ success. 90% recovered after five days."

6 / 10
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  • bless...
  • Taken for 1 to 6 months
  • December 18, 2012

Lupron (leuprolide) for Prostate Cancer "I got this shot about two years ago. I was told by the urologist that it was a one month shot. I had the shot becaue we wanted some time to research and decide what treatment would be best. Found out later that it was a 3 month shot! Suffered severe side effects! PSA dropped from 13 to 7, but the side effects were NOT worth it! Hot flashes with some of them causing me to nearly pass out were often (20 a day), memory problems, muscle/joint pain and on and on! Once, while teaching I suddenly didn't know where I was or what I was doing! After radiation I was recently put on Trelstar on a MONTHLY basis, nearly the same side effects but NOT the really bad ones!"

3 / 10
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  • Mikey...
  • October 18, 2011

Lupron (leuprolide) for Prostate Cancer "Got a shot of it on Friday, some soreness on Saturday; but saw immediate results of reduced urgency to void every hour, sometimes 4-5 times per hour, depending on consumption of liquid. Some sensitivity to right side of groin and scrotum. Seemed like it might be some blockage in semen tubing or possibly the medication impacting the two lymph nodes that showed some cancer invasion. Now it is Tuesday evening and the sensitivity on the right side groin is minimal. It is really amazing how fast the medication impacted the symptoms. I got a 3 month shot and expect to do a blood draw in 6 weeks to evaluate the impact on the PSA levels. So far so good."

9 / 10
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  • Mr Ch...
  • October 26, 2016

Lupron (leuprolide) for Prostate Cancer "Diagnosed with stage 4 with PC in my right hip. PSA for years was between 2.0 to 3.5. Went from 3.5 to 29 in one year ! I encourage all with a PSA of over 3.0 get a bone density test ! Started Luprone 30 day shot on July 5th 2016. First 3 months went from 29 to 3 so headed in the right direction. Bone pain reduced after first shot by more than 75%. Hot flashes around the clock roughly 10 to 12 a day with a intensity level of about a 5 or 6. Very annoying but tolerable. Miscellaneous aches and pains in joints and muscles. Occasional foggy headed and definitely wake up to much to pee. I'm trying Flo-max now I hope to see some improvement. Fatigue is real! I can't tell if this is harder on my Family than me! So far so good. God Bless to ALL!"

8 / 10
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  • WWII...
  • Taken for less than 1 month
  • August 7, 2014

Lupron Depot (leuprolide) for Prostate Cancer "Had my first injection of Lupron 7.5 mg in July; second injection at the same dosage is set for August 21. So far no hot flashes or side effects. Have been taking Casodex simultaneously (30-day supply) which will end shortly. Only side effect from that initially was fatigue, which resolved after 5 days. Decided to insist on 1-month Lupron injections instead of a 3-6 month extended dose as PC support group participants on the once-a-month dose had far fewer side effects. I'm sticking to my guns on this one; MD tried to give me a 6-month dose right off the bat. I'm switching MDs and glad I did it this way. Hope this helps others."

9 / 10
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  • Ambear
  • November 2, 2015

Lupron Depot (leuprolide) for Endometriosis "I have been taking this for 6 months now, about to start my 7th and I love it! I will say the first month or so, I was really wondering what had I gotten myself into. But now, I am so glad I did it. I take the 1 a month not the 3 months shot. I haven't had a period in 5 months, I haven't cramped in 5 months. I was having hot flashes before I started taking this and I will say that at times they are way worse but I would much rather deal with hot flashes then be huddled over in my bed bc the cramps are so bad that I can't even function. I do understand that some people have bad experiences with things and some people don't It is all up to your body. Everyone's body is different. I hope seeing a good review like this will help."

10 / 10
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  • Anonymous
  • April 18, 2011

Lupron (leuprolide) for Prostate Cancer "Second injection started night and day sweats. This has increased to every 2-3 hrs during the day - less frequency at night. Dropped my PSA from 30 to .07 post prostate removal. Time on medication - 6 months."

10 / 10
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  • Len...
  • July 13, 2016

Lupron (leuprolide) for Prostate Cancer "8 months into Lupron plus Casodex and I am refusing the next 3 month shot. PSA went from 5.7 to .2 to .1 and am just finishing up 9 weeks of radiation. GL scores were mostly 9's but no metastatic found. To say a less common side effect is loss of libido is just plain BS. About a month after the first shot I was done with sex, doc said once the testosterone is gone that's normal. Little aches and pains linger, balls shrink, lost all hair under my arms and slow growing elsewhere. Sometimes seem in a fog mentally. Hot flashes like you wouldn't believe till they offered me other meds, which help somewhat, Put on 5 lbs of blubber below the belly. Lack of energy as well. It works but I think DRs. keep you on it too long for Stage 1 or 2 cancers."

8 / 10
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  • Screw...
  • Taken for 6 months to 1 year
  • October 13, 2020

Eligard (leuprolide) for Prostate Cancer "Husband got Eligard shot to minimize size of prostate to prepare for radiation with 6 month follow up. When he returned the cancer had spread to his bones and PSA went from 32 to 182 in those 6 months with no additional PSA tests given. The shot was ineffective and we were not informed that it could metastasis to other body parts giving us a choice of a different treatment that would not limit his life.... Demand monthly PSAs!!!"

1 / 10
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  • Anony...
  • Taken for 2 to 5 years
  • June 28, 2016

Eligard (leuprolide) for Prostate Cancer "I am the wife of a man currently taking Eligard. I have to say it has worked to keep the prostate cancer from spreading. Which is absolutely wonderful. However it has caused a lot of other problems which has effected both of us. He has absolutely no sexual desire, he has developed which appears to be breast, his penis has become inverted and his testicles have decreased in size. His muscle mass has decreased as well and the weight gain is mostly in his belly. I can only hope that he will regain his man hood if and when he is taken off this medication."

10 / 10
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  • Inline...
  • December 30, 2011

Lupron (leuprolide) for Prostate Cancer "Recently received my first Lupron injection. Within one week my PSA dropped from 69.7 to 11. I have not noticed any severe side effects a of today. I am also starting Alendronate Sodium tablet for healthier bones."

8 / 10
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  • Bill...
  • Taken for 1 to 2 years
  • November 6, 2016

Eligard (leuprolide) for Prostate Cancer "I must say if I only knew what this medication was going to do to me I would of never taken it. At the age of 61 this medication has destroyed my life. After each injection it caused deeper and deeper depression. What at one time brought joy to my life is gone. There is no since of any type of sexuality at all. Nothing brings joy to ones life. after each shot it just makes it worse. The hot flashes are so severe I will have to change my work shirt a couple of times a day. I will soak a shirt with in minuets. One has to remember that the Eligard will get rid of all your hormones. we are not made to run that way and there is no support that will help you deal with that or tell you what to expect. You are no longer male but not female either."

4 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.