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Saphris User Reviews & Ratings (Page 2)

Saphris has an average rating of 7.3 out of 10 from a total of 272 reviews on Drugs.com. 69% of reviewers reported a positive experience, while 18% reported a negative experience.

Reviews for Saphris

  • cpas
  • April 27, 2013

For Bipolar Disorder "I was diagnosed with Bipolar Disorder almost five years ago and have tried just about every medication without success. I have recently started taking Saphris and it is my miracle. My mood swings have gone and I'm no longer angry or depressed. I have plenty of energy (minus the mania) and feel a complete sense of well being. The dissolvable wafers have a very bitter taste however this is a very small price to pay considering how awesome I feel. "

9 / 10
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  • peace...
  • April 10, 2013

For Bipolar Disorder "I just replaced my 75mg nightly Seroquel with 5mg (will probably go to 10) of Saphris. I was very scared to change. I am a successful and happy trauma nurse, mom, partner, etc., even though I do struggle with bipolar disorder and anxiety. My life has been going REALLY well for several years with low doses of Seroquel, Zoloft, and Lamictal, so when my annual spring crazies kind of snuck up on me worse than normal, I was very hesitant to rock the boat. So far this compares VERY FAVORABLY with my Seroquel. I am sleeping well and the morning fog is getting better as my body adjusts. My thinking is clearer and quieter WITHOUT feeling dumb or sad. And I don't seem to be quite as ravenously hungry as on Seroquel. Hope it lasts!"

9 / 10
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  • CattyAK
  • May 4, 2013

For Bipolar Disorder "I've been on Saphris 20mg nightly for 2 months. I have Bipolar Rapid Cyclical with ADHD. This medication is the best. I fall asleep within 10-15 minutes. The horrible taste is a small price to pay. My mood is the most stable it's been in a long time. I'm happy about life, feeling very positive- a huge change for me!"

10 / 10
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  • sunli...
  • June 3, 2010

For Bipolar Disorder "I have been on a truck-load of different medicines to treat Bipolar, Lamictal, Depakote, Lithium, Seroquel, Symbyax, Abilify...just to name a few. Started taking this 10mg/before bed, last week. This does taste horrible, but doesn't cause nausea and vomiting and I'm real sensitive to taste. It makes my tongue go numb for about 30 minutes and during that time I get the munchies really bad. While I'm trying not to eat the house down my mood elevates. I've been getting to sleep a lot easier and staying asleep better. As a whole, I'm feeling better than I have in a long time. Really hoping this medicine works on the long-term for me as I'm tired of trying different ones."

10 / 10
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  • gypsy...
  • Taken for 1 to 2 years
  • May 26, 2013

For Bipolar Disorder "I love Saphris. Best thing that ever happened to me. No other medicine compares. Down side, it's so expensive. I get samples from my psychiatrist, but I will be moving out of state soon and I am so afraid I won't be able to afford Saphris. It's the only medicine that gave me the least amount of side effects and lets me lead a normal life."

10 / 10
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63 Report

Are you taking this medicine?

  • Stpha...
  • Taken for 6 months to 1 year
  • March 3, 2021

For Bipolar Disorder "Currently on 5 mg at night. Best medication so far. Have try risperidone (ptd), invega (weight gain) and latuda (bad anxiety). Only 3 lbs of weight gain...not sure if it's the pandemic or the saphris. The only "side" effect I experienced it the sedative side. It put you right to sleep in 15 minutes which I like ! I wake up after 9 hours sleep without alarm feeling refresh. It tastes bad but I really don't care for the first time of my life I feel good! You should try it"

10 / 10
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  • Finally...
  • September 11, 2017

For Bipolar Disorder "Amazing drug when combined with lexapro ( for my depressive side ). To say it has changed my life, saved my marriage and made me a better father is a sheer undersell of this medicine. I'm bipolar 2 with mixed episodes (Dysphoric). I'm no longer filled with rage over nothing, irritable , or depressed. It has thus far been the magic bullet for me, after trying about 6 other combinations. It's allowing me to be present in my own life without constantly overthinking or having racing and repeating thoughts. Having a clear mind is allowing me the freedom to be the man I always knew I was. There's a lot of horror stories on here but just remember when you find the right medication. Its worth it."

10 / 10
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  • Andrew...
  • Taken for 6 months to 1 year
  • February 19, 2015

For Bipolar Disorder "Been on Saphris for almost a year. Have tried almost all of the others except for Latuda. My experience is that I have had the best dreams and put on the least amount of weight on this medicine. Also, not nearly as drowsy."

10 / 10
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  • coaff
  • September 23, 2015

For Bipolar Disorder "Words can not describe it. The medication has turned my life around. I still can not believe what it has done for me. My mind has slowed down so much without taking away my ability to think sharply. I am truly happy. Anger, irritation, racing thoughts are almost completely gone. I am Bi Polar 1 with GAD and depression. I too am a mixed episode/rapid cycle guy. This med has givin me my life back. I have been shedding anxiety and sleep meds left and right. If you can't afford it, please look to Canada. You can get generic Saphris (asenapine) very, very reasonable. It could well be worth going through a reputable Canadian pharmacy."

10 / 10
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  • Anonymous
  • March 30, 2010

For Schizoaffective Disorder "Wow - this is interesting. First I was scared to try another anti-psychotic as I typically get akathisia, but for some reason I have not had issues with it this time around (so far). I have to say that Saphris works wonders on negative symptoms that most medicines would not really touch. I find myself actually wanting to go outside, and be around people and just do things in general - my lack of desire has just gone. This makes me so much more happier. I just didn't think it was possible, and that I was just stuck the way I was. It tastes nasty though and it numbs your tongue for 15-20 minutes. Also it puts me to sleep. But other than that I have to say the pros definitely do outweigh the cons. I just wish it would come in pill form!"

9 / 10
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  • Katea...
  • September 16, 2015

For Bipolar Disorder "I do not deal with fits of rage anymore nor do I go to extreme lows of sadness and the world is ending. Side effects I had were initially insomnia grogginess after taking the medication and a little bit more hungry. I eat a well-balanced diet with lots of vegetables some fruit high protein and I notice having a snack before taking it helps for hunger pains. I make sure to get regular low impact exercise such as walking. I am now able to be a better mother keep my jobs and feel much much much better mentally. Give it a try at least a month. It has been 3 weeks and I do not have insomnia at night anymore and have dropped 14 pounds. Stay positive don't let side effects get you down!"

10 / 10
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48 Report
  • BAEEEE
  • Taken for less than 1 month
  • March 30, 2015

For Bipolar Disorder "Wonderdrug. I have never, ever had a period of more than two days without irritability without hypomania. Within 2 days of taking this medication, my irritability was nil. I was able to sit in a busy, loud restaurant without getting angry or distracted. I have no sedation during the day, and this medication helps me sleep at night, immediately and deeply. I'm sleeping about 9-10 hours every night, which is why I'm giving it 8 of 10 stars, because that amount of sleep is a little much for me. I still feel a normal range of emotion on this medication, my sex drive is normal, I have no side effects. The taste is not so bad, but tongue does get numb every time I take it, but this wears off by the time I wake up."

8 / 10
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  • Todd...
  • Taken for 1 to 6 months
  • March 18, 2014

For Bipolar Disorder "I believe I have found the answer I have been looking for! Been on it about two months. I sleep throught the night with a lot less interruption and I fall asleep more quickly. My thought pattern is far less anxious and muddled; I am able to concentrate. My mood is far less out of whack and I am generally happy. The only downside for me is it gives me the munchies and I have diabetes, so I have gained some weight a bit rapidly. However, with a lot of effort, I have eliminated foods out of my diet that are carbs. I am starting to level out and I have a lot of hope for the future with this medicine. It is expensive, but I have good insurance."

10 / 10
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  • Bullw...
  • December 3, 2010

For Bipolar Disorder "I've been Bi polar for over 20 years and have tried practically every mood stabilizer and antidepressant there is and some would work for awhile then poop out. Saphris is like a miracle medicine. I don't feel depressed, I have more energy and motivation and my moods are stable. I take one 10 mg tab at bedtime and wake up the next morning feeling alive and ready for the day. I would encourage anyone who is suffering from bipolar depression and mood swings to give this medicine a try. You won't be disappointed. One caveat though is without insurance it is very expensive."

8 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • October 20, 2013

For Bipolar Disorder "I have been taking this for about 4 months now. While I admit I am awful at being consistent with new meds, I am blown away by how well Saphris has consistently toned down my impulsivity, irritation, edginess, suicidal ideations, and cycling depression. Unlike antipsychotics such as lithium, this stuff did not turn me into a walking zombie. I am still able to feel elated, just not so much so that I lose control of myself. Also it helps me have a regular sleeping pattern! I do not know how anyone can taking this in the morning as it knocks me out harder than ambien. The downside of it is that I am experiencing secondary nocturnal enuresis :S It is something I have always struggled with and I would not expect others to experience this."

9 / 10
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  • Anonymous
  • April 25, 2010

For Bipolar Disorder "I started 5mg Saphris 12 days ago and it's UNBELIEVABLE! 20 years ago (on my birthday) I was diagnosed with bipolar that worsened to include severe, treatment- resistant depression. I have done and seen it all - buckets of drugs, ECT and an experimental VNS implant. Mentally, nothing I've tried can touch this stuff! I have also experienced almost every severe physical side effect, and my ADHD-type behavior, noises and shadows are worse (hard to imagine) but I don't think I'll call my doctor on a Sunday. He just gave me 10 of the best days in memory (which is also returning). Will I give piano concerts again? Maybe - if I can play backwards, but I feel so good I could just stand in the corner for the rest of my life."

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  • Stay...
  • Taken for 2 to 5 years
  • September 4, 2019

For Bipolar Disorder "I would really recommend this medication because I’ve tried almost every anti psychotic medication and I’ve never been able to stabilize my mood until I found this medication. The only side effect I get from this medication is twitching on my toes but it goes away a few minutes later. I’ve had worst side effects from Latuda which was making me sedated and giving me milk from my breasts and I wasn’t even pregnant. I really like this medication because it also helps me with sleep and without it I over think a lot at night. My mood has definitely improved with this medication I’ve been taking it for 4 years and it’s worked. I’ve only had to increase the dosage 2 times unlike other medications where I constantly have to increase the dosage."

8 / 10
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  • Anonymous
  • Taken for less than 1 month
  • October 28, 2013

For Post Traumatic Stress Disorder "I waited 3 weeks to write a review cause I was sceptical. After trying so many antidepressant and having the the reversed effect this is the one. I suffer from sever anxiety and PTSD. I take 5mg at night cause it does hit you like a rock. I tried the recommended dose 10mg after a week and it was too much. The taste is annoying but I will deal with that. I am able to concentrate and get things done. I exercise 5xs a week so I have not gained weight. My eating habits are fair so it's diffinatly the exercise. I been trying to find the right drug for 4 years and nothing helped. I do also take klonopin but since I have started saphris it's been reduced it to half of what I used to take. This med has helped me with my anticipatory anxiety"

9 / 10
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  • Almost...
  • Taken for 1 to 2 years
  • December 8, 2013

For Schizophrenia "I was put on Saphris after being on Clozaril for 13 years. My schizophrenia is completely controlled on this medicine. However, it is much less sedating than Clozaril and sleep is sometimes a challenge. It also seems to not increase my appetite-- the first of its kind! For awhile it was also prolonging the QT wave of my heart but that seems to have leveled off. But I do have one major complaint. It sometimes makes me forget how to pronounce words. I guess this is similar to an effect of Topamax. All things said, its good to be almost normal."

9 / 10
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  • jozey
  • November 22, 2013

For Post Traumatic Stress Disorder "I have been on medication for over 23 years and Saphris is a far better antipsychotic I have ever been prescribed. I feel more motivated, more social, my weight hasn't changed and am now enjoying life unlike the many years I spent on Largactil and other antipsychotics. I have also felt benefits in my sleeping pattern. Use this medicine right and you wont believe the change. I have Borderline Personality Disorder and Post Traumatic Stress Disorder but also use an antidepressant too."

10 / 10
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  • Emily...
  • April 23, 2017

For Bipolar Disorder "Worst medication I've ever been on. It has made me very flat, depressed, quiet, overweight, and also a case of anhedonia. I can't even talk to people anymore, just short answers and no enthusiasm. I also don't even enjoy nature anymore and I used to LOVE the outdoors. I've been feeling like a robot ever since I went on it 6 months ago. I know I should have told my doctor sooner. Last week I started dosing down and am praying that once I'm completely off of it I'll be feeling better and hope to have more life in me. I'm glad to see that it works for most people. Has anyone else experienced any of these side effects?"

1 / 10
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  • mcadams
  • August 11, 2013

For Bipolar Disorder "Saphris has helped me more than any other medication (which were many, many over 12 years). I was blown away by the benefit and bewildered that it took so long for someone to prescribe it. I still don't have the strength and energy that I need but I am functioning at 80% to 90%. Before it was barely hanging on with suicidal periods. Savella was another good medication for me but not quite this good. The racing thoughts, paranoia, and insomnia are gone. I usually fall asleep within 15 minutes of lying down. Although I am having some nights of waking up after 3 hours. Just getting to sleep earlier and getting the required sleep I need has made a tremendous difference in how I function and cope. My side effect has been arthritis and weight gain."

9 / 10
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  • Mitch
  • September 19, 2017

For Bipolar Disorder "After trying several meds, which helped, I was introduced to Saphris @ 10mg/day. I experienced periods debilitating drowsiness, so decreased to 5mg. Problem disappeared. Mentally, emotionally I feel almost normal. Mood swings are slight, handleable. I like Saphris."

10 / 10
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  • Kris...
  • Taken for less than 1 month
  • November 30, 2014

For Post Traumatic Stress Disorder "I'm sleeping for the 1st time in YEARS without the screaming-clawing-gasping-horrors (the thing people refer to as "nightmares"). Waking up was the worst part. Waking up found me in a dead panic, or a blood-red rage, unable to function. Nothing helped, some things made me worse. I have been labeled "medication resistant" because nothing helped & I'd given up. No med-of-the-month for me. I've been suicidal for awhile, but hadn't told anyone. Had a breakdown while with Mom. I called my shrink, put her on speakerphone, & she called in a prescription for Saphris. I stayed with Mom. We got the medicine. Starting calming with the 1st dose. I now remember what sleep & rest feel like! Cleared my head. I still have my artistic creativity, too! "

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • August 31, 2012

For Bipolar Disorder "I have been severely depressed since birth of my child 5 years ago. I have been put on every medication out for depression and mood stability. This medicine is the best. I have not felt this good in years."

10 / 10
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52 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.