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Adapalene topical User Reviews & Ratings (Page 5)

Brand names: Differin, Plixda

Adapalene topical has an average rating of 6.3 out of 10 from a total of 508 reviews on Drugs.com. 56% of reviewers reported a positive experience, while 32% reported a negative experience.

Reviews for Adapalene topical

  • kathr...
  • November 8, 2016

Differin (adapalene) for Acne "I have had a horrible experience with this cream. my face is so painfully dry even in the spots I didn't put the cream. my eyes, the crease under my lip, my nose and the corners of my lips are so dry there is now even blisters developing. It hurts to put anything on besides coconut oil but that's not helping and I am at a loss."

1 / 10
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  • Anonymous
  • December 7, 2008

Differin (adapalene) for Acne "This medication helped to clear up my acne within the first couple of weeks of use. However, I think my body developed a resistance to the active ingredient, and some (not all) of the acne returned. The severity of the acne was much less than before treatment. One negative side effect I experienced was increased sensitivity and a red rash that extended down my neck. What ever you do, do not get your eyebrows waxed while using this product. My skin was ripped off with my eyebrows when I had them waxed."

8 / 10
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  • Prisc...
  • Taken for 1 to 2 years
  • February 11, 2015

Differin (adapalene) for Acne "I used Differin and the first month was HORRIBLE. I guess I needed to use moisturizer especially SPF.. Or lotion. I got sun burned really bad all over, my face was peeling and really scabby. I just looked crazy going to school. And my face hurt so bad so I started using it less. I even went to go get my eyebrows waxed and the wax was too hot for my face and sensitive skin it ripped and scabbed up really bad.. Ouch! But luckily after one month was suffering my face and especially my nose (where I got it) it was all clear, gone, and smooth! Seems like similar experiences where it starts off bad then ends up good. I now put Olay SPF moisturizer on everyday and use it every other day with Cerave face wash."

8 / 10
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27 Report

Frequently asked questions

  • Tee
  • October 22, 2016

Differin (adapalene) for Acne "Started differin almost 2 months ago. I had some cystic on the chin and some pimples on the cheeks before starting differin (i.e, mild acne). 3 weeks after starting differin, I started to get a bunch of whiteheads on one side of my cheek. It wasn't that noticeable until 1-2 weeks (4-5 weeks in) that the whiteheads became incredibly noticeable - very raised, incredibly itchy. The whiteheads eventually became pimples, meaning that I had 5-6 pimples in this little patch. Worst acne I have ever had (I am assuming this is the initial breakout period). 8 weeks on differin now, and that one side and spot of my cheek that had all those whiteheads has cleared up >50%. Can't wait to see what happens in the next 2 weeks! Hopefully acne free!"

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  • Anonymous
  • Taken for less than 1 month
  • January 20, 2013

For Acne "This has helped me a lot! I started using Adapalene Gel 0.1% (prescribed by my doctor) only last week and my acne has gotten much better. I get lots of redness in between my eyebrows, pimples on my forehead, little (not severe at all) bumps around my nose, and I have scars on my chin. Now, the problem around my nose is completely gone and the scars on my chin are hardly visible. In between my eyebrows is less red and my forehead is starting to clear up. I hope that in a couple of weeks it will almost be gone! Side effects include dryness around the applied area and itchiness or irritating spots under or on the corner of your eyes. I apply it at night after washing my face and rinse it off in the morning. I love this product!"

9 / 10
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Are you taking this medicine?

  • Kitty...
  • Taken for 1 to 6 months
  • September 15, 2016

Differin (adapalene) for Acne "I've had a great experience with Differin gel. I was prescribed Differin for acne that got worse as an adult. When I was 31, the acne was so severe that I felt like a teenager. The first week was hard. My skin was very dry to the point where flakes would fall off when I touched my face. I used moisturizer in the morning, and would still flake all day. After about a week, the dryness completely went away. I've been using this product for a few weeks now and have seen a HUGE difference in my skin. My acne is clearing up, and my skin has a smoothness that it has never had before. My skin is combination/oily, and it feels a little oilier now. I'm okay with that - with the smoothness of my skin, it looks dewy and clear."

10 / 10
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  • Bear
  • Taken for 6 months to 1 year
  • March 20, 2019

Differin (adapalene) for Acne "My dermatologist prescribed this before it was OTC and it may have been a higher dose then, but it still works with the 1%. I do not have severe acne, but it is cystic especially around my menstrual cycle. What I have learned to use and what my doctor recommended was to only use dove sensitive soap with the product. I wash my face with it before I apply it. You want to be sure to use it on your entire face, not just particular spots here and there. Sometimes I could even wear it under my makeup, but at night is easiest for me, once a day. Anyways, when my skin did get really dry my solution is always Vaseline, all over your face for one night maybe two. It's messy and feels very gross but worth it. I always have baby soft skin without dryness and my wrinkles are less present after a night of this. Lastly, although I do still get cystic acne still on differin it's less often and they come out more easily if and when I do pop them. Hope this is helpful."

8 / 10
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  • Kristin
  • August 12, 2016

Differin (adapalene) for Acne "This has worked wonders! A little rough for the first couple months, but even then my cystic acne lessened and the pimples I did have were raised and easy to get rid of. Stick it out for 3-4 months and you'll see!"

9 / 10
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  • Saman...
  • September 22, 2015

Differin (adapalene) for Acne "A dermatologist (a different dermatologist than I usually see) recommended to start using Differin along with taking my Doxycycline. I have been using the topical gel for 3 days on my face and back and I only have negative things to say. My face is peeling badly and the skin is very red and irritated. I have tried different moisturizers and they just burn. The outer corners of my eyes are red and painful. My back broke out with large blister-like pimples. I do not have sensitive skin and my acne is not very bad. I feel this product has actually worsened my condition. I am going to stop using Differin immediately. I don't know how long it's going to take my skin to heal."

1 / 10
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  • JoePot
  • February 7, 2017

Differin (adapalene) for Acne "Its been over a month using the over the counter. I posted previously. I had started out using once every three days and then went to every two days to make sure no issues. Skin got very dry at first. Apply each evening about two hours before going to bed. In the AM I apply Neutrogena Oil-Free Moisture with Sunscreen SPF 35 and re-apply as needed. Had several blackheads mature during the month. Some were under the skin surface. All gone. A few whiteheads. Skin has calmed down considerable. Skin seems healthier. No longer use Benzoyl Peroxide."

10 / 10
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  • kano
  • March 5, 2016

Differin (adapalene) for Acne "acne has been a problem for me since 8th grade & I started using Differin my first day of senior year (major mistake due to it making your skin "purge" the first couple of days//weeks" by the end of October my skin was mostly clear & by the beginning of December my face was completely clear except for the occasional pimple every once in a blue moon. At the beginning it would make my skin burn especially during sports. It's sensitive to sun to defenitely use sunscreen when you're out. All around miracle medicine."

10 / 10
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  • laylow
  • Taken for less than 1 month
  • May 16, 2015

Differin (adapalene) for Acne "I only started using differin a week ago. It has made my skin very red like in the first 3 days I got a red rash-like thing below my lips and on my cheeks and it burns. It also has made around my eyes very dry. I am going to start using it every second day for my skin to get used to it but I really hope that it will work. Just give it time people and don't over use or get worried if your skin becomes red because that is a side effect if you have sensitive skin."

3 / 10
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  • Zam
  • Taken for 1 to 6 months
  • July 5, 2019

Differin (adapalene) for Acne "I am 34 years old and female. For the past 6ish years I started getting breakouts. Sometimes they're terrible. I get painful deep pimples, cystic acne, blackheads. About 7 months ago I started realizing how bad my scarring was getting. NOTHING WORKED THAT I TRIED. Well maybe for a few days it would work. But nothing ever consistently worked. I tried salicylic acid, benzoyl peroxide, all at different doses with moisturizer toners etc. Anyway when I tried Differin it did not start working for a few weeks. Maybe 2-3 weeks. But I kept doing it. Initially the side effects are facial redness and skin flaking. I pushed through that part of it and my breakouts STOPPED. Like completely stopped. I will start to get minor break outs if I skip a few days of Differin. Once I begin again, it starts working again. I always use a good moisturizer in the morning when I wake up and I apply the differin at night. This stuff is awesome for acne and it really works."

10 / 10
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  • Senio...
  • Taken for 1 to 6 months
  • May 19, 2020

Differin (adapalene) for Acne "I am 42 years old and I have fair skin. Recently, I have had the worst Acne Rosacea outbreak I have ever had in my life. After a few months of antibiotic and soolantra cream, the inflammation and new pimples were getting better. But, I still had rough, bumpy skin with lots of red hyperpigmentation where the acne has been. My dermatologist ordered Azelic Acid and I waited for over a month for it to come in at the pharmacy. It didn’t they claim because of Covid19. I was furious and cancelled my order. I decided to buy Differin to help skin turnover and prevent new pimples. My skin is so smooth! I have used it every night except 1 night for a month. The redness has improved and if I get new pimples, they go away quickly. I never got the purge. I am wondering if antibiotics helped with that. Also, my skin seemed dry for a minute, but it was my skin getting ready to slough off. Overall, I believe the product is doing a fine job. I also use Cera VE Day and night moisturizer recommended by my doctor."

9 / 10
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  • Car
  • September 25, 2018

Differin (adapalene) for Acne "I purchased this product after seeing the commercial for it several times. I had tried everything OTC and thought that this might actually work.. it didn’t. I’ve had moderate acne for about 5 years, and it always comes in spurts. I really didn’t notice anything the first week of using it. In the second week I noticed my acne getting worse, and by the third week my acne was unbearable. I had the worst acne of my life and so I finally did research because I hadn’t before I started. All the reviews I read said that it gets worse before it gets better, but usually starts really working after a month or so. I decided to stick with it and kept hoping it would get better. It didn’t. After 12 weeks of using it my acne was awful. I had developed more scars than I ever had before. I threw it away and went back to my old routine. My face started clearing up right away. Everyone has different reactions, but I wouldn’t recommend this product to any of my friends."

1 / 10
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  • Meg
  • November 1, 2013

Differin (adapalene) for Acne "I've been using this gel for probably about 2 or 3 years now. I started getting acne in around 6th grade where as I didn't start my period until 9th grade. I've never had SEVERE acne, there's just always been at least a couple zits on my face for as long as I can remember. I had no significant peeling or dryness when I started using differin, and I also had no immediate results. Slowly over time, however, my acne is becoming less severe and less often. Maybe it's because of the differin, maybe it's because I'm growing out of it. I did stop using it last summer as a test and my skin got worse and worse for the entire month I stopped using it and it took a solid 3-4 months after I started using it again for my skin to return back to normal."

7 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • July 15, 2019

Differin (adapalene) for Acne "30, male, extremely oily skin. I had cystic acne and I have some of the worst scars, and now I get the occasional huge cyst/pimple. I rotate my use of this daily. one day cheeks, one day forehead, one day nose, kind of like that, because all over every day, even a thin layer, it burns cause its too potent. On this I realized my brow ridge and nose produced less oil, and they look less "congested". I've been on it 3 months now, for the first time I've healed a cyst without a scar in my life. There are absolutely less lines on my forehead, my nose gets no cysts and looks smoother like my forehead. To prep skin for dryness this causes I use the Cereve PM moisturizer before Differin. It just dries me out too much on bare skin. I also use SPF 50 daily on my face. I live in an area with a high uv index all year."

10 / 10
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  • CS_mom
  • Taken for 6 months to 1 year
  • November 17, 2019

Differin (adapalene) for Acne "I have used Retinol for years, recently switched and gave Differin a try. I purged, and then waited, and waited. My skin was a mess for months. I couldn’t ever get it happy or calm, even after the purge period. Deep cystic acne combined with these weird superficial blemishes that I’ve never had. This is honestly one of the worst products I’ve ever used for my occasional hormonal acne and fine lines. I’ll stick with glycolic acid and retinol from now on."

2 / 10
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  • lv14
  • Taken for 1 to 6 months
  • August 30, 2021

Differin (adapalene) for Acne "Tried Differin for almost 4 months. In that period of time it totally ruined my skin. I started with a few pimples and now my face is completely covered. It has absolutely destroyed my self esteem. I can hardly look at myself in the mirror. I see people stare at the sides of my face and it is so hard on me. A kid even asked if ants had bit me. Tonight I'm done with this stuff"

1 / 10
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  • JoePot
  • January 3, 2017

Differin (adapalene) for Acne "Using the over the counter product for just a few weeks. Oily skin has always been a major problem. Seems to have knocked down excess skin oil big time. I apply early evening. I use it with Neutrogena Oil-Free Moisture with Sunscreen SPF 35. Been in the sun and no burning or dryness noted. Did the beach yesterday for about an hour, no problem. I first started using every third day after reading a number of postings. Thought I ease into it as some reported issues using daily right off the bat. No issues. Did notice dryness of the skin before using my moisturizer. Just went to every other day. The skin has calmed down and a few flare ups that were just not going away are clearing. End of the week I plan on daily use."

10 / 10
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  • JimJa...
  • August 25, 2010

Differin (adapalene) for Acne "I started getting a few to many zits the summer starting after freshman year in college (that summer is just about to end) so I started using Differin. A full 10 weeks later I see pretty darn good results (there is less acne and the zits that are there are smaller). It does get worse before it gets better though. Week 2-6 were hell. I didn't have severe acne (or that close to severe) to begin with, but I wanted to clear my face as much as possible, and in a week and a half when school starts back I will be well into my 12th week and I think it's entirely possible that I could be completely clear by then. I also have been taking 65mg extended release Solodyn (minocycline) the entire time as well as Differin."

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  • Chris...
  • Taken for 1 to 6 months
  • November 30, 2019

Differin (adapalene) for Acne "The purge I experienced lasted in two different waves from end of week 2 to week 6. Yikes. However, the acne from it was no worse than what I had been dealing with already on some of my worse breakouts. I seemed to be able to combat inflammation by using a benzoyl peroxide face wash and aloe vera gel as part of my routine. For me personally, dryness and skin flaking was far worse than the purge. It took about 7 weeks for my skin to adjust to adapalene, and even with two moisturizers layered on, I had the worst dryness and slight irritation. That said, once I hit 8 weeks, noticeable improvements started happening. About half of my comedones are gone, dryness is now manageable, and hyperpigmentation scars are starting to fade a little bit. I expect all of these areas to keep improving now that I'm getting closer to the 12 week mark. This was a process that had growing pains, but I am so glad to have stuck with it. Be patient, it will reward you!"

7 / 10
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  • Amber...
  • Taken for less than 1 month
  • May 7, 2017

Differin (adapalene) for Acne "I've only been using this for about 5 days and I can already see very clear results! It says to not expect anything till 2 weeks but with my skin it seemed to start working overnight because the next day it was already clearer and scars had faded a bit! Bearing in mind I have very very mild acne not very noticeable just wanted this cream to prevent from getting worse. Will keep you guys updated :) would definitely recommend this for oily skin with some blackheads and mild acne or moderate acne."

10 / 10
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  • Bella
  • March 29, 2017

Differin (adapalene) for Acne "I've been using this product for 5 weeks now. Before this, I have mild acne on the forehead and cheeks. I went to dermatologist and the specialist prescribed me this product to apply on my entire face every night for 2 months. And after 1 week using this adapalene cream, my acne gets worse and worse. Pimples keep popping out everywhere on my face even on areas that have never had pimples before. I am still using it because it does says on the brochure that the product's effect may be seen after 8 weeks. I'm using Aiken Tea Tree Oil for my pimples so that they will 'shrink' and heal quickly. So for the time being, I'm just gonna bear with all the acne on my face and wait for miracles of Differin Adapalene cream to work."

3 / 10
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  • Jess
  • January 26, 2017

Differin (adapalene) for Acne "After benzoyl peroxide made my skin worse, I was prescribed differin cream 0.1%. Results were slow at first but with maintaining a good skincare routine and healthy diet my skin showed huge improvements after about 2-3 months of use. Little side effects, some dryness but as to be expected with any acne product and easily resolved with moisturiser. Felt a lot less harsh on my skin than benzoyl peroxide. I am left with some spots and scarring but the effects have been overall brilliant. Would reccommend sticking with it for a few months to see best results!"

8 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.