How long does it take to feel normal again after stopping this med? I was taking 25 mg of Myrbetriq for IC/OAB for about 7 weeks. After the first few weeks, I started having insomnia and anxiety in the middle of the night. I attributed it to stopping amitriptyline a few weeks before. However, the insomnia and anxiety persisted. I started finding that it was the Myrbetriq causing this. I stopped this medication 8 days ago and my pharmacist said it would take 10 days to be completely out of my system. I feel horrible. No improvement from side effects. Not like myself. I get up in the mornings and my heart rate is over 90 just waking up! The anxiety is horrible and I feel sad about feeling so bad that I have asked my doctor to refer me to psychiatry. Looking for some hope.