Skip to main content

Zoloft (sertraline): An Overview of Depression and Clinical Uses for Sertraline

A brief description of how to recognize depression and FDA-approved uses for sertraline

Video transcript

>> Hello and welcome to "VideoScript", presented by

Today in the first of three presentations, we are reviewing Zoloft, an antidepressant known by the generic name of sertraline.

Sertraline is a commonly used antidepressant in the class of drugs known as selective serotonin reuptake inhibitors, or SSRIs.

SSRIs are the most commonly prescribed class of antidepressants in the US. They are effective and well tolerated for most patients. Many SSRIs are now available in generic form which makes them more affordable.

Other commonly used drugs in this class include fluoxetine, or paroxetine, and escitalopram, also known by the brand names Prozac, Paxil and Lexapro.

Depression is the 4th leading cause of disease in the US and afflicts 7 out of every 100 US adults. It is not unusual to feel sad or blue at times, but with major depressive disorder patients experience a severely depressed mood and activity level that persists for two weeks or more.

Symptoms of major depression can interfere with daily functioning and work, and can cause hardship for both the patient and family.

Major depression includes at least 4 of the following symptoms:
changes in appetite, sleep, or sexual drive; feelings of guilt or worthlessness; impaired concentration, increased agitation, loss of interest in activities, increased fatigue, or thoughts of suicide.

Antidepressants such as sertraline may be prescribed for other uses besides depression. In adults, FDA-approved indications for sertraline also include obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, premenstrual dysphoric disorder, and social phobia.

The only FDA-approved use for sertraline in children is for treatment of obsessive-compulsive disorder. Sertraline is not approved for the treatment of depression in children.

Thank you for joining us at for a brief review of sertraline. Please refer to our patient and professional information, drug interaction checker, and additional tools on

Patients with a concern about the use of sertraline should consult with their health care provider.

Visit for more information

Recommended videos

Zoloft (sertraline): Mechanism, Clinical Trials, and Dosing

An overview of how sertraline works in depression, clinical study data, and general dosing tips

Zoloft (sertraline): A Review of Important Precautions and Side Effects

Tips for patients and their caregivers on how to safely use sertraline, and an overview of common side effects

Irritable Bowel Syndrome: Symptoms and Diet Tips

A description of the different types of irritable bowel syndrome (IBS), diet tips to help lessen symptoms, and possible drug therapy.


This animation shows a catheter being inserted into the heart where alcohol is injected causing the swollen ventricle wall to shrink.

Hamstring curl with resistance tubing

The hamstring curl with resistance tubing targets the back of the thigh. See how it's done.

Browse by category

By medication