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Vetmedin 5 mg Capsules (Canada)

This page contains information on Vetmedin 5 mg Capsules for veterinary use.
The information provided typically includes the following:
  • Vetmedin 5 mg Capsules Indications
  • Warnings and cautions for Vetmedin 5 mg Capsules
  • Direction and dosage information for Vetmedin 5 mg Capsules

Vetmedin 5 mg Capsules

This treatment applies to the following species:
Manufacturer: Boehringer

1.25 mg, 2.5 mg, 5.0 mg capsules for dogs


Vetmedin® 1.25 mg capsule contains 1.25 mg pimobendan.

Vetmedin® 2.5 mg capsule contains 2.5 mg pimobendan.

Vetmedin® 5 mg capsule contains 5 mg pimobendan.


Pimobendan, a benzimidazole-pyridazinone derivative, is a non-sympathomimetic, non-glycoside inotropic substance with potent vasodilatative properties.


Pimobendan exerts its stimulatory myocardial effect by a dual mechanism of action: increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (type III).

It also exhibits a vasodilating action through an inhibitory action on phosphodiesterase III activity. Following oral administration of Vetmedin® capsules, the absolute bioavailability of the active principle is 60-63%. Mean plasma protein binding is 93%. The plasma elimination half-life of pimobendan is approximately 30 minutes and the main active metabolite elimination half-life is approximately 2 hours. Almost the entire dose is eliminated via feces.

The tolerance of pimobendan has been evaluated in pre-clinical studies in healthy Beagle dogs with non-diseased hearts. Daily intravenous administration of pimobendan at dosages of 0.5 mg/kg to 8.0 mg/kg over a period of 2 to 4 weeks was associated with exaggerated myocardial contractility and jet lesions to the myocardium. These intravenous dosages are equivalent to one-time oral dosages of 0.8 mg/kg to 12.8 mg/kg. Lesions were not seen at intravenous dosages of 0.25 mg/kg (equivalent to 0.4 mg/kg orally) administered over a 2 to 4 week period.

Vetmedin 5 mg Capsules Indications: Dogs

For the treatment of congestive heart failure originating from dilated cardiomyopathy or valvular insufficiency. It is recommended that the diagnosis of congestive heart failure be confirmed by radiographs or diuretic responsiveness.

Treatment should be initiated only in symptomatic cases which will benefit from increased myocardial contractility (positive inotropy).

Vetmedin 5 mg Capsules Dosage And Administration

Vetmedin® capsules should be administered orally at a dose range of 0.2 mg to 0.6 mg pimobendan/kg body weight per day. The preferable daily dose is 0.5 mg pimobendan/kg body weight. The dose should be divided into two administrations (0.25 mg/kg each), one half of the dose in the morning and the other half approximately 12 hours later. Each dose should be given approximately one hour before feeding.

Vetmedin® capsules may be combined with a diuretic treatment such as furosemide.

Vetmedin 5 mg Capsules Caution

Atrial fibrillation occurs commonly in cases of congestive heart failure and indicates a more guarded prognosis. According to good veterinary practice, dogs with congestive heart failure should be monitored for presence of arrhythmias during cardiac therapy. Appropriate anti-arrhythmic should be initiated if indicated.


Vetmedin® capsules should not be used in cases of hypertrophic cardiomyopathies or clinical conditions where an augmentation of cardiac output is not possible for functional or anatomical reasons (e.g. aortic stenosis).

Use During Pregnancy And Lactation

In studies with rats and rabbits, pimobendan had no effect on fertility and embryotoxic effects only occurred in maternotoxic doses. In rat experiments it has been shown that pimobendan is excreted into milk.

Therefore, Vetmedin® capsules should only be administered to pregnant and lactating bitches if the expected therapeutic benefits overweigh the potential risk.

Drug Interactions

There is always a risk of drug interactions when using multiple medications in a compromised or geriatric patient. Use with caution with other positive inotropes. As pimobendan is highly protein-bound, monitor carefully if using other drugs with high protein binding. Concurrent use of beta-blockers or calcium-channel blockers may decrease pimobendan-induced effects on myocardial contractility.

Side Effects

Pimobendan administered as an overdose orally may result in profuse vomiting. Patients should be treated symptomatically.

The following suspected adverse effects have been reported following clinical use.

Cardiovascular: Tachycardia (may be dose dependent and avoided by reducing the dose).

Gastrointestinal: Vomiting, diarrhea, inappetance.

Nervous system/Behavioural: Uneasiness, incoordination, convulsions.

Renal: Polyuria, polydypsia.


If poisoning occurs, contact a doctor or Poisons Information Center.

Store below 25°C. Keep the container tightly closed.

Boehringer Ingelheim (Canada) Ltd., Burlington, Ontario L7L 5H4





1.25 mg

100 capsules


2.5 mg

100 capsules


5 mg

100 capsules


NAC No.: 12300501

Customer Care No.:   800-567-1885
Technical Services No.:   1-877-565-5501
Every effort has been made to ensure the accuracy of the Vetmedin 5 mg Capsules information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-05-30