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This page contains information on TSV-2 for veterinary use.
The information provided typically includes the following:
  • TSV-2 Indications
  • Warnings and cautions for TSV-2
  • Direction and dosage information for TSV-2


This treatment applies to the following species:
Company: Zoetis

Bovine Rhinotracheitis-Parainfluenza3 Vaccine, Modified Live Virus

U.S. Vet. Lic. No.: 190


The vaccine is prepared by growing attenuated virus strains on a bovine cell line. The virus fractions are combined and stabilized by freeze-drying. A sterile diluent is supplied for rehydration.

Contains gentamicin as preservative.

TSV-2 Indications

TSV-2® is for vaccination of healthy cattle, including pregnant cows, as an aid in preventing infectious bovine rhinotracheitis caused by infectious bovine rhinotracheitis (IBR) virus and disease caused by parainfluenza3 (PI3) virus.

Directions For Use

1. General Directions: Vaccination of healthy cattle, including pregnant cows, is recommended. Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, shake well, and administer 2 mL intranasally using a cannula or a syringe with the needle removed. Place half the dose (1 mL) in each nostril.

2. Primary Vaccination: Administer a single 2-mL dose to healthy cattle. Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization.

3. Revaccination: Annual revaccination with a single dose is recommended.

4. Good animal husbandry and herd health management practices should be employed.

Precaution(s): Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

Use entire contents when first opened.

Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

Burn containers and all unused contents.

Caution(s): As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.

Warning(s): Do not vaccinate within 21 days before slaughter.

For veterinary use only.

Discussion: TSV-2® is unique in that the virus strains it contains are temperature-specific. Tests have shown that they will not grow in vivo at or above 39°C,1 the normal bovine body temperature. This restricts viral replication to the nasal mucosa, which is constantly ventilated and maintained at temperatures less than 39°C, even in the febrile animal. At this localized site, the temperature-specific viruses replicate and stimulate local and systemic immunity.2 Because the temperature-specific strains cannot grow in the internal body organs or developing fetus, pregnant cows may be safely vaccinated. Stimulation of a localized immune response also results in a rapid onset of protection.3,4

Disease Description: IBR is a prevalent viral respiratory disease characterized by fever, nasal discharge, conjunctivitis, a hyperemic muzzle (“red nose”), coughing, and increased respiration. In pregnant cows, IBR virus can also cause abortions.

PI3 is a common viral respiratory infection, sometimes mild or inapparent, but often associated with bovine respiratory disease complex.

Trial Data: Safety and Efficacy: Safety of the temperature-specific IBR strain was demonstrated in a test where it was administered to 1,019 pregnant cows in 12 herds.5 No abortions attributed to IBR were observed. In a controlled challenge-of-immunity test, 5 of 5 susceptible vaccinates were protected from a virulent IBR challenge that clinically affected all 5 nonvaccinated control calves. In a second challenge-of-immunity test, all 25 vaccinated calves were protected from a virulent PI3 challenge that produced clinical signs or temperature increase in 6 of 7 nonvaccinated control calves. In an onset-of-protection study, 2 pairs of susceptible calves remained clinically normal when subjected to contact challenge 72 and 48 hours after vaccination with virulent IBR virus. One calf challenged 24 hours postvaccination remained normal, another exhibited mild clinical signs. All control calves and calves used for contact challenge were clinically affected.4


Available upon request.


Presentation: 1 dose, 10 dose, and 25 dose vials.

CPN: 36900412

Telephone:   269-359-4414
Customer Service:   888-963-8471
Every effort has been made to ensure the accuracy of the TSV-2 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2022 Animalytix LLC. Updated: 2021-11-29