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Trivetrin (Canada)

This page contains information on Trivetrin for veterinary use.
The information provided typically includes the following:
  • Trivetrin Indications
  • Warnings and cautions for Trivetrin
  • Direction and dosage information for Trivetrin


This treatment applies to the following species:
Manufacturer: Merck Animal Health

Trimethoprim and Sulfadoxine Injection

Sterile Antibacterial

For Veterinary Use Only

DIN 02145995


The active ingredients of TRIVETRIN are a combination of trimethoprim and sulfadoxine which has been established in a ratio of 1:5.


TRIVETRIN Injection contains trimethoprim, a synthetic antibacterial developed in the Wellcome Research Laboratories, and sulfadoxine, a sulfonamide. The two components of TRIVETRIN produce a sequential double blockade of bacterial metabolism, giving a level of activity many times greater than that obtained from either drug alone.

TRIVETRIN provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.

TRIVETRIN has shown activity in vitro against the following organisms:

Very sensitive organisms: Escherichia coli, Clostridium spp., Shigella spp., Salmonella spp., Proteus mirabilis, Bacillus anthracis, Pasteurella spp., Haemophilus influenzae, Streptococcus zooepidemicus, Vibrio spp.

Sensitive organisms: Streptococcus viridans, Brucella spp., Enterococci spp., Staphylococcus aureus including penicillinase-producing organisms, Klebsiella spp., Proteus spp., Actinomyces spp., Corynebacterium spp., Bordetella spp., Neisseria spp.

Moderately sensitive organisms: Enterobacter aerogenes, Nocardia spp.

Non-sensitive organisms: Pseudomonas aeruginosa , Mycobacterium tuberculosis, Leptospira spp., Erysipelothrix rhusiopathiae

usually non-sensitive.

Trivetrin Indications And Clinical Uses

TRIVETRIN Injection may be used in cattle and swine where potent systemic antibacterial action against a wide range of infections caused by sensitive organisms is required.

TRIVETRIN Injection is indicated in cattle for the treatment of:

Respiratory tract infections-bacterial pneumonias including bovine pneumonic pasteurellosis (shipping fever).

Alimentary tract infections-primarily enteric and septicemic colibacillosis and salmonellosis.

Other infections-infectious pododermatitis (foot rot, foul in the foot) and septicemias.

TRIVETRIN Injection is indicated in swine for the treatment of:

Respiratory tract infections-bacterial pneumonias.

Alimentary tract infections-colibacillosis and post-weaning scours.

Other infections-mastitis-metritis-agalactia syndrome of sows (MMA) and bacterial arthritis.


TRIVETRIN Injection should not be used in cattle or swine showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.

Adverse Reactions

No significant adverse reactions have been reported.


With intravenous therapy generally, and sulfonamides in particular, hypersensitivity reactions can occur and should be appropriately treated with corticosteroids or epinephrine.

Temporary, local, irritating swellings are encountered occasionally after intramuscular injection of TRIVETRIN.


Milk taken from treated animals within 96 hours after the latest treatment must not be used in food. Treated animals must not be slaughtered for use in food for at least 10 days after the latest treatment with this drug.

Trivetrin Dosage And Administration

TRIVETRIN Injection should be administered at a dose rate of 16 mg/kg bodyweight (3 mL per 45 kg [100 lb]) daily. In piglets weighing less than 4.5 kg (10 lb), do not exceed a dose of 0.5 mL.

Intramuscular injection is recommended for cattle and swine, but if a particularly rapid response is required in acute infections TRIVETRIN can be administered by slow intravenous injection.

Treatment should continue for 2-3 days after symptoms have subsided. The usual course of treatment is for not longer than 5 consecutive days.

Dosage Form

TRIVETRIN Injection is a solution containing 4% w/v trimethoprim and 20% w/v sulfadoxine in an organic solvent. Each mL contains 40 mg trimethoprim and 200 mg sulfadoxine.

Full details of TRIVETRIN Injection are contained in the Product Monograph which is available on request.

Imported by Intervet Canada Corp., 16750, route Transcanadienne, Kirkland QC, H9H 4M7

For technical enquiries, call toll free 1 888 306-0069.


Product Code:

100 mL


250 mL


500 mL


1742020B R1197

® Registered trademark of Schering-Plough Animal Health Corporation, used under license by Intervet Canada Corp.

NAC No.: 12080905

Intervet Canada Corp.

Order Desk:   514-428-7013
Toll-Free:   866-683-7838
Fax:   Toll-free 888-498-4444; local 514-428-7014
Every effort has been made to ensure the accuracy of the Trivetrin information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2018 Animalytix LLC. Updated: 2018-11-30