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Tribrissen 24% (Canada)

This page contains information on Tribrissen 24% for veterinary use.
The information provided typically includes the following:
  • Tribrissen 24% Indications
  • Warnings and cautions for Tribrissen 24%
  • Direction and dosage information for Tribrissen 24%

Tribrissen 24%

This treatment applies to the following species:
Manufacturer: Merck Animal Health

Trimethoprim and Sulfadiazine Sterile Injection


For Veterinary Use Only

DIN 02146053


The active ingredients of TRIBRISSEN are a combination of trimethoprim and sulfadiazine which has been established in a ratio of 1:5.


TRIBRISSEN 24% contains trimethoprim, a synthetic antibacterial, and sulfadiazine, a sulfonamide.

The two components of TRIBRISSEN produce a sequential double blockade of bacterial metabolism, giving a level of activity many times greater than that obtained from either drug alone.

TRIBRISSEN provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.

Tribrissen 24% Indications And Clinical Use

TRIBRISSEN has shown activity in vitro against the following organisms:

Very Sensitive Organisms:

Escherichia coli, Shigella spp., Proteus mirabilis, Pasteurella spp., Streptococcus zooepidemicus, Clostridium spp., Salmonella spp., Bacillus anthracis, Haemophilus influenzae, Vibrio spp.

Sensitive Organisms:

Streptococcus viridans, Enterococcus spp., Klebsiella spp., Proteus spp., Corynebacterium spp., Neisseria spp., Brucella spp., Staphylococcus aureus including penicillinase-producing organisms, Actinomyces, Bordetella spp.

Moderately Sensitive Organisms:

Enterobacter aerogenes, Nocardia spp.

Non-sensitive Organisms:

Pseudomonas aeruginosa , Leptospira spp., Mycobacterium tuberculosis, Erysipelothrix rhusiopathiae

usually non-sensitive

The following organisms were isolated in clinical trials and were shown to be susceptible to treatment with TRIBRISSEN:

Cats: Escherichia spp., Enterobacter spp., Klebsiella spp., Streptococcus spp., and Staphylococcus spp.

Dogs: Escherichia spp., Enterobacter spp., Klebsiella spp., Streptococcus spp., Staphylococcus spp., Bacillus spp. and Proteus spp.

TRIBRISSEN 24% is indicated for the following infections when caused by susceptible strains of the above organisms:

Cats: Alimentary tract infections, Respiratory tract infections, Soft tissue infections including wounds and abscesses.

Dogs: Alimentary tract infections, Respiratory tract infections, Skin and soft tissue infections including interdigital abscesses and wounds.


TRIBRISSEN should not be used in animals showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.

Adverse Reactions

No significant adverse reactions have been reported.

Tribrissen 24% Dosage And Administration

Shake the vial well before use.

TRIBRISSEN 24% should be administered to dogs and cats subcutaneously at the rate of 1 mL per 17 lb (8.0 kg) bodyweight daily, or 0.06 mL/lb (0.45 kg).

The schedule below provides for the optimal dose of 30 mg/kg per day (14 mg/lb per day).


2 kg (5 lb) - 0.3 mL

4 kg (10 lb) - 0.6 mL

7 kg (15 lb) - 0.9 mL

9 kg (20 lb) - 1.2 mL

14 kg (30 lb) - 1.8 mL

18 kg (40 lb) - 2.4 mL

23 kg (50 lb) - 3.0 mL

27 kg (60 lb) - 3.6 mL

32 kg (70 lb) - 4.2 mL

36 kg (80 lb) - 4.8 mL

41 kg (90 lb) - 5.4 mL

45 kg (100 lb) - 6.0 mL

50 kg (110 lb) - 6.6 mL

55 kg (120 lb) - 7.2 mL

59 kg (130 lb) - 7.8 mL

64 kg (140 lb) - 8.4 mL

68 kg (150 lb) - 9.0 mL

The recommended dose may be given once daily. Alternatively, especially in severe infections, the initial dose may be followed by half the recommended daily dose every 12 hours.

TRIBRISSEN 24% should be administered for 2-3 days after symptoms have subsided. Do not extend therapy for more than 14 consecutive days.

Tribrissen 24% Caution

Prolonged dosage in cats may lead to changes in thyroid function. Do not continue therapy in cats for more than 14 days. Do not exceed the recommended daily therapeutic dose.

Dosage Form

TRIBRISSEN 24% is an aqueous suspension of trimethoprim in a solution of the sodium salt of sulfadiazine.

Each mL contains 40 mg trimethoprim and 200 mg sulfadiazine.


Store between 15 and 30°C.

Protect from light.


50 mL Vial - Product code: 0067004

® Registered trademark of Schering-Plough Animal Health Corporation, used under license by Intervet Canada Corp.

Intervet Canada Corp., 16750, route Transcanadienne, Kirkland QC, H9H 4M7

For technical enquiries, call toll free 1 888 306-0069.


CND 3382/2

AU 00/01

NAC No.: 12080854

Intervet Canada Corp.

Order Desk:   514-428-7013
Toll-Free:   866-683-7838
Fax:   Toll-free 888-498-4444; local 514-428-7014
Every effort has been made to ensure the accuracy of the Tribrissen 24% information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-01-04