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Tissumend II

This page contains information on Tissumend II for veterinary use.
The information provided typically includes the following:
  • Tissumend II Indications
  • Warnings and cautions for Tissumend II
  • Direction and dosage information for Tissumend II

Tissumend II

This treatment applies to the following species:
Manufacturer: V.P.L.


(a methoxypropyl cyanoacrylate composition)

Description And Function:

TISSUMEND II Synthetic Absorbable Tissue Adhesive is a patented, unique absorbable composition consisting of a methoxypropyl cyanoacrylate monomer, polymeric modifiers, and D&C Violet #2 FDA approved dye.

TISSUMEND II has the following advantages over current cyanoacrylate adhesives: TISSUMEND II is broken down by hydrolysis and eventually absorbed. Reduced exothermic properties upon polymerizing resulting in reduced cytotoxicity and enhanced tissue acceptance. Forms an exceptional adhesive joint that is favorably compliant with tissue. Delivered in a surgeon-friendly package.

TISSUMEND II polymerizes forming a strong bond between most tissue surfaces within 10 seconds after application. TISSUMEND II provides the surgeon hemostatic properties in combination with superior adhesive qualities.

TISSUMEND II is indicated for the closure of surgical wounds, declaws, tall dockings, incision sites, debrided trauma wounds, hemostasis and laser surgical procedures.


TISSUMEND II is contraindicated in the management of infected wounds or situations where tissue closure would be detrimental to the patient. This product is not intended for intravenous administration or other routes of administration other than topical application.

Tissumend II Caution:

To be used by or under the supervision of a licensed veterinarian and is not intended for human application.


Overapplication of TISSUMEND II may result in unpredictable healing. Avoid contact with clothing since the stain may be permanent. Avoid contact with metal instruments. If adhesive accidentally gets in the eye, the eyelids should be kept open and the eye surface thoroughly washed with water.


Package should be stored under refrigeration. After pouch has been opened, remaining pipettes should be stored in pouch under refrigeration to avoid exposure to heat and humidity. Avoid prolonged exposure of TISSUMEND II to temperatures above 32°C (90°F). The product should not be used beyond the indicated expiration date.

Accidental Application:

Tissumend II may be removed from surfaces with chloroform, dimethylsulfoxide or acetone. These removal agents should not be used in situations that may cause injury or harm to the patient.

How Supplied:

Product code: 3002931, TISSUMEND II Synthetic Absorbable Tissue Adhesive is supplied in individual prefilled pipettes (0.2mL). Each box contains 5 individual nitrogen flooded pouches containing 4 pipettes each.


1. Site Preparation: The surgical site should be prepared in an appropriate manner. The surgical site should be dried before application to ensure fluids do not interfere with polymerization of TISSUMEND II.

2. After the pipette has reached room temperature, the pipette should be cut off near the distal end of the tube.

a. Declaws:

i. The claw should be removed using standard techniques.

ii. Excess blood should be removed before application.

iii. Apply a very thin coat to one edge of the tissue, making sure to avoid over-application.

iv. Wound edges should be brought together for 10 seconds with firm pressure.

v. Apply bandages in a standard manner.

b. Incisions:

i. Excess blood should be removed before application.

ii. Apply a very thin coat to one edge of the tissue, making sure to avoid over-application.

iii. Wound edges should be brought together for 10 seconds with firm pressure.

iv. Apply bandages in a standard manner.

v. Large incisions (>2 inches) or incisions with high physical stress may require suturing.

For multiple applications, portions of the pipette tip may be aseptically trimmed. DO NOT OVER-APPLY TISSUMEND II. A light thin coat is better than a thick, heavy coat.


For information, please call 1-888-241-9545.

©2002 Veterinary Products Laboratories

RM #: 2004678, 2003912, 2003913

02-1345, 03-0939

U.S. Patent No. 6,299,631

NAC No.: 11430690

Distributed by PRN PHARMACAL
Telephone:   850-478-2770
Order Desk:   800-874-9764
Fax:   850-476-7087
Every effort has been made to ensure the accuracy of the Tissumend II information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 Animalytix LLC. Updated: 2018-09-28