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Synovex T40

This page contains information on Synovex T40 for veterinary use.
The information provided typically includes the following:
  • Synovex T40 Indications
  • Warnings and cautions for Synovex T40
  • Direction and dosage information for Synovex T40

Synovex T40

This treatment applies to the following species:
Company: Zoetis

(trenbolone acetate and estradiol)

40 mg trenbolone acetate and 8 mg estradiol per implant


ANADA 200-367, Approved by FDA



Synovex T40 (trenbolone acetate and estradiol) is an implant containing 40 mg of trenbolone acetate and 8 mg of estradiol. Each implant consists of 2 small yellow pellets. Ten implants are provided in a cartridge.

DOSAGE: One implant containing 40 mg of trenbolone acetate and 8 mg of estradiol is administered to each animal. The 2 pellets that make up the dosage of Synovex T40 are contained in one division of the multiple dose cartridge. The ten-dose cartridge of Synovex T40 is designed to be used exclusively with a Synovex SX10 gun.

ROUTE OF ADMINISTRATION: The implant is placed under the skin on the posterior aspect of the ear by means of an implanting device available from Zoetis Inc.

NOTE: Never sacrifice careful, clean technique for speed of implantation.

How To Implant

For Use With The Synovex Sx10 Gun

Study the following instructions carefully, then proceed step by step, until the technique becomes routine. Many head can be implanted per hour by an experienced team, one member of which should be assigned to do nothing but the implantation. Care should be taken to insure the hands of the person administering the implant are clean and only sanitary instruments are used.


Increases rate of weight gain in pasture cattle (slaughter, stocker and feeder steers and heifers) in a slow release delivery system.

Do not use in veal calves. Effectiveness and animal safety in veal calves have not been established.


Store unopened product at controlled room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F).

Avoid excessive heat and humidity.

Use product before the expiration date printed on the label.

Once the pouch is opened, unused product may be stored in the end-folded pouch (away from light) for up to six months under refrigerated conditions 2°-8°C (36°-47°F) or at room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F) for up to one month.


Not to be used in animals intended for subsequent breeding or in dairy animals. Not for use in humans. For animal use only. Implant pellets in ear only. Any other location is a violation of Federal law. Do not attempt salvage of implanted site for human or animal food.

A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Keep this and all drugs out of the reach of children.

Restricted Drug (California)-Use Only as Directed.

Step 1 Loading The Sx10 Gun

Load the SX10 gun following the directions outlined in the instruction manual accompanying each SX10 gun.

Step 2 Restraint

The animal must be confined in a restraint mechanism (squeeze chute or head gate). The implant site on the back of the ear should be prepared by scrubbing with firm bristled brush that has been soaked in a germicidal solution.

Note: If implanting horned cattle, greater safety is provided when the head is controlled by the use of a bull lead (nose tongs).

Step 3 Implant Site

Divide the ear into three imaginary sections as illustrated. The implanted pellets should be deposited in the center one-third of the ear as shown. To accomplish this, the SX10 gun needle should be inserted in the outer one-third of the ear as indicated by the “X” in the illustration. Implanting too close to the head may cause abnormal sexual behavior. Care should be taken to avoid severing the major arteries of the ear.

Step 4 Insert Needle

Grasp the ear with one hand. Holding the SX10 gun firmly with the other hand, penetrate the skin at the point shown by the “X”. Thrust the needle under the skin taking care not to penetrate the cartilage. Ease the SX10 gun forward (toward the base of the ear) until the full needle length is beneath the skin.

Step 5 Pellet Implantation

When the needle is completely inserted, activate the instrument by squeezing the trigger completely. Do not withdraw the needle, but allow the automatic needle retractor to release the pellets. This will allow the pellets to be deposited in a straight line in the path of the retracted needle.

Step 6 Inspection

Check the implant site. If properly administered, the implants should lie in a straight line under the skin.

Re-cock the gun by grasping the barrel with your left hand and lifting the cocking bolt with your right hand. Fully retract the bolt to the rear of the device. Then, return the bolt forward to its locked position. Disinfect the SX10 gun needle in a germicidal solution. The SX10 gun is now ready to implant the next animal.

NET CONTENTS: One pouch contains ten 10-dose cartridges (100 implants).


Each Cartridge Contains 10 implants (100 implants total)

Manufactured By A Non-Sterilizing Process

Distributed by: Zoetis Inc., Kalamazoo, MI 49007




CPN: 3690404.0

Telephone:   269-359-4414
Customer Service:   888-963-8471
Every effort has been made to ensure the accuracy of the Synovex T40 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-02-06