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SupraSulfa III Cattle Bolus

This page contains information on SupraSulfa III Cattle Bolus for veterinary use.
The information provided typically includes the following:
  • SupraSulfa III Cattle Bolus Indications
  • Warnings and cautions for SupraSulfa III Cattle Bolus
  • Direction and dosage information for SupraSulfa III Cattle Bolus

SupraSulfa III Cattle Bolus

This treatment applies to the following species:
Manufacturer: AgriPharm


SMSR 6-80-8

Oral Antibacterial

NADA 140-270, Approved by FDA

SupraSulfa III® (Sulfamethazine Sustained Release Bolus) is indicated for the treatment of the following diseases in beef cattle and non-lactating dairy cattle: Pasteurella spp.; bacterial pneumonia associated with Pasteurella spp.; necrotic pododermatitis (foot-rot) and calf diphtheria caused by Fusobacterium necrophorum; coccidiosis (bacterial scours) caused by Escherichia coli; coccidiosis caused by Eimeria bovis and E zuernii; acute mastitis caused by Streptococcus spp. (beef cattle only); acute metritis caused by Streptococcus spp.

Dosage and Administration

SupraSulfa III (Sulfamethazine Sustained Release Bolus) should be administered at the rate of 150 mg/lb body weight on the first day of treatment. Each bolus will treat 200 lbs of body weight. The bolus is scored to allow breaking for more accurate dosing, however, it must not be crushed. The bolus should be lubricated prior to administration and care taken to ensure the entire dose has been swallowed. Observe animal following dosing to ensure regurgitation does not occur. If regurgitation occurs, clean regurgitated material and readminister, if this is not practical, administer a new bolus.

Dosage Schedule:

Body Weight

No. Boluses

Body Weight

No. Boluses

200 lbs


700 lbs


300 lbs


800 lbs


400 lbs


900 lbs


500 lbs


1000 lbs


600 lbs


1000 lbs


NOTE: SupraSulfa III (Sulfamethazine Sustained Release Bolus) is designed to provide a therapeutic sulfamethazine level in approximately 6 hours, and persist in providing this level for 72 hours (3 days). After 72 hours, all animals should be re-examined for persistence of observable disease signs. If signs are present, consult a veterinarian. If signs of disease are significantly reduced, it is recommended that a second dose be given to provide an additional 72 hours of therapy. No further doses should be administered.



30 grams

SupraSulfa III Cattle Bolus Caution

This drug, like all sulfonamides, may cause toxic reactions and irreparable injury unless administered with adequate and continuous supervision. Follow the recommended dosages carefully. Fluid intake must be adequate at all times throughout the three day therapy provided by the sustained release bolus. If symptoms persist after using this preparation for 3 days, consult your veterinarian.


Do not use in female dairy cattle 20 months of age or older. Use of sulfamethazine in this class of cattle may cause milk residues. Do not use in calves under one (1) month of age or calves being fed an all milk diet. Use in these classes of calves may cause violative tissue residues to remain beyond the withdrawal time. Animals intended for human consumption must not be treated within 8 days of slaughtering.

For Animal Use Only


Keep out of the reach of children.

Distributed by: Western Veterinary Supply Inc., Porterville, Calif. 93257 U.S.A.

Mfd. in U.S.A.

DSL-1707 9505

NAC No.: 14570980

822 7TH STREET, SUITE 605, GREELEY, CO, 80631
Telephone:   817-859-3000
Every effort has been made to ensure the accuracy of the SupraSulfa III Cattle Bolus information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-04-26