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Supra Sulfa III Calf Bolus

This page contains information on Supra Sulfa III Calf Bolus for veterinary use.
The information provided typically includes the following:
  • Supra Sulfa III Calf Bolus Indications
  • Warnings and cautions for Supra Sulfa III Calf Bolus
  • Direction and dosage information for Supra Sulfa III Calf Bolus

Supra Sulfa III Calf Bolus

This treatment applies to the following species:
Manufacturer: Aspen

Antibacterial Sulfamethazine Sustained Release Calf Bolus (72 Hours)

Restricted Drug (California) - Use Only as Directed

For Animal Use Only

Keep Out of Reach of Children

NADA 120-615, Approved by FDA


Sulfamethazine (Formulated in a sustained release base)

123.8 grains (8.02 grams)

Supra Sulfa® III Calf Boluses (Sulfamethazine Sustained Release Boluses) are intended for oral administration to ruminating replacement calves (calves over one (1) month old that are not on an all-milk diet). Supra Sulfa® III Calf Boluses are indicated for the treatment of the following diseases when caused by one or more of the following pathogenic organisms sensitive to sulfamethazine: Bacterial Pneumonia (Pasteurella spp.), Colibacillosis (Bacterial Scours) (E. coli) and Calf Diphtheria (Fusobacterium necrophorum).

RESIDUE WARNING: Treated animals intended for human consumption should not be slaughtered for food for at least 12 days after the last dose. Exceeding two (2) consecutive doses may cause violative tissue residues to remain beyond the withdrawal time. Do not use in calves under one (1) month of age or calves being fed an all-milk diet. Use in these classes of calves may cause violative residues to remain beyond the withdrawal time. Do not use in female dairy cattle 20 months of age or older. Use of sulfamethazine in this class of cattle may cause milk residues.

Dosage and Administration

Supra Sulfa® III Calf Boluses (Sulfamethazine Sustained Release Boluses) are designed to be administered orally to ruminating replacement calves. (See RESIDUE WARNING Statement). Supra Sulfa® III Calf Boluses should be given according to the following dosage schedule:

No. of Boluses

Animal Body Wgt


100 lbs.


150 lbs.


200 lbs.


250 lbs.


300 lbs.

This bolus may be divided for better approximation of the correct dose; however, care should be taken not to crush the bolus. Care should also be taken to ensure the entire dose has been swallowed by the animal. Observe animals following the administration to ensure boluses are not regurgitated. Lubricate bolus before dosing animals.

Supra Sulfa® III Calf Boluses are designed to provide a therapeutic sulfamethazine level in approximately 6 hours, and persist in providing this level for 72 hours (3 days). After 72 hours, all animals should be re-examined for persistence of observable disease signs. If signs are present, consult a veterinarian. It is strongly recommended that a second dose be given to provide for an additional 72 hours of therapy, particularly in those more severe cases. The above schedule should be used at each 72-hour interval.

Supra Sulfa III Calf Bolus Caution

This drug, like all sulfonamides, may cause toxic reactions and irreparable injury unless administered with adequate and continuous supervision. Follow recommended dosages carefully. Fluid intake must be adequate at all times throughout the three-day therapy provided by the sustained release bolus. This product has not been shown to be effective for non-ruminating calves.

Store at 20°-25°C (68°-77°F), with excursions permitted to 15°-30°C (59°-86°F).

Manufactured for: Aspen Veterinary Resources,® Ltd., Liberty, MO 64068, USA


Product No.:


25 Boluses


8SUS024 Rev: 07/15

A256B Rev. 07/15

50 Boluses


8SUS028 Rev: 07/15

A257B Rev. 07/15

CPN: 1475139.2

Telephone:   816-415-4324
Fax:   816-415-4314
Every effort has been made to ensure the accuracy of the Supra Sulfa III Calf Bolus information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2019 Animalytix LLC. Updated: 2019-01-22