The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.
Sodium BicarbonateThis page contains information on Sodium Bicarbonate for veterinary use.
The information provided typically includes the following:
- Sodium Bicarbonate Indications
- Warnings and cautions for Sodium Bicarbonate
- Direction and dosage information for Sodium Bicarbonate
Sodium BicarbonateThis treatment applies to the following species:
SODIUM BICARBONATE INJECTION
8.4% (100 mEq. in each 100 cc)
(pH 7.0 - 8.0)
Sodium Bicarbonate Injection is a sterile solution containing 8.4% sodium bicarbonate with a pH of 7.0 to 8.0.
Each 100 ml. contains 8400 mg. of sodium bicarbonate (100 mEq.).
ACTIONS: Acidosis is a result of an elevated concentration of hydrogen ions in the body fluids, which can result from three conditions.
1. Respiratory acidosis caused by the retention of carbon dioxide.
2. Metabolic acidosis resulting from an accumulation of acid metabolites from metabolic disorders.
3. Renal acidosis caused by an inadequate excretion of hydrogen ions by the kidneys.
The administration of any sodium bicarbonate injection preparation directly increases the bicarbonate content of the plasma.
Sodium Bicarbonate Indications
(1) Respiratory acidosis caused by the retention of carbon dioxide. (2) Metabolic acidosis resulting from an accumulation of acid metabolites from metabolic disorders. (3) Renal acidosis caused by an inadequate excretion of hydrogen ions by the kidneys.
Alkalosis, especially respiratory alkalosis, convulsions or congestive heart failure.
WarningNot for multiple dose use. Use only if the solution is clear. Any opened or unused portions should be discarded immediately. Sodium bicarbonate injection should not be boiled.
PrecautionsRapid injection of Sodium Bicarbonate may be extremely dangerous and may cause death by severe derangement of intra or extra-cellular ionic concentrations. Hypertonic solutions must be employed with special care. In general, 1 or more liters of isotonic sodium bicarbonate may be administered to relieve acidosis. Because of the possibility of producing alkalosis by over-correction of the bicarbonate deficit, repeated fractional doses should be used. Thus, the actual total amount of sodium bicarbonate given is governed by the successive clinical response in patients to each repeated fractional dose. Once the severe symptoms have been controlled, the size of each fractional dose and the frequency of administration should be decreased in order to gradually restore normal bicarbonate levels.
Caution should be exercised in patients with oliguria or anuria so that excessive retention of sodium will not occur.
DOSAGE & ADMINISTRATION: If the carbon dioxide content of the plasma is unknown, an average dose would be 1 ml. of undiluted sodium bicarbonate injection per pound of body weight administered in a liter of 5% Dextrose, or isotonic saline, or other appropriate fluid therapy vehicle. The concentration of the bicarbonate solution and the route of administration is determined by the need of the patient. Undiluted Sodium Bicarbonate Injection may be administered intravenously slowly and with caution, or following dilution to isotonicity (1.5%). For intravenous administration suitable concentrations range from isotonic (1.5%) to undiluted (8.4%), depending upon the clinical conditions and the requirements of the patient.
For subcutaneous injection, an isotonic solution (1.5%) of sodium bicarbonate injection can be prepared by diluting one part of the product with five to six parts of sterile water.
A general average dose for all species may be: 1 ml. of Sodium Bicarbonate Injection per pound of body weight administered intravenously, slowly with caution or diluted in an adequate quantity of intravenous fluid therapy solutions, e.g.: Sodium Chloride Injection (0.9%), 5% Dextrose Injection.
OVERDOSE: Should alkalosis result from bicarbonate administration, the use of sodium bicarbonate should be stopped and the patient treated according to the degree of alkalosis. Sodium chloride injection (0.9%) intravenously is usually sufficient to restore plasma chloride levels. If alkalosis is severe, i.e. accompanied by hyperirritability or tetany, intravenous ammonium chloride (NH4Cl) may be given as a 1/6 molar solution (167 mEq./l.). Calcium gluconate may also be useful in controlling tetany.
Sodium Bicarbonate Caution
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
How Supplied100 ml. single dose vials. 500 ml. single dose vials.
NOTE: The sterility of this product conforms to U.S.P. membrane testing methods.
Store at temperatures between 15° to 30°C (59°-86°F).
For Veterinary Use Only
KEEP OUT OF THE REACH OF CHILDREN
Made in Canada
Manufactured by: Dispar Int’l Laboratories Ltd, Joliette, Quebec, Canada J6E 3Z1
Manufactured for: BUTLER ANIMAL HEALTH SUPPLY, DUBLIN, OHIO 43017
NAC No.: 10821643
A Henry Schein Company
400 METRO PLACE NORTH, DUBLIN, OH, 43017-7545
|Every effort has been made to ensure the accuracy of the Sodium Bicarbonate information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.|
Copyright © 2020 Animalytix LLC. Updated: 2020-09-29