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This page contains information on S-706 for veterinary use.
The information provided typically includes the following:
  • S-706 Indications
  • Warnings and cautions for S-706
  • Direction and dosage information for S-706


This treatment applies to the following species:
Manufacturer: Merial Select


Live Virus

S-706 Indications

This vaccine contains the live bursal disease virus for the vaccination of healthy chickens at one day of age by the subcutaneous route or at seven days of age or older by drinking water or coarse aerosol spray as an aid in the prevention of infectious bursal disease. It is essential that the chickens be maintained under good environmental conditions and that exposure to disease viruses be reduced as much as possible.

Store vaccine at 35-45°F (2-7°C). Do not freeze. Do not vaccinate within 21 days of slaughter. Use entire vial contents when first opened. Burn the container and all unused contents. Contains streptomycin sulfate and penicillin as bacteriostatic agents and Amphotericin B as a fungistatic agent.

Preparation Of Vaccine For Subcutaneous Injection

IMPORTANT: Sterilize vaccinating equipment by autoclaving 15 minutes at 121°C or by boiling in water for 20 minutes. Never allow any chemical disinfectant to come in contact with vaccinating equipment.

1. For each 1,000 doses of vaccine, use 200 ml of sterile diluent.

2. Do not open and rehydrate the vaccine until ready to start vaccinating.

3. Tear off the aluminum seal from a bottle of diluent and remove the stopper.

4. Using a sterile syringe, remove 2 ml of diluent and add to the dried vaccine.

5. Allow the vaccine to dissolve, and transfer the dissolved vaccine back into the bottle of diluent.

6. Rinse the vaccine vial to be sure of removing all the vaccine.

7. Replace the stopper and thoroughly mix the vaccine and diluent by swirling and inverting.

8. Use the vaccine-diluent mixture immediately as described below.


1. Use a sterile automatic syringe with a 20-22 gauge, 3/8-1/2 inch needle that is set to accurately deliver 0.2 ml. Check the accuracy of delivery several times during the vaccination procedure.

2. Dilute the vaccine only as directed, observing all precautions and warnings for handling.

3. Keep the bottle of diluted vaccine in an ice bath and agitate continuously.

4. Hold the chicken by the back of the neck, just below the head. The loose skin in this area is raised by gently pinching with the thumb and forefinger. Insert the needle beneath the skin in a direction away from the head. Inject 0.2 ml per chicken. Avoid hitting the muscles and bones in the neck.

5. Use entire contents of bottle within one hour after mixing.

Directions For Addition Of Blue Dye To Sterile Diluent

Blue dye may be aseptically added to sterile diluent using the following procedures:

1. Dye mixing chart:

Bag/bottle diluent size

200 ml
400 ml
600 ml
800 ml

1200 ml
1600 ml

1800 ml
2400 ml

Blue Dye to be added

0.5 ml

1.0 ml

1.5 ml

2. Swab top of rubber stoppers on dye vial and diluent container with alcohol; let dry.

3. Using a sterile syringe and needle, withdraw the contents of the vial.

4. Inject dye into diluent container and mix well.

5. Only Merial Select’s vaccines may be used with this diluent. Add vaccine according to the manufacturer’s recommendations.

6. Properly dispose of the dye container and any unused contents at the end of the day.

Drinking Water Vaccination Using Pouring Application

Drinking water vaccination is recommended for healthy chickens seven days of age or older.

1. Remove all medications, sanitizers and disinfectants from the drinking water 72 hours (three days) prior to vaccination.

2. Provide sufficient waterers so that all the chickens can drink at one time. Shut off water supply and allow chickens to consume all the water in the lines.

3. Raise water lines above the chickens’ heads. Clean and rinse the waterers thoroughly.

4. Withhold all water from the chickens for a minimum of two hours in warm weather to four hours in cool weather prior to vaccination to stimulate thirst. Withdrawal time should be reduced if half-house brooding is in process.

5. Do not open or mix vaccine until ready to vaccinate.

6. Drinking water for vaccine delivery should contain one ounce (29 gram) of non-fat dry milk per gallon (3.8 liters) of non-chlorinated water, or should contain milk product based stabilizer prepared according to the manufacturer’s instructions.

7. Reconstitute the vaccine in 3 gallons (11 liters) of milk-water during cool weather or 4 gallons (15 liters) of milk-water during warm weather for each 1,000 doses.

8. Distribute vaccine solution among waterers. Avoid direct sunlight.

9. Lower waterers and allow the chickens to drink freely. Add the remaining vaccine solution to the water lines as the chickens drink.

10. Do not provide additional drinking water until all the vaccine is consumed.

Drinking Water Vaccination Using Proportioner Application

Drinking water vaccination is recommended for healthy chickens seven days of age or older. Several types of medicator/proportioners are commercially available. Set proportioner to deliver one ounce (30 ml) of vaccine concentrate per one gallon (3.8 liters) of water.

1. Remove all medications, sanitizers and disinfectants from the drinking water 72 hours (three days) prior to vaccination.

2. Clean all containers, hoses and waterers prior to vaccination.

3. Withhold all water from the chickens for a minimum of two hours in warm weather to four hours in cool weather prior to vaccination to stimulate thirst. Withdrawal time should be reduced if half-house brooding is in process.

4. Do not open or mix vaccine until ready to vaccinate.

5. Calculate to supply vaccine solution at a rate of 3 gallons (11 liters) per 1,000 chickens in cool weather and 4 gallons (15 liters) per 1,000 chickens in warm weather. The age of the chickens should be considered when calculating water supply. Always use nonchlorinated water when vaccinating chickens.


2,500 chickens in cool weather x 3 gallons (11 liters) = 7.5 gallons (27.5 liters).

2,500 chickens in warm weather x 4 gallons (15 liters) = 10 gallons (37.5 liters).

6. Prepare vaccine stock solution as follows:

a. Determine the quantity of vaccine concentrate required by multiplying one ounce (30 ml) x gallons of water needed for vaccine/drinking water.


For 2,500 chickens: 7.5 gallons x 1 ounce (30 ml) = 7.5 ounces (225 ml).

b. Add 3 ounces (85 gm) of non-fat dry milk per 16 ounces (480 ml) of cool water, or use a commercial milk product based stabilizer according to the manufacturer’s instructions. For 2,500 chickens add 1.25 ounces (40 gm) non-fat dry milk to the 7.5 ounces (225 ml) of water.

c. Reconstitute the dried vaccine with the milk solution. Rinse the vaccine vial to remove all the vaccine.

7. Insert proportioner hose into the vaccine stock solution and start water flow. Continue until all solution has been consumed before changing water supply to direct flow.

8. Do not medicate or use disinfectants for 24 hours after vaccination.

Coarse Aerosol Spray Application

Coarse aerosol spray application is recommended for vaccination of healthy chickens seven days of age or older.

Use a sprayer delivering a coarse aerosol spray pattern to dispense rehydrated vaccine quickly and evenly throughout a house of chickens. Do not use vaccinating equipment for any other purpose.

1. Prior to spraying, reduce air flow by raising curtains or stopping fans. Air movement should be limited for 20 minutes following vaccination.

2. Do not open or mix vaccine until ready to vaccinate.

3. Fill vaccine container with cool, distilled water.

4. Pour reconstituted vaccine into a clean container and add 5 ounces (150 ml) of cool water for each 1,000 chickens to be vaccinated.

5. Place the vaccine solution into spray canister and walk through the house spraying at the rate of 1,000 chickens per minute. Aim spray directly above the heads of the chickens.

6. Avoid direct contact with the vaccine solution. Wear goggles and mask while spraying.


Do not vaccinate diseased chickens. Vaccinate all chickens on the premises at one time. Administer a minimum of one dose per chicken. Avoid stress conditions during and following vaccination. Do not place chickens in contaminated facilities. Exposure to disease must be minimized as much as possible. For veterinary use only.


Merial Select’s vaccines have met the requirements of the USDA in regard to safety, purity, and potency. This vaccine has been tested by the Master Seed immunogenicity test for efficacy.

S-706 Caution

The capability of this vaccine to produce satisfactory results depends upon many factors, including - but not limited to - conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of individual chickens, and degree of field exposure. Therefore, directions for use should be followed carefully. The use of this vaccine is subject to applicable state and federal laws and regulations.


MERIAL SELECT, INC. Gainesville, GA 30503 USA

U.S. Vet. License No. 279

Product Codes GD-1510, GD-1570, GD-1590, GD-1520, GD-1550, and GD-1540

X-1M/JX-2M/S-2.5M/T-5M/U-15M/V-25M 39801900-0504

Presentation: 25 x 2,500 dose and 25 x 5,000 dose vials.

NAC No.: 11050094

Merial is now part of Boehringer Ingelheim

Telephone:   888-637-4251
Every effort has been made to ensure the accuracy of the S-706 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2017 North American Compendiums. Updated: 2017-07-10