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This page contains information on Respira-3 for veterinary use.
The information provided typically includes the following:
  • Respira-3 Indications
  • Warnings and cautions for Respira-3
  • Direction and dosage information for Respira-3


This treatment applies to the following species:
Company: Colorado Serum


General Information

This carton includes one bottle of freeze-dried Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3 Vaccine and a second bottle of sterile diluent. When the modified live virus vaccine is rehydrated with diluent, the resulting product may be used to vaccinate healthy calves and non-pregnant cattle. This vaccine is recommended for use as an aid in the prevention of disease caused by infectious bovine rhinotracheitis (IBR) virus, bovine virus diarrhea (BVD) virus, and parainfluenza3 (PI3) virus.

Bovine rhinotracheitis, sometimes referred to as "Red Nose" or "Rhino", is caused by IBR virus which attacts the upper respiratory tract (trachea, mucous membranes, and larynx) of exposed cattle. Salivation, congestion of the nasal mucosa, serous nasal discharge, rapid respiration, coughing, and depression, are some of the clinical signs frequently observed. Temperatures may vary from a little above the normal temperature range of 100.5 - 102.5° F (38-39°C) to as high as 108° F (42°C). High morbidity with low mortality is the usual pattern. The most serious economic factor in the feed lot is the substantial weight loss of affected animals. In dairy cows milk production may be reduced or eliminated as a result of IBR virus infection.

Bovine virus diarrhea appears suddenly in a herd with most of the animals affected. Cattle may develop abnormal temperatures, become depressed, go off feed, have a mucopurulent ocular and nasal discharge and present with a dry non-productive cough. Diarrhea may occur in a majority of these cases. Lameness may also develop in a significant number of the animals.

Parainfluenza3 virus infection may result in coughing, mucopurulent ocular and nasal discharge, difficult respiration, and dehydration. Temperatures may range from a little above normal to as high as 104° F (40° C). Diarrhea usually is not present. Dry scabs may appear on the muzzle.

All three of the above virus infections (IBR, BVD, PI3) are herd diseases that produce high morbidity and low mortality. Substantial weight loss resulting from virus infection may occur in affected animals resulting in an adverse economic impact on the herd. Regular use of Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3 Vaccine is beneficial and considered to be good practice when used according to directions.


Cattle should be vaccinated before or when entering feedlots or areas where dairies are located.

Do not administer to pregnant cows or calves nursing pregnant cows. Do not administer to calves less than 4 weeks of age. Maternal antibodies in young calves may interfere with development of an active immune response. For this reason, calves vaccinated before the age of 6 months should be revaccinated after 6 months of age.

Yearly booster injections are recommended for breeding stock. Be sure that breeding stock are vaccinated on a regular basis when cows are open.

Do not vaccinate within 21 days before slaughter. Needle punctures and tissue damage at the site of injection may result in condemnation of carcasses.

Respira-3 Dosage And Administration

Rehydrate the vaccine just prior to use. Withdraw the entire contents of the accompanying diluent vial with a sterile syringe and needle. Without removing the stopper, transfer the liquid contents to the vial of dried vaccine. Shake the vaccine bottle until the dried material is completely rehydrated. Live virus products contain a stabilizer that may slow rehydration slightly but complete rehydration should occur within a few moments. The vaccine is then ready to use. Use only the diluent furnished with this product for rehydrating the vaccine.

Inject 2 ml of the combined product intramuscularly, preferably in the neck region to avoid areas of prime meat cuts.


1. Store at 2° to 7° C.

2. Use entire contents when first opened.

3. Sterilize needles and syringes by boiling in clean water. Do not use disinfectants or detergents for this purpose.

4. Burn, autoclave or chemically disinfect this container and all unused contents.

5. Contains penicillin and streptomycin as preservatives.

6. Conveniently packaged in 50 dose, and 10 dose sizes.

USDA Code 1171.00

U.S. Vet. License No. 188

COLORADO SERUM COMPANY 4950 York Street, Denver, Colorado 80216, 303-295-7527

Contact us for more information on other Colorado Serum Company products.

Fine Veterinary Biologics since 1923.


CPN: 11010051

4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216-0428
Telephone:   303-295-7527
Order Desk:   800-525-2065
Fax:   303-295-1923
Every effort has been made to ensure the accuracy of the Respira-3 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

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