Skip to Content


This page contains information on Respimune for veterinary use.
The information provided typically includes the following:
  • Respimune Indications
  • Warnings and cautions for Respimune
  • Direction and dosage information for Respimune


This treatment applies to the following species:
Manufacturer: Ceva Biomune

Newcastle Disease Vaccine, B1 Type, Lasota Strain, Live Virus

U.S. Vet. Lic. No.: 368


This vaccine contains Newcastle Disease Virus, B1 Type, Lasota strain, grown in specific pathogen free (SPF) chicken embryos.

Contains gentamicin as a preservative.

Warranty: This vaccine was thoroughly tested before sale and meets the requirements of the U.S. Department of Agriculture.

Respimune Indications

This vaccine is recommended for vaccination of healthy chickens at two weeks of age or older using drinking water, coarse spray or intraocular routes of administration. Revaccination is recommended at 4 weeks and 16 weeks of age. Chickens should be maintained under good environmental conditions and exposure to disease should be reduced as much as possible.

The application of this vaccine to two-week-old chickens will aid in the prevention of Newcastle disease.

Dosage and Administration

For drinking water, coarse spray or intraocular use.

Directions for Drinking Water Application:

1. Do not open or rehydrate the vaccine until ready to vaccinate.

2. Do not use any medications, sanitizers or disinfectants in the drinking water for 48 hours before vaccination and for 24 hours after vaccination.

3. Prior to administration of the vaccine, withhold water from the chickens for 2 hours in warm weather and up to 4 hours in cool weather to stimulate thirst. Be careful in hot weather.

4. Thoroughly rinse water lines or waterers with fresh, clean water. Do not use disinfectants for cleaning water lines or waterers.

5. Rehydrate the vaccine as follows:

Note: As an aid in preserving the vaccine, 30 mL (1 ounce) of rehydrated non-fat powdered milk may be added to each 3.8 liter (1 gallon of clean, cool, non-chlorinated water used for rehydrating and mixing the vaccine.

a. Remove the seal and stopper from the vial containing the freeze-dried vaccine.

b. Carefully pour the milk/water into the vaccine vial until the vial is approximately two-thirds full.

c. Insert the stopper and shake vigorously until all material is rehydrated.

d. Rinse vaccine vial to remove all vaccine and add to the vaccine solution to be administered.

6. Mix rehydrated vaccine with milk/water in accordance with the chart below:

Age of Chickens

Water per 1000 Doses of Vaccine

2 to 3 weeks

6 gallons

22.8 Liters

4 to 7 weeks

12 gallons

45.6 Liters

8 weeks or older

16 gallons

60.8 Liters

7. Distribute the vaccine into the proportioner or among the waterers provided for the chickens. Avoid placing vaccine in direct sunlight.

8. Provide no other drinking water until all the vaccine-water solution has been consumed.

Directions for Coarse Spray Application:

1. Remove the seal and stopper from the vial containing the freeze-dried vaccine.

2. Carefully pour clean, non-chlorinated water into the vaccine vial until the vial is approximately two-thirds full.

3. Insert the stopper and shake vigorously until all material is rehydrated.

4. Pour the rehydrated vaccine into the clean reservoir of the sprayer and dilute further by using 350 mL (or the volume necessary to spray vaccinate 1,000 birds with the sprayer being used) of clean, cool non-chlorinated water for each 1,000 doses of vaccine. For coarse spray administration the droplet size should be greater than or equal to 80 microns.

5. Prior to spraying, reduce air movement in the house by shutting off all fans. Fans should remain on the lowest setting for approximately 10-15 minutes after spraying. Care should be taken so that the chickens are not heat stressed.

6. Spray chickens at the rate of 1,000 per minute while walking slowly through the house. Aim the spray just above the heads of the chickens.

7. Use the sprayer for vaccination purposes only. Clean thoroughly after each use.

8. Avoid direct contact with the vaccine solution. Individual(s) spraying chickens should wear face masks and goggles.

Directions for Intraocular Application:

1. Remove the aluminum seal and rubber stopper from the vial containing the freeze-dried vaccine and pour part of the diluent into the vial.

2. Insert the rubber stopper and shake well until all material is rehydrated. Pour the rehydrated vaccine back into the remaining diluent in the diluent vial and mix.

3. Place the dropper tip on the diluent vial. The vaccine is now ready for intraocular administration as stated below.

4. Hold the bird on its side and allow one drop of the mixed vaccine to fall into the open eye.

5. Hold the bird until the drop of vaccine disappears. Care must be taken to avoid injury to the eye with the dropper tip.

Precaution(s): Store the vaccine at 35°-45°F (2°-7°C).

Do not open and mix the vaccine until ready to begin vaccination.

Use entire contents of vial immediately after mixing.

Burn the container and all unused contents.

This vaccine is not returnable to the manufacturer.

Caution(s): Do not dilute or otherwise extend the dosage.

Vaccinate all chickens on the premises at the same time.

Vaccinate only healthy chickens.

Warning(s): Do not vaccinate within 21 days of slaughter.

Newcastle disease virus may cause redness or inflammation of the eyelids of humans. Avoid contact with eyes, hands and clothing. Wear goggles and mask while mixing and administering vaccine.

February 13, 2002

Presentation: 10 x 1,000 doses, 10 x 2,000 doses, 10 x 2,500 doses, 10 x 5,000 doses, 10 x 10,000 doses and 10 x 25,000 doses.

NAC No.: 11290471

Telephone:   913-894-0230
Fax:   913-894-0236
Every effort has been made to ensure the accuracy of the Respimune information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 Animalytix LLC. Updated: 2018-11-30