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PUREVAX Recombinant Leukemia

This page contains information on PUREVAX Recombinant Leukemia for veterinary use.
The information provided typically includes the following:
  • PUREVAX Recombinant Leukemia Indications
  • Warnings and cautions for PUREVAX Recombinant Leukemia
  • Direction and dosage information for PUREVAX Recombinant Leukemia

Purevax Recombinant Leukemia

This treatment applies to the following species:
Manufacturer: Merial

Feline Leukemia Vaccine

Live Canarypox Vector

For use with the Vet Jet™ transdermal vaccination system


PUREVAX® Recombinant Leukemia contains a non-adjuvanted lyophilized suspension of a recombinant vectored feline leukemia vaccine plus sterile water diluent. A canarypox vector has been modified, using recombinant technology, to produce expression of desired antigens capable of stimulating a protective immune response to feline leukemia. Safety and immunogenicity of this product have been demonstrated by vaccination and challenge tests in susceptible cats.

PUREVAX Recombinant Leukemia Indications

PUREVAX® Recombinant Leukemia is recommended for the vaccination of healthy cats 9 weeks of age or older as an aid in the prevention of disease due to feline leukemia virus.


Aseptically rehydrate the lyophilized vaccine with 0.5 ml of the accompanying sterile water diluent utilizing the Vet Jet™ nozzle, and agitate. Using the Vet Jet™, withdraw 0.25 ml of the reconstituted product. With the Vet Jet™ positioned perpendicular to the leg, administer 0.25 ml (1 dose) transdermally (through the skin) in the lateral thigh. For primary vaccination, cats should receive two 0.25-ml dose vaccinations, three weeks apart. Annual revaccination is recommended. Diagnostic testing for FeLV prior to vaccination is recommended.

Vet Jet™ transdermal Vaccination System

Before you begin, make sure you have each of the following:

1. Attach the adapter to the diluent vial.

Make sure to firmly press the adapter so it sits securely on the vial cap.

2. If not already assembled, insert the nozzle plunger into the nozzle.

Attach the nozzle to the adapter, with the attached diluent vial, by inserting the nozzle orifice into the luer lock of the adapter.

Push the nozzle into the adapter to ensure a tight fit.

3. The nozzle contains a "STOP" to prevent accidental withdrawal of the plunger. The "STOP" is indicated by a ring that encircles the nozzle 1/4" above the base flange.

Filling the nozzle to the "STOP", yields 0.5 ml of diluent.

(For "STOP" location, see Step 4.)

4. Invert the diluent vial/adapter/nozzle assembly.

Withdraw the diluent into the nozzle, filling the nozzle to the "STOP" ring just above the base flange with 0.5 mL of diluent.

Be sure to remove air bubbles by gently tapping the nozzle and injecting them back into the vial.

5. Remove the diluent vial from the adapter/nozzle assembly.

Be sure to properly dispose of the diluent vial and unused contents in accordance with appropriate medical procedures.

Contents of the diluent vial equal a single dose.

6. Place the lyophilized vaccine vial on a stable surface.

Attach the adapter/nozzle assembly (filled with diluent) by firmly pressing the adapter onto the vial cap.

Be sure the adapter/nozzle assembly is securely attached to the vaccine vial.

7. Inject the diluent into the vaccine vial.

8. To reconstitute the lyophilized vaccine product with the diluent, gently shake the vial.

Make sure that the adapter/nozzle assembly is still attached.

9. For flat sided nozzles: Make sure that the flat sides of the nozzle plunger are aligned with the flat sides of the nozzle flange.

For round sided nozzles, no alignment is necessary.

The nozzle plunger base contains a slot that slips onto the stainless steel plunger located in the notch at the end of the injector.

10. Slide the adapter/nozzle assembly (with reconstituted vaccine vial attached) into the notch at the nozzle end of the injector.

Be sure that the nozzle slides in easily. If it is difficult to slide into the notch, please be sure that the flat sides of the nozzle plunger are aligned with the flat sides of the nozzle flange. If the nozzle is not fully inserted it may be difficult to turn the locking collar (Step 11) or turn the dose knob when dosing the injector (Step 12).

11. To lock the vaccine vial/adapter/nozzle assembly into place, turn the locking collar of the injector clockwise until it stops.

If the locking collar is difficult to turn, make sure the nozzle is fully inserted into the injector.

12. Turn the dose knob clockwise until the blue injector button pops out.

At This Point The Injector Is Activated.

Important Note

Once the injector is activated, do not touch the blue activator button until you are ready to administer vaccine. Do not attempt to remove a nozzle from the injector once it is activated.

13. With injector activated and painted up (vaccine vial inverted), turn the dose knob counterclockwise to withdraw 0.25 ml of the vaccine.

Vaccine will enter into the nozzle as the dial is turned.

Contents of the vaccine vial equal a single dose.

a. If the dose knob is difficult to turn, make sure the node is fully inserted into the injector.

b. Remove air bubbles by gently tapping the nozzle. Make sure the nozzle contains vaccine and that large air bubbles are removed.

14. Remove the adapter and vial from the nozzle. The nozzle with vaccine will remain attached to the injector.

Be sure to remove both the vaccine vial AND the adapter. Only the nozzle should remain attached to the injector.

Be sure to properly dispose of the vaccine vial and unused contents in accordance with label directions and appropriate medical procedures.

15. Finely hold the injector with nozzle perpendicular to the injection site. Press firmly against the skin and press the blue activator button.

Hold the injector firmly in place until the vaccine has been delivered. (count 1 second)

Use aseptic technique when administering vaccines.

Use the injection technique and injection location as instructed on the vaccine label.

Use appropriate animal restraint techniques standard in veterinary practice for vaccination.

16. To remove the nozzle from the injector, turn the locking collar counterclockwise.

Discard the nozzle in accordance with appropriate medical procedures.

Helpful Hints

If Diluent Will Not Draw Down

Remove nozzle from vial adapter and reconnect again.

Make sure nozzle is firmly connected to the vial adapter.

If you still experience difficulties, replace nozzle.

If Vaccine Will Not Draw Down

Follow the steps above.

Make sure the nozzle is properly seated in the injector (see Step 10).

If A Very Loud Noise Occurs When You Press The Blue Activator Button, You May Have Dry Fired The Injector - This Means There Was Large Amount Of Air Or No Fluid In The Nozzle.

make Sure You Have Fluid In The Nozzle By Drawing Down Dose Slowly.

change Nozzle And Vial Adapter When Appropriate.

if You Need To Deactivate The Injector

Make sure the dose knob is turned fully to the clockwise position (dose measurement scale on "0" ml).

PRESS AND HOLD the blue activator button while turning the dose knob counterclockwise at least 1 full turn.

The injector is now deactivated.


Always be certain that the nozzle is filled with liquid before activating the injector.

Do Not Dry-fire The Injector.

Do Not Fire The Injector Without Fluid In The Nozzle. This May Result In Damage To The Injector Or Breakage Of Nozzle/adapter Assembly.

use The Injector As Specified. Do Not Eject Vaccine Into The Air Or Onto An Animal's Haircoat. Administer Vaccines At The Appropriate Site Specified For The Product.

only Use This Injector To Administer Vaccines That Are Formulated For Administration With The Vet Jet™. Failure Of Proper Administration Can Result In Failure To Protect The Patient Against The Target Disease(s).

when Administering The Vaccine, Make Sure The Injector Is Held Firmly In Contact With The Injection Site Until The Vaccine Dose Has Been Delivered.

when The Injector Is Activated, Use Caution To Avoid Pressing The Blue Activator Button Until You Are Ready To Administer The Vaccine.

do Not Point The Injector Toward People Or Animals.

do Not Attempt To Remove The Nozzle From An Activated Injector. See Deactivation Instructions.

do Not Immerse The Injector In Water Or Other Solutions.

turning The Dose Knob More Than One Turn In The counterclockwise Direction Past The 0.5 Ml Dose Mark, Will Result In Removal Of The Dose Knob From The Injector. The Dose Knob Can Be Easily Replaced By Reinserting And Turning In A Clockwise Direction.

the Injector Contains A Feature That Is Designed To Be The First Component To Fail At The Termination Of Active Life. When This Failure Occurs, The Injector Will Lack Or Be Unusable. If This Is Observed Or Other Malfunctions Occur, Call Merial Technical Services At 1-888-merial1, Option 3 For Assistance.

warning: Must Be Used Only For Cats. Not For Use In Humans.

PUREVAX Recombinant Leukemia Caution: Federal (usa) Law Restricts This Injector To Use By Or On The Order Of A Licensed Veterinarian.


Store at 2-7°C (35-45°F). Do not use chemicals to sterilize transfer apparatuses or the Vet Jet™. Burn container and all unused contents. Contains gentamicin as a preservative. It is generally recommended to avoid vaccination of pregnant cats. In rare instances, administration of vaccines may cause lethargy, fever, and inflammatory or hypersensitivity types of reactions. Treatment may include antihistamines, anti-inflammatories, and/or epinephrine.


For veterinary use only.

PUREVAX is a registered trademark of MERIAL

Manufactured By MERIAL, INC., Athens, GA 30601 USA

U.S. Vet. Lic. No. 298

1-888-Merial-1 (1-888-637-4251)

©2005 Merial. All rights reserved.

VET JET™ is a trademark of Merial.

Manufactured under the following U.S. patents: 5,782,802, 4966581, and 5893397.

For more information, please call 1-888-637-4251.

Manufactured by BIOJECT INC., 20245 5W 95th Ave., Tualatin, OR 97062 U.S.A.

Marketed by MERIAL LIMITED, 3239 Satellite Blvd., Duluth, GA 30096 U.S.A.

1050-1866-05 Rev 08/2006



Prod. No.


25 Doses

25 x 1 Dose, Lyophilized

25 x 1 mL, Sterile Water



Nac No.


Telephone:   888-637-4251
Every effort has been made to ensure the accuracy of the PUREVAX Recombinant Leukemia information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-03-29