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Pre-Breed 8

This page contains information on Pre-Breed 8 for veterinary use.
The information provided typically includes the following:
  • Pre-Breed 8 Indications
  • Warnings and cautions for Pre-Breed 8
  • Direction and dosage information for Pre-Breed 8

Pre-Breed 8

This treatment applies to the following species:
Company: Colorado Serum

Modified Live Virus


General Information

This carton includes one bottle of dried Bovine Rhinotracheitis - Virus Diarrhea - Parainfluenza3 Vaccine and a second bottle of liquid inactivated Leptospira Canicola - Grippotyphosa - Hardjo - Icterohaemorrhagiae - Pomona Bacterin (Lepto - 5). When combined as directed the resulting product may be used to vaccinate healthy calves and non-pregnant cattle. For use as an aid in the prevention of infectious bovine rhinotracheitis, virus diarrhea, parainfluenza3 and leptospirosis caused by the serotypes included in the bacterin. Concentration of the bacterin fraction is by improved methods that retain the original antigens to assure full immunizing effect.

Bovine rhinotracheitis, sometimes referred to as "Red Nose" or "Rhino", is caused by IBR virus which attacks the upper respiratory tract (trachea, mucous membranes, and larynx) of exposed cattle. Salivation, congestion of the nasal mucosa, serous nasal discharge, rapid respiration, coughing, and depression, are some of the clinical signs frequently observed. Temperatures may vary from a little above the normal temperature range of 100.5 - 102.5° F (38-39°C) to as high as 108° F (42°C). High morbidity with low mortality is the usual pattern. The most serious economic factor in the feed lot is the substantial weight loss of affected animals. In dairy cows milk production may be reduced or eliminated as a result of IBR virus infection.

Bovine virus diarrhea appears suddenly in a herd with most of the animals affected. Cattle may develop abnormal temperatures, become depressed, go off feed, have a mucopurulent ocular and nasal discharge with a dry non-productive cough. Diarrhea may occur in a majority of these cases. Lameness may also develop in a significant number of the animals.

Parainfluenza3 virus infection may result in coughing, mucopurulent ocular and nasal discharge, difficult respiration, and dehydration. Temperatures may range from a little above normal to as high as 104° F (40° C). Diarrhea usually is not present. Dry scabs may appear on the muzzle.

Leptospirosis symptoms most frequently noted are rapid rise in temperature, depression and loss of appetite. Urine may become coffee-colored or streaked with blood. Animals become anemic. Milk production drops or ceases, Abortions may occur at any stage of pregnancy but usually in the last trimester. Full term calves may be dead or weak. Death losses can reach serious proportions in calves a year old or younger.


Cattle should be vaccinated before or when entering feedlots or areas where dairies are located.

Do not administer to pregnant cows or calves nursing pregnant cows. Do not administer to calves less than 4 weeks of age. Maternal antibodies in young calves may interfere with development of an active immune response. For this reason, calves vaccinated before the age of 6 months should be revaccinated after 6 months of age.

Yearly booster injections are recommended for breeding stock. Be sure that breeding stock are vaccinated on a regular basis when cows are open.

Do not vaccinate within 21 days before slaughter. Needle punctures and tissue damage at the site of injection may result in condemnation of carcasses.


Anaphylactoid reaction may occur following administration of products of this nature. If noted, administer adrenalin or equivalent.

Pre-Breed 8 Dosage And Administration

Rehydrate the vaccine just prior to use. To rehydrate the vaccine, withdraw the entire contents of the accompanying Lepto-5 Bacterin vial with a sterile syringe and needle, without removing the stopper, and transfer it to the vial of dried vaccine. Shake the vaccine bottle until dried material is completely rehydrated. Live virus products contain a stabilizer that may slow rehydration slightly but complete liquefaction will take place within a few moments. The vaccine is then ready to use.

Inject 2 ml of the combined product intramuscularly, preferably in the neck region to avoid areas of prime meat cuts.


1. Store at 2° to 7° C.

2. Use entire contents when first opened.

3. Sterilize needles and syringes by boiling in clean water. Do not use disinfectants or detergents for this purpose.

4. Burn, autoclave or chemically disinfect this container and all unused contents.

5. Contains thimerosal, penicillin and streptomycin as preservatives.

6. Conveniently packaged in 50 dose, and 10 dose sizes.

USDA Code 4439.00

U.S. Vet. License No. 188

COLORADO SERUM COMPANY, 4950 York Street, Denver, Colorado 80216


Contact us for more information on other Colorado Serum Company products.

Fine Veterinary Biologics since 1923.


CPN: 11010380

4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216-0428
Telephone:   303-295-7527
Order Desk:   800-525-2065
Fax:   303-295-1923
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