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Pre-Breed 6

This page contains information on Pre-Breed 6 for veterinary use.
The information provided typically includes the following:
  • Pre-Breed 6 Indications
  • Warnings and cautions for Pre-Breed 6
  • Direction and dosage information for Pre-Breed 6

Pre-Breed 6

This treatment applies to the following species:
Company: Colorado Serum


Modified Live Virus


General Information

This carton includes one bottle of dried Bovine Rhinotracheitis Vaccine and a second bottle of liquid inactivated Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (Lepto 5). When combined as directed the resulting single product is recommended for the vaccination of healthy cattle and calves against bovine rhinotracheitis infection and leptospirosis caused by the serotypes included in the bacterin. Concentration of the bacterin fraction is by improved methods that retain the original antigens to assure full immunizing effect.

Bovine Rhinotracheitis is normally sudden and mild in nature. Salivation, congestion of the nasal mucosa, serous nasal discharge, rapid respiration, coughing, and depression are some of the symptoms frequently observed. Temperatures may vary from slightly above normal to as high as 108° F. (42° C.).

Leptospirosis symptoms most frequently noted are rapid rise in temperature, depression and loss of appetite. Urine may become coffee-colored or streaked with blood. Animals become anemic. Milk production drops or ceases, Abortions may occur at any stage of pregnancy but usually in the last one-third. Full term calves may be dead or weak. Death losses can reach serious proportions in calves a year old or younger.


When To Vaccinate

Cattle should be vaccinated before or at the time of admission to feed lots or dairy areas. Yearly booster injections are recommended for breeding stock and dairy cattle. Maternal antibodies in young calves may interfere with development of an active immunity. If emergency conditions require vaccination these calves should be revaccinated one month after weaning.

Do not use in pregnant cows or in calves nursing pregnant cows. Be sure that breeding stock is immunized on a regular basis when cows are open.

Do not vaccinate within 21 days before slaughter. Needle punctures and tissue damage at the site of injection may result in condemnation of carcasses.

Pre-Breed 6 Dosage And Administration

Rehydrate the vaccine just prior to use. Withdraw and transfer to the bottle of dried vaccine all of the contents of the bottle of Lepto-5 Bacteria which is supplied as a component part of this combination package. Do this without removing the stoppers from either bottle using a sterile syringe and needle. The intermix should be thoroughly shaken to rehydrate the vaccine and to equally distribute all antigenic substances throughout the combination. The product is then ready to use.

Recommended dose is 2 ml. to be administered immediately after rehydrating. Injection should be intramuscular, preferably in the neck region to avoid areas of prime meat cuts.

Anaphylaxis (shock) may sometimes follow the use of products of this nature. Epinephrine or equivalent should be available for immediate use in these instances. Artificial respiration is also helpful.


1. Contains permitted levels of penicillin and streptomycin.

2. Store in dark at 2° to 7° C.

3. Sterilize needles and syringes by boiling in clean water. Do not use chemical disinfectants or detergents for this purpose.

4. Use entire contents when bottle is first opened.

5. Burn this container and all unused contents.

6. Conveniently packaged in 50 Dose and 10 Dose sizes.

Produced Under U.S. Veterinary License No. 188 by


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Fine Veterinary Biologicals Since 1923


CPN: 11010370

4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216-0428
Telephone:   303-295-7527
Order Desk:   800-525-2065
Fax:   303-295-1923
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