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Penpro (Canada)

This page contains information on Penpro for veterinary use.
The information provided typically includes the following:
  • Penpro Indications
  • Warnings and cautions for Penpro
  • Direction and dosage information for Penpro


This treatment applies to the following species:
Company: Vetoquinol

DIN 00544051

Veterinary Use Only

Penicillin G Procaine

Sterile Aqueous Suspension, Mfr

300,000 I.U./mL


Penicillin G Procaine is an antibacterial agent effective against a wide variety of pathogenic organisms. It is the water-insoluble salt of benzyl penicillin containing one molecule of penicillin G combined with one molecule of procaine base. PENPRO, aqueous suspension, is a sterile free-flowing product prepared from penicillin G procaine crystalline. Each mL contains 300,000 I.U. of penicillin G.

Penpro Indications

As an aid in the treatment of the following infections caused by bacteria susceptible to penicillin.

Cattle: Bacterial pneumonia; calf diphtheria; footrot; metritis; wound infections.

Sheep: Bacterial pneumonia; metritis; wound infections.

Swine: Bacterial pneumonia; erysipelas; wound infections.

Horses: Bacterial pneumonia; metritis; strangles; wound infections.


Shake well before using. The intramuscular route only must be used for the administration of PENPRO, aqueous suspension.

1) Cattle and Sheep: 21,000 IU/kg (7 mL/100 kg or 0.7 mL/10 kg) of body weight intramuscularly once daily until 2 days after clinical signs disappear. Do not exceed 5 days of treatment. Do not exceed 15 mL per injection site in cattle and 10 mL per injection site in sheep.

2) Swine: 15,000 IU/kg (1 mL/20 kg) of body weight intramuscularly once daily until 2 days after clinical signs disappear. Do not exceed 5 days of treatment. Do not exceed 10 mL per injection site.

3) Horses: 21,000 IU/kg (7 mL/100 kg) of body weight intramuscularly twice daily (at 12 hours intervals) until 2 days after clinical signs disappear or, in the case of respiratory infections, until 5 days after clinical signs disappear. Do not exceed 15 mL per injection site. Rotate injection sites for succeeding doses.

Note: If animals do not respond within 48 hours of administration of the first dose, consult a veterinarian. An alternative antibacterial therapy should be considered.


Occasional sensitivity (anaphylaxis) to penicillin has been known to occur (acute respiratory distress, mouth breathing, recumbency). In such cases, administer epinephrine immediately to prevent death.

In pigs, the administration of this product may occasionally cause a fever, vomiting, shivering, listlessness, incoordination and possibly, death.

In pregnant sows and gilts, it may result in abortions.

In horses, Penicillin G Procaine is occasionally associated with excitement and may cause pain at the site of injection. Repeated use of the same injection site may intensify these side effects.


To avoid illegal residues, do not inject subcutaneously.

Cattle and Sheep: Treated animals must not be slaughtered for use in food for at least 10 days after the latest treatment with this drug. Milk taken from treated animals during treatment and within 96 hours after the latest treatment must not be used as food.

To avoid illegal residues in milk: Do not use in dairy animals with clinical or subclinical mastitis and do not exceed the recommended dosage. The use of on-farm tests for detecting subclinical mastitis prior to treatment (C.M.T. or other tests) and/or for detecting residues prior to marketing milk from treated animals is recommended.

Swine: Treated animals must not be slaughtered for use in food for at least 8 days after the latest treatment with this drug.

Horses: This drug is not to be administered to horses that are to be slaughtered for use in food.


Shake well before using. Store between 2°C and 8°C.


PENPRO, aqueous suspension is available in 100 mL (code 11804), 250 mL (code 11775) and 500 mL (code 11805) vials.

Vetoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada, J5T 3S5





100 mL


216997C03, 017491L06

250 mL


216996C03, 018491L07

500 mL


216995C03, 019491L07

NAC No.: 1234257.3

Commercial Division

Telephone:   450-586-2252
Order Desk:   800-363-1700
Fax:   450-586-4649
Every effort has been made to ensure the accuracy of the Penpro information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2019 Animalytix LLC. Updated: 2019-09-30