OxytocinThis page contains information on Oxytocin for veterinary use.
The information provided typically includes the following:
- Oxytocin Indications
- Warnings and cautions for Oxytocin
- Direction and dosage information for Oxytocin
OxytocinThis treatment applies to the following species:
Purified Oxytocic Principle (20 USP Units per mL)
Sterile Aqueous Solution
FOR ANIMAL USE ONLY
KEEP OUT OF REACH OF CHILDREN
For use in inducing rhythmic contractions of the smooth musculature of the uterus and/or milk letdown.
Oxytocin injection is a sterile aqueous solution of highly purified oxytocic principle derived by synthesis or obtained from the posterior lobe of the pituitary gland of healthy domestic animals used for food by humans. Oxytocin injection contains 20 USP Units of oxytocin and less than 0.4 units of presser activity per mL. Each mL of sterile solution also contains 0.9% w/v sodium chloride, 0.5% w/v chlorobutanol (as a preservative), with water for injection q.s. and pH adjusted to 3.0 to 5.0 with acetic acid.
ACTIONS: Oxytocin acts directly on the smooth musculature of the uterus in all species to induce rhythmic contractions, although in some species the uterine cervix does not respond to oxytocin. The responsiveness of the uterine musculature to oxytocin varies greatly with the stage of the reproductive cycle. During the early phases of pregnancy the uterus is relatively insensitive to the effects of oxytocin, while in the late phases the sensitivity is markedly increased. Most authorities attribute this varying response to the varying levels of estrogen and progesterone during the course of pregnancy. Oxytocin also has been shown to exert a milk ejecting effect, occasionally referred to as the galactogogic effect. The actual mechanism by which oxytocin stimulates the release of milk from the mammary glands is not known with certainty, but oxytocin is presumed to act on certain smooth muscle elements in the gland.
Because of the specific action of oxytocin upon the uterine musculature, it is recommended as an aid in the management of the following conditions:
1) To precipitate labor.
2) To accelerate normal parturition.
3) Postpartum evacuation of uterine debris.
4) Postoperative contraction of the uterus following a cesarean section and control of uterine hemorrhage.
Oxytocin will contract the smooth muscle cells of the mammary gland to induce milk let-down if the udder is in a proper physiological state.
CONTRAINDICATION: Do not use in dystocia due to abnormal presentation of the fetus until correction is accomplished.
PrecautionsOxytocin is a potent preparation, accordingly, it should be administered with due caution. For prepartum usage full dilation of the cervix should be accomplished either naturally or through the administration of estrogen prior to oxytocin therapy.
Dosage and Administration
Obstetrical Use: Inject aseptically by the intravenous, intramuscular or subcutaneous route as follows:
1.5 to 2.5 mL
30 to 50 USP Units
100 USP Units
These dosages are recommended, and may be repeated as indicated.
Inject aseptically by the intravenous, intramuscular or subcutaneous route.
0.5 to 1.0 mL
10 to 20 USP Units
0.25 to 1.0 mL
5 to 20 USP Units
These dosages are recommended and may be repeated as necessary.
Note: Oxytocin will not induce milk let-down unless the udder is in the proper physiological state.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
100 mL multiple dose vials.
Store at controlled room temperature.
Do Not Freeze.
ANADA #200-328, Approved by FDA
Restricted Drug (California) - Use Only as Directed
Manufactured by Bimeda-MTC Animal Health Inc., Cambridge, Canada
Manufactured for Agri Laboratories, Ltd., St. Joseph, MO 64503
® Registered Trademark of Agri Laboratories, Ltd.
20927 STATE ROUTE K, P.O. BOX 3103 (64503), ST. JOSEPH, MO, 64505
|Every effort has been made to ensure the accuracy of the Oxytocin information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.|
Copyright © 2018 North American Compendiums. Updated: 2018-09-03