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OraStrip QuickCheck Canine

This page contains information on OraStrip QuickCheck Canine for veterinary use.
The information provided typically includes the following:
  • OraStrip QuickCheck Canine Indications
  • Warnings and cautions for OraStrip QuickCheck Canine
  • Direction and dosage information for OraStrip QuickCheck Canine

OraStrip QuickCheck Canine

This treatment applies to the following species:
Manufacturer: PDx BioTech

Product Information

OraStrip QuickCheck Canine is a point-of-care diagnostic test for the detection and monitoring of active periodontal disease. It measures the presence and severity of periodontal infection in dogs. It should be used only as directed. Regular use of OraStrip QuickCheck Canine as part of routine patient work-up has been shown to detect and monitor underlying active periodontal disease typically underestimated by the visual awake examination of the gums. OraStrip may be routinely incorporated into wellness exams in conjunction with annual diagnostic tests such as fecal, heartworm and blood work.

Intended Use

● For routine use by veterinary professionals in the awake dog for the detection and monitoring of active periodontal disease. Appropriate for use in dogs scheduled to undergo examination under anesthesia. In these dogs, the OraStrip test is intended for use prior or subsequent to premedication, but before administration of any anticholinergic or anesthetic agents that may cause dry mouth.

● For use in conjunction with routine visual awake exams, as active periodontal disease is typically underestimated by the visual awake exam but is detected through use of the OraStrip test.

● Should not be used with overtly bleeding gums, as blood interferes with the ability to read and interpret the test result.

(1) In Dogs without Documented History of Periodontal Disease

Use in conjunction with routine oral examinations in the awake patient during wellness exams, at least twice a year.

● For patients with an OraStrip test result of 1 and higher, further dental diagnostic evaluation and/or therapeutic plans may be recommended and discussed with the client.

● Discuss wellness, preventive dental care and daily oral health maintenance with the client to ensure optimal home care. Retest patient within 3 months.

(2) In Dogs with Documented History of Periodontal Disease

Use every 3 to 6 months during follow-up evaluations to monitor active periodontal disease.

● Use in conjunction with the oral examination in the awake animal.

● If the patient is scheduled for a dental or other procedure under general anesthesia, the OraStrip test should be used prior to the administration of general anesthetic.

● OraStrip test result obtained during follow-up evaluation should be compared to previous OraStrip test result to determine the recurrence of the infection and effectiveness of treatment plan, evaluate client compliance and revise treatment plan recommendations as needed. Retest and monitor every 3 months in patients with gingivitis and periodontitis and every month in patients with advanced periodontal disease until the disease is controlled.

For further diagnostic recommendations, see AAHA* Dental Care Guidelines, J Am Anim Hosp Assoc 41: 1-7 (2013). Note: AAHA recommends dental evaluations for dogs as young as five months of age and points out that, during an oral examination on a conscious patient, “in many instances...the examiner will underestimate the conditions present because it is impossible to visualize all oral structures when the patient is awake.” In addition the AAHA Guidelines state:

● “Evaluate disease status, such as periodontal disease, on the conscious patient with products that allow an assessment of periodontal health without placing the patient under anesthesia.”

● “A diagnostic test strip for the measurement of dissolved thiol levels can be used as an exam room indicator of gingival health and periodontal status.”

*AAHA is a registered trademark of the American Animal Hospital Association.

Instructions for Use

Note: When collecting oral fluid sample from dogs, typical protective equipment routinely employed in veterinary practice should be worn.

Remove the protective pouch from the comparator card to reveal the color chart. Then remove the OraStrip test from its protective pouch, taking care not to touch the small pad located atop the strip.

Sample Collection

In general, particulate matter and blood will interfere with proper interpretation of the result. It is important to glide the pad gently along the gingival margin, where the teeth meet the gums, so as not to induce bleeding. When obtaining a sample, avoid applying excessive pressure, which could dislodge plaque and obscure the test result but enough pressure to collect fluid on the test pad.

● Place your index finger behind the non-pad side of the OraStrip test.

● Lift the dog’s upper lip.

● Gently glide the pad along the entire maxillary facial (buccal and labial) gingival margin, where the gums meet the teeth.

- This procedure draws a mixed gingival crevicular / salivary fluid into the pad and should take no more than 5-10 seconds.

● Remove the test strip from the dog’s mouth.

● Wait 10 seconds and read the result.





Reading the Result

● Hold the test strip near the numbered colors shown on the color chart.

● Determine and record the number of the color closest to the color observed on the pad.

● If the color on the pad is not uniform, use the most intense color seen on the pad. A non-uniform color is still a valid result. This can occur if the gingival tissues are very dry or if periodontal infection is localized or unevenly distributed throughout the mouth.

● Read the test result within 5 minutes after sample collection.

Interpreting the Result

The numerical result recorded is interpreted as follows:

● 0 - Indicates a healthy periodontal status not associated with periodontal infection. For dogs with a history of periodontal disease, this value reflects controlled management of active periodontal disease, and continuation of maintenance treatment modalities may be warranted. Your Dental Care Plan should be based upon patient history and may include: dental prophylaxis, professional dental cleanings, periodontal therapy, home care and an anesthetized dental evaluation, including radiographs.

● 1 or above - Indicates active periodontal disease beneath the gumline. Your Dental Care Plan should be based upon patient history and may include: dental prophylaxis, professional dental cleanings, periodontal therapy, home care and an anesthetized dental evaluation, including radiographs.

Turn the card over and record the test result on the OraStrip QuickCheck Report Card, an integral component to increase client compliance. Record the date, patient name and OraStrip test result and prescribe your Dental Care Plan to the client. Hand the Report Card to every client as their dental care prescription as a reminder to comply with the Dental Care Plan. Discuss with your client the importance of following your Dental Care Plan between visits and returning for a follow-up appointment. The Report Card also includes further information on periodontal disease and the date of the next follow-up appointment.

Interfering Substances

Highly pigmented substances such as blood will interfere with the ability to read and interpret the result. Therefore, the sample should be gently collected in such a way that no blood contacts the pad of the test strip. Similarly, avoid contacting heavy plaque deposits during sample collection; these also can obscure the test result.

Principle of Operation

Upon contact with a sample of oral fluid (obtained from the gingival margin), OraStrip QuickCheck Canine provides an objective visual signal related to the concentration of thiols (also called mercaptans or sulfhydryl compounds) present in the sample. Thiols are produced by microorganisms closely associated with active periodontal disease. When left untreated, active periodontal disease can lead to progressive tissue destruction and loss of tooth attachment. In addition, periodontal disease is associated with cardiovascular, renal, and hepatic diseases and other serious conditions adversely impacting quality of life.

Clinical Background

OraStrip QuickCheck Canine directly measures the concentration of thiols in canine oral fluid from the gingival margin. Thiols measured by OraStrip QuickCheck Canine provide a direct indication of the severity of active periodontal infection. Regular use of OraStrip QuickCheck Canine as part of routine patient work-up has been shown to detect and monitor underlying active periodontal disease. Clinical data have associated low strip values with healthy periodontal status and the absence of periodontal infection.1 In dogs, active periodontal disease involves infection of the gums by anaerobic microorganisms including those from the genera Porphyromonas (such as P. gingivalis) and Treponema (such as T. denticola).2 When such microbes are present within subgingival biofilms, they are known to produce large quantities of metabolic products called thiols3 that can disrupt gum tissue and destroy healthy bone by inducing bone loss. Thiols disrupt epithelial integrity;4 cause death of gingival epithelial cells through apoptosis;5 and induce bone loss through stimulation of osteoclasts6 and inhibition of osteoblasts.7 In dogs, periodontal disease is associated with adverse systemic outcomes,8 as well as with hepatic, renal and cardiovascular lesions.9

Literature Cited

1 Manfra Marretta S, Leesman M, Burgess-Cassler A, McClure GD Jr, Buelow M, Finn M (2012) Can Vet J. 53:1260-1265; Queck KE et al (manuscript in preparation).

2 Isogai H, Kosako Y, Benno Y, Isogai E (1999). Zentralbl Veterinarmed B. 46(7):467-73; Hardham J, Dreier K, Wong J, Sfintescu C, Evans RT (2005). Vet Microbiol. 106(1-2):119-28; Nordhoff M et al (2008). Veterinary Microbiol. 127:334-342.

3 Yoshida A, Yoshimura M, Ohara N, Yoshimura S, Nagashima S, Takehara T, Nakayama K (2009). J Periodontol. 80(11):1845-51; Chen W, Kajiya M, Giro G, Ouhara K, Mackler HE, Mawardi H, Boisvert H, Duncan MJ, Sato K, Kawai T (2010). Biochem Biophys Res Commun. 391(1):645-50.

4 Ng W, Tonzetich J (1984). J Dent Res. 63(7):994-7; Johnson P, Yaegaki K, Tonzetich J (1996). J Periodontal Res. 31(5):323-9.

5 Calenic B, Yaegaki K, Murata T, Imai T, Aoyama I, Sato T, Ii H (2010). J Periodontal Res. 45(1):31-7.

6 Irie K, Ekuni D, Yamamoto T, Morita M, Yaegaki K, Ii H, Imai T (2009). Arch Oral Biol. 54(8):723-9; Ii H, Imai T, Yaegaki K, Irie K, Ekuni D, Morita M (2010). J Periodontol. 81(11):1691-7.

7 Imai T, Ii H, Yaegaki K, Murata T, Sato T, Kamoda T (2009). J Periodontol. 80(12):2028-34.

8 Rawlinson JE, Goldstein RE, Reiter AM, Attwater DZ, Harvey CE (2011). J Am Vet Med Assoc. 238(5):601-9.

9 DeBowes LJ, Mosier D, Logan E, Harvey CE, Lowry S, Richardson DC (1996). J Vet Dent. 13(2):57-60.

PDx BioTech, Lexington, KY 40508

855-OraStrip (855-672-7874)

PN 101-0014, rev D

Presentation: Box of 24 test strips.

NAC No.: 1728000.0

Telephone:   859-388-9445
Toll-Free:   855-OraStrip (855-672-7874)
Fax:   859-519-5459
Every effort has been made to ensure the accuracy of the OraStrip QuickCheck Canine information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-09-02