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This page contains information on Lepto-5 for veterinary use.
The information provided typically includes the following:
  • Lepto-5 Indications
  • Warnings and cautions for Lepto-5
  • Direction and dosage information for Lepto-5


This treatment applies to the following species:
Company: Colorado Serum

Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin

U.S. Vet. Lic. No.: 188

Contents: Inactivating whole cultures of L. canicola, L. grippotyphosa, L. hardjo, L. icterohaemorrhagiae, and L. pomona, aluminum hydroxide adsorbed.

Lepto-5 Indications

For vaccination of healthy cattle and swine in areas where the serotypes named are known to be prevalent.

Dosage and Administration

Shake well. Aseptically inject 2.0 mL subcutaneously or intramuscularly. For swine, a second dose should be administered 2-4 weeks later. Annual re-vaccination is recommended for both species.

When to Vaccinate: Vaccination of both cattle and swine at least 3 weeks prior to breeding is recommended (1) on premises having a history of leptospirosis (2) when the disease exists in the area, and (3) when animals may be exposed to carriers of the micro-organisms.

Precaution(s): Store in dark at 2° to 7°C.

Use entire contents when bottle is first opened.

Caution(s): Anaphylactoid reaction sometimes follows administration of products of this nature. If noted, administer adrenalin or equivalent.

Warning(s): Do not vaccinate within 21 days before slaughter.

Discussion: Leptospirosis is one of the more serious diseases of cattle and swine. It is directly transmitted by contact with sick animals, through urine and mucous of the eyes, nose, and mouth; indirectly through water tanks and streams carrying live micro-organisms after being shed by infected animals. Clinical signs of the disease vary greatly from mild to severe and because of this it is difficult to list common symptoms. The following, however, have been reported as having been observed.

In calves, symptoms may include a rapid rise in temperature with depression and loss of appetite. The urine may become coffee-colored and sometimes streaked with blood. Animals may be anemic. Death losses can, in some instances, reach substantial proportions in calves under one year of age.

In older cattle the disease usually follows a milder course, with animals showing only a loss of appetite and depression for several days until death losses or abortions occur. L. hardjo infection, for instance, is clinically insignificant but is increasing in the number of isolations.

In dairy cattle the disease may result in a sharp reduction in milk production and this may be the first indication of infection. Udder secretions may be of a thick, yellowish nature. Frequently, the symptoms may be mistaken for common mastitis but the udder is not generally inflamed. In swine there are often no signs of infection until abortions occur. Sows generally abort two to four weeks before delivery date and the rate may be high. In some instances, sows may carry to full term but litters may contain dead and/or weak pigs.

When to Vaccinate: Vaccination of both cattle and swine at least 3 weeks prior to breeding is recommended (1) on premises having a history of leptospirosis (2) when the disease exists in the area, and (3) when animals may have been exposed to carriers of the micro-organisms.

Hogs being raised for market should also be vaccinated if contact with the disease is likely. These animals should not thereafter be offered for slaughter until the full withdrawal time, as shown above, has been observed.

Best results are to be expected when the bacterin is administered prior to exposure of the animals. However, if infection has appeared in the herd, isolate the sick animals and vaccinate all those that are apparently unaffected. Some vaccinates may thereafter develop symptoms because immune response from administration of bacterin is not immediate. Vaccination of infected herds is suggested as Leptospira bacterins have been found to be of help in stopping spread of disease and bringing outbreaks under control.

Vaccination is recommended also for healthy herds suspected of having been exposed to leptospirosis and for herds into which replacement stock is periodically introduced. Such replacement stock should be vaccinated as well and hold separately until protective immunity is established. Isolation of new stock should be a rigid practice in herd management not only for aid in preventing leptospirosis but other diseases as well.

Revaccinate animals retained for breeding and those held beyond a normal marketing period, on an annual basis. In heavily contaminated areas semi-annual vaccination should be practiced. Occasionally, it may be necessary to vaccinate very young calves. If so, these should be revaccinated at 3-4 months of age.

Presentation: 10 dose (20 mL) and 50 dose (100 mL) vials.

CPN: 11010252

4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216-0428
Telephone:   303-295-7527
Order Desk:   800-525-2065
Fax:   303-295-1923
Every effort has been made to ensure the accuracy of the Lepto-5 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-10-21