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First Defense Tri-Shield

This page contains information on First Defense Tri-Shield for veterinary use.
The information provided typically includes the following:
  • First Defense Tri-Shield Indications
  • Warnings and cautions for First Defense Tri-Shield
  • Direction and dosage information for First Defense Tri-Shield

First Defense Tri-Shield

This treatment applies to the following species:
Manufacturer: ImmuCell

Developers of First Defense®

Bovine Rotavirus-Coronavirus-Escherichia Coli Antibody, Bovine Origin

FIRST DEFENSE® TRI-SHIELD® has been shown to be effective for passive immunity against K99+ E. coli, bovine coronavirus and bovine rotavirus when administered within 12 hours of birth.

Specifically, FIRST DEFENSE® TRI-SHIELD® aids in the reduction of:

● Mortality and morbidity from scours caused by K99+ E. coli and bovine coronavirus.

While also reducing:

● Severity and duration of scours caused by bovine rotavirus.

Directions For Use

Do not delay colostrum. For best results, FIRST DEFENSE® TRI-SHIELD® gel should be administered to calves orally, within 12 hours after birth. Remove the tube cap, placing the tip at the back of the throat. Initiate the plunger and squeeze the entire tube contents into the calf’s mouth, ensuring the calf swallows all of the gel.


Store refrigerated (35-46°F, 2-8°C). Do not split dose between multiple calves. Use entire contents when first opened. Blue dye is non-digestible serving as a tracker through the system to ensure calf received treatment. First fecal stool after administration will be blue in color. For use in animals only. Do not mix with other products, except as specified on the label. Preservative: Thimerosal.

U.S. Veterinary License No. 327

PCN 3625.R2


Manufactured by ImmuCell Corporation, 56 Evergreen Drive, Portland, ME 04103

Single-dose 30 cc gel tube; 12 tubes/box

Rev 1

CPN: 1120011.0

Telephone:   207-878-2770
Order Desk:   800-466-8235
Fax:   207-878-2117
Every effort has been made to ensure the accuracy of the First Defense Tri-Shield information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 Animalytix LLC. Updated: 2018-11-30