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Felocell CVR (Canada)

This page contains information on Felocell CVR for veterinary use.
The information provided typically includes the following:
  • Felocell CVR Indications
  • Warnings and cautions for Felocell CVR
  • Direction and dosage information for Felocell CVR

Felocell Cvr

This treatment applies to the following species:
Manufacturer: Pfizer

Feline Rhinotracheitis-calici-panleukopenia Vaccine

Modified Live Virus

For use in cats only

Product Description

Felocell CVR is for vaccination of healthy cats as an aid in preventing feline viral rhinotracheitis (FVR) caused by feline herpesvirus-1, feline respiratory disease caused by feline calicivirus (FCV), and feline panleukopenia (FPL) caused by feline parvovirus. Felocell CVR contains attenuated strains of feline rhinotracheitis virus, calicivirus, and panleukopenia virus (Johnson Snow Leopard strain), propagated in established cell lines. Felocell CVR is packaged in freeze-dried form with inert gas in place of vacuum.

Disease Description

FVR, caused by feline herpesvirus-1, is highly contagious, spreading both by horizontal (including aerosol) and in utero transmission from queen to kitten. It accounts for approximately 40-45% of feline respiratory infections.1 First signs of FVR are sneezing, fever, conjunctivitis, rhinitis, and salivation. An initial serous nasal and ocular discharge which rapidly becomes mucopurulent is typical of the disease. Ulcerative keratitis or glossitis may also occur. As FVR progresses, anorexia, depression, tracheitis, and bronchitis may be observed. Abortion or fetal resorption may occur. The prognosis is guarded if cats remain severely infected for more than 1 week. A carrier state lasting for years with periods of latency alternating with episodes of viral shedding is common. Although few adult cats die from FVR, death rate among affected kittens can range from 50-60%.

FCV infection is believed to account for another 40-45% of feline respiratory infections, and dual FCV-FVR infections are not uncommon.2 FCV infects oral mucous membranes as well as the respiratory tract. Buccal, nasal, and lingual ulcers are characteristic. Other clinical signs of the infection are similar to FVR: anorexia, depression, fever, salivation, and nasal discharge. A carrier state with persistent shedding occurs. FCV most severely affects kittens and debilitated cats, but overall death loss is generally low.

FPL, also known as feline distemper, was once one of the most widespread and serious diseases of cats but has been well controlled by vaccination programs. Highly contagious, FPL is transmitted both directly by contact with infected animals and indirectly by contact with contaminated objects. Clinical signs of FPL include fever, anorexia, vomiting, depression, and weakness; diarrhea may also occur, usually 2-4 days after onset of fever. Characteristic hematology includes a dramatic loss of circulating white cells. Particularly among kittens, FPL may result in high death loss. Cats that survive infection often remain debilitated for the remainder of their lives. Kittens infected in utero or within a few days after birth may suffer cerebellar damage clinically manifested by ataxia.

Safety And Efficacy

Safety of Felocell CVR was demonstrated in field trials involving 2,288 cats. No serious postvaccination reactions attributable to the vaccine were reported. Efficacy of Felocell CVR was determined by challenge-of-immunity tests. Vaccinated cats experienced significantly less severe clinical signs than nonvaccinated control cats after challenge with virulent FVR virus, FCV, or FPL virus. Efficacy of the FPL fraction in Felocell CVR was further established in a 3-year repeat antigenicity study. Three years after initial efficacy studies were conducted, FPL challenge tests were repeated. After challenge, all vaccinated cats remained clinically healthy while 80% of control cats developed clinical signs of FPL.

Results of serological studies indicated that no immunologic interference existed among the vaccine fractions. In specific-pathogen-free cats, vaccination with Felocell CVR stimulated serum neutralization titers to each of the 3 vaccinal viruses.

Directions

1. General Directions: Vaccination of healthy cats is recommended. Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, shake well, and administer 1 mL intramuscularly or subcutaneously.

2. Primary Vaccination: Healthy cats 12 weeks of age or older should receive 2 doses administered 3-4 weeks apart. Cats vaccinated at less than 12 weeks of age should be revaccinated at 12 weeks of age.

3. Revaccination: Annual revaccination with a single dose is recommended.

Precautions

1. Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

2. Use entire contents when first opened.

3. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

4. Burn containers and all unused contents.

5. Contains gentamicin as preservative.

6. Vaccination of pregnant queens should be avoided.

7. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

8. This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.

References

1. The Merck Veterinary Manual, 5th Ed., Otto H. Siegmund, ed. Rahway, Merck and Company, p. 324, 1979.

2. McLachlan NJ, Burgess GW: Feline viral respiratory tract infection. JAVMA 174:1345, 1979.

Technical inquiries should be directed to Pfizer Animal Health Technical Services, (800) 366-5288 (USA), (800) 461-0917 (Canada).

For veterinary use only

U.S. Veterinary License No. 189

Pfizer Animal Health, Exton, PA 19341, USA, Div. of Pfizer Inc., NY, NY 10017

9810

75-4305-22

® Registered trademark of Pfizer Products Inc; Pfizer Canada Inc., licensee

Presentation

Available in 25 x 1 dose vials with sterile diluent.

Nac No.

11980511
PFIZER ANIMAL HEALTH
Pfizer Canada Inc.

17300 TRANS-CANADA HIGHWAY, KIRKLAND, QC, H9J 2M5
Order Desk:   800-663-8888
Toll-Free:   877-633-2001
Technical Services Canada:   800-461-0917
Technical Services USA:   800-366-5288
Website:   www.pfizer.ca
Every effort has been made to ensure the accuracy of the Felocell CVR information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-06-29