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Enterisol SC-54 FF

This page contains information on Enterisol SC-54 FF for veterinary use.
The information provided typically includes the following:
  • Enterisol SC-54 FF Indications
  • Warnings and cautions for Enterisol SC-54 FF
  • Direction and dosage information for Enterisol SC-54 FF

Enterisol SC-54 FF

This treatment applies to the following species:
Company: Boehringer Ingelheim

Salmonella Choleraesuis Vaccine

Avirulent Live Culture

For use in swine only

Enterisol SC-54 FF Indications

Recommended for the vaccination of healthy, susceptible swine 3 weeks of age or older as an aid in the prevention of salmonellosis caused by Salmonella choleraesuis var. kunzendorf. Enterisol® SC-54 FF may be simultaneously administered orally to pigs along with Enterisol® Ileitis FF and/or Inglevac® ERY-ALC.


Vaccine Preparation: Plan vaccination of timing to allow thawing of the contents of the vaccine vial in a trickling cool water bath until liquid (usually 30-40 minutes). Shake well and use entire contents immediately. Do not thaw vaccine by removing from the freezer the day before use. This will inactivate the vaccine.

Vaccination via the drinking water:

Conventional Water Directions (open trough or barrel type [tank] system):

1. Do not thaw vaccine until ready to vaccinate.

2. Remove all medications, sanitizers and disinfectants from drinking water, and any medicated feeds, for a minimum of 72 hours (3 days) prior to and following vaccination.

3. Flush watering system with nonchlorinated/nontreated clean water to eliminate any antibacterial agents.

4. Thaw vaccine according to directions.

5. Add number of doses of vaccine equal to or more than the number of pigs to vaccinate, to the appropriate amount of clean, nontreated drinking water (see Caution Section).

6. Final solution containing vaccine should be consumed within 4 hours after rehydration of the vaccine.

Directions For Automatic Watering Systems Equipped With Proportioner:

Several types of medicators/proportioners are commercially available.

1. Do not thaw vaccine until ready to vaccinate.

2. Remove all medications, sanitizers, and disinfectants from drinking water, and any medicated feeds, for a minimum of 72 hours (3 days) prior to and following vaccination.

3. Provide sufficient watering space so that all pigs can drink within a 4-6 hour time frame.

4. Flush watering system with nontreated clean water to eliminate any antibacterial agents. (This can be accomplished during pre-measurement of stock solution volume requirement in step 6.)

5. Set proportioner to deliver 1 oz. (30 mL) of vaccine solution per 1 gallon (4 liters) of water. Regularly clean proportioners internally to remove antibiotics or other contaminants that may impair vaccine viability. Maintain proportioners to manufacturer’s specifications in order to safeguard accurate vaccine administration.

6. Pre-measure the actual stock solution volume requirement the day prior to vaccination using plain tap water surrogate stock solution. Allow pigs to drink for 4 hours during the same time of day as planned vaccination. Subtract the remaining water volume from the starting water volume to determine the net stock solution volume requirement.

7. Prepare vaccine stock solution as follows:

a. Thaw vaccine according to directions.

b. Add approximately half of the premeasured amount of clean, nontreated stock solution water to the container being used for the stock solution. To ensure vaccine viability, use a Ready Pack™ DT (or Reload Pack DT if reusing the Ready Pack container), which contains the stabilizer sodium thiosulfate, with any source of drinking and stock solution water. A blue dye is also included in the Ready Pack to facilitate charging the water lines and detection of the vaccine-containing water (step 8).

c. Add number of doses to the stock solution container equal to or more than the number of pigs to vaccinate. Then, add the other half of the premeasured amount of stock solution water.

d. Mix thoroughly.

8. Insert proportioner drawtube into the vaccine stock solution and direct water flow through the proportioner. Charge the water distribution lines with vaccine by draining (“bleeding”) water from the drinkers in the pens furthest away from the proportioner until the water appears light blue in color. Pigs should consume the vaccine-containing water within 4-6 hours of thawing the vaccine. Do not medicate or use disinfectants immediately following vaccination.

Enterisol SC-54 FF Caution

The actual amount of water consumed may vary considerably depending on several factors, including environmental temperature and drinker type. It is recommended to pre-measure the actual stock solution volume requirements the day prior to vaccination, during the planned vaccination time period.

This should be done in order to ensure that the vaccine is consumed within the 4-6 hour recommended time frame.

Incompatibility: All materials used in administration of this vaccine must be free of antibiotic and disinfectant residue to prevent vaccine inactivation and reduced product efficacy. A minimum antibiotic-free period (including feed antibiotics) of 3 days pre- and postvaccination is recommended.


Store frozen at -70°C. Do not store thawed vaccine. Do not thaw until immediately prior to use. After thawing, shake well and use entire contents immediately. Burn container and all unused contents. Do not use in pregnant swine or breeding boars. Do not use concurrently with antibiotics, including feed antibiotics. All materials used in administering this vaccine must be free of antimicrobial or disinfectant residue to prevent inactivation. Anaphylactic reactions may occur. Avoid contact. If accidental human exposure occurs, flush area with clean water & consult physician immediately.

Withdrawal Period: Vaccinated pigs are not to be harvested for human consumption within 21 days after vaccination.


Burn container and all unused contents by a procedure allowed by local, state, and Federal regulations.

Antidote: Epinephrine.

Additional Information for Veterinarians: Two field studies were conducted representing more than 50,000 total pigs. Non-vaccinated pigs and pigs vaccinated per label instructions via the drinking water when placed in the finishing barn (approximately 60 pounds body weight) were compared for prevalence of salmonella at slaughter. Contrasted with non-vaccinated pigs, vaccinated pigs had a significantly (p<0.05) lower prevalence of salmonella detected by culture of ileocecal lymph nodes collected at slaughter. In a clinical challenge study, pigs vaccinated intranasally with Enterisol® SC-54 (n=20) and non-vaccinated controls (n=10) were challenged with virulent Salmonella typhimurium 2 weeks post-vaccination. During the subsequent 14 days the challenge control pigs shed S. typhimurium, which was isolated from 18.0% of daily fecal samples from individual study pigs. Vaccination with Enterisol® SC-54 significantly (p<0.05) reduced fecal shedding of S. typhimurium. Only 7.5% of fecal samples from vaccinates were culture positive, a 2.4-fold reduction versus non-vaccinated controls.

Boehringer Ingelheim Vetmedica, Inc., St. Joseph, MO 64506 U.S.A.

U.S. Veterinary License No. 124

U.S. Patent No. 5,436,001

Copyright BIVI All Rights Reserved.

250 Doses/50 mL


500 Doses/100 mL


CPN: 1028136.1

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