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Dolmectin (45 mg) (Canada)

This page contains information on Dolmectin (45 mg) for veterinary use.
The information provided typically includes the following:
  • Dolmectin (45 mg) Indications
  • Warnings and cautions for Dolmectin (45 mg)
  • Direction and dosage information for Dolmectin (45 mg)

Dolmectin (45 mg)

This treatment applies to the following species:
Company: Vetoquinol

Selamectin topical solution

Veterinary Use Only

Topical Parasiticide for Dogs and Cats

DIN 02491176, DIN 02491192, DIN 02491214, DIN 02491184, DIN 02491206, DIN 02491222, DIN 02491230

Active Ingredient

Selamectin is a semi-synthetic compound of the avermectin class.

Product Description: Dolmectin topical solution is available as a colorless to yellow, ready to use solution in single dose applicators for topical (dermal) treatment of dogs and cats not less than six weeks of age. The content of each applicator is formulated to provide a minimum of 6 mg/kg of body weight of selamectin.

Indications: DOGS: For the treatment and control of flea (Ctenocephalides canis, C. felis), ear mite (Otodectes cynotis), sarcoptic mange mite (Sarcoptes scabiei) and tick (Rhipicephalus sanguineus) infestations, and for the prevention of heartworm disease caused by Dirofilaria immitis. Dolmectin is also indicated as an aid in the treatment and control of roundworm (Toxocara canis) infections and tick (Dermacentor variabilis) infestations.

CATS: For the treatment and control of flea (Ctenocephalides canis, C. felis) and ear mite (Otodectes cynotis) infestations, intestinal hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) infections, and for the prevention of heartworm disease caused by Dirofilaria immitis.

Dosage: Dolmectin topical solution is applied topically to the skin at the recommended minimum dose of 6 mg selamectin per kg of body weight, once a month.

Administer Dolmectin topical solution in accordance with the following tables:

Cats (kg)

Package color

mg per applicator

Potency
(mg/mL)

Administered volume
(nominal applicator sizes - mL)

≤2.5

Pink

15 mg

60

0.25

2.6-7.5

Blue

45 mg

60

0.75

7.6-10.0

Taupe

60 mg

60

1.0

>10.0

 

Appropriate combination of applicators

60

Appropriate combination of applicators


Dogs (kg)

Package color

mg per applicator

Potency
(mg/mL)

Administered volume
(nominal applicator sizes - mL)

≤2.5

Pink

15 mg

60

0.25

2.6-5.0

Purple

30 mg

120

0.25

5.1-10.0

Brown

60 mg

120

0.5

10.1-20.0

Red

120 mg

120

1.0

20.1-40.0

Teal

240 mg

120

2.0

>40

 

Appropriate combination of applicators

120

Appropriate combination of applicators

Administration:

Hold the applicator upright. Twist or snap back the tip. Remove cap and check to be sure tip of applicator is open. Part the hair at the base of the neck and place tip of applicator on visible skin area. Squeeze applicator 3-4 times in one spot until empty. Keep applicator compressed on the final squeeze to avoid drawing liquid back into applicator. While keeping applicator squeezed, drag it away from liquid and lift up to remove. Ensure the applicator is empty. Do not apply when the hair coat is wet. Bathing or shampooing the animal 2 or more hours after treatment will not reduce the efficacy of Dolmectin topical solution. Discard the used applicator in household trash.

Contraindications

Do not use in sick, debilitated or underweight animals.

Cautions:

Dolmectin topical solution may be safely administered to heartworm infected dogs and cats, however, it is recommended, in accordance with good veterinary practice, that all dogs ≥ 6 months of age be tested for existing heartworm infections before beginning medication with Dolmectin topical solution. Cats ≥ 6 months of age in heartworm endemic areas may also be tested to determine the presence of existing heartworm infections before beginning medication with Dolmectin topical solution. Dolmectin topical solution is not effective against adult D. immitis; however it may decrease the number of circulating microfilariae.

Dolmectin topical solution should be used in animals six or more weeks of age.

Warnings

Keep out of reach of children.

May be irritating to skin and eyes. Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with the eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately.

Adverse Reactions

The following adverse reactions are based on voluntary post-approval global adverse drug experience reporting (excluding European countries). Not all adverse events are reported. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data.

The following adverse events are listed in decreasing order of reporting frequency:

CATS: Application site hair change, lack of expected efficacy, lethargy, anorexia, emesis, application site pruritus or lesion or erythema, diarrhea, ataxia and death. Product causality could not be confirmed in the majority of cases with fatal outcome.

DOGS: Lack of expected efficacy, emesis, lethargy, diarrhea, anorexia, pruritus, convulsion, application site hair change, ataxia, and muscle tremor. As with other macrocytic lactones, the reversible neurological signs listed have been rarely observed after the use of selamectin topical solution. In the majority of lack of expected efficacy reports the product causality could not be confirmed. Owner’s compliance and strict adherence to the product’s dosage, treatment schedule and duration as well as consideration of specific parasite biology are of utmost importance in insuring success in parasite treatment and/or prevention.

Collies and other herding breeds are known to be more sensitive to the marcocyclic lactone class of medications. Signs of toxicity that can be seen with overdose include: depression, hypersalivation, tremor and ataxia.

Although adverse reactions may occur with use of any pharmaceutical product, it is recommended that any sign of new illness observed during the treatment with selamectin topical solution is thoroughly investigated.

Efficacy

Flea Control in Dogs and Cats

If the dog or cat is already infested with fleas when the first dose of Dolmectin topical solution is administered, then adult fleas on the animal are killed and no viable flea eggs are produced after the first administration. This stops flea reproduction. An environmental infestation of fleas may persist for a short time after beginning treatment with Dolmectin topical solution because of the emergence of adult fleas from pupae. However, large reductions in flea infestations are observable after just one monthly treatment as flea larvae in the animal surroundings are killed or prevented from developing to adults by treatment with Dolmectin topical solution.

For the lasting control of flea infestations, Dolmectin topical solution should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. This ensures that fleas infesting the animals are killed and that no viable flea eggs are produced by these fleas. This breaks the flea life cycle and controls flea infestations. Results of clinical field efficacy studies using selamectin topical solution monthly demonstrated control of flea infestations and improved the clinical manifestation of flea infestations, including flea allergy dermatitis.

Heartworm Prevention in Dogs and Cats

For the prevention of heartworm disease, Dolmectin topical solution must be administered on a monthly basis. Dolmectin topical solution may be administered year-round or at least within one month after the animal’s first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Dolmectin topical solution and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventative product in a heartworm disease prevention program, the first dose of Dolmectin topical solution must be given within a month of the last dose of the former medication.

Ear Mite Treatment in Dogs and Cats

For the elimination of ear mites (O. cynotis) in dogs and cats, Dolmectin topical solution should be administered once as a single dose. A second monthly dose of Dolmectin topical solution may be required to eliminate mites in some dogs. Monthly use of Dolmectin topical solution will treat any subsequent ear mite infestations. Many animals treated for otoacariasis have concurrent otitis externa involving secondary yeast or bacterial infections. O. cynotis causes primary inflammation and pruritus of the external ear canal and predisposes to these secondary infections. Therefore, cats and dogs with otoacariasis complicated by secondary yeast and/or bacterial infections may require supportive therapy in addition to treatment with Dolmectin topical solution. Cleansing of the infested ears is recommended to remove the debris.

Nematode Treatment in Dogs and Cats

For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections in cats, Dolmectin topical solution should be applied once as a single treatment, and monthly thereafter to control infections.

As an aid in the treatment of intestinal worms (T. canis) infections in dogs, administer two monthly treatments, and monthly thereafter to control infections.

Sarcoptic Mange Treatment in Dogs

A single dose of Dolmectin topical solution is safe and highly efficacious against natural infestations of S. Scabiei in dogs, however, for complete eradication two doses may be required. Monthly use of Dolmectin topical solution will treat any subsequent Sarcoptes mite infestations.

Tick Treatment in Dogs

For tick (Rhipicephalus sanguineus, Dermacentor variabilis) infestations, Dolmectin topical solution should be administered on a monthly basis. In heavy tick infestations, adequate efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter.

Animal Safety:

DOGS: Selamectin topical solution has been tested with no adverse reactions in dogs of over 100 different pure and mixed breeds including Collies, and in pregnant and lactating females, breeding males and females, and puppies six weeks of age and older. Selamectin topical solution was administered at 10 times the recommended dose, and no adverse effects were observed. Selamectin topical solution was also at 3 times the recommended dose to heartworm infected dogs, and no adverse effects were observed.

CATS: Selamectin topical solution has been tested with no serious adverse effects in cats over 15 different pure and mixed breeds and in pregnant and lactating females, breeding males and females and kittens six weeks of age and older. Less than 1% of cats treated in the field studies had a transient alopecia at or near the site of application, possibly due to self-grooming. In safety studies, selamectin topical solution was applied at 10 times the recommended dose, and no adverse effects were noted. Selamectin topical solution was also applied at 4 times the recommended dose to heartworm infected cats, and no adverse effects were observed. Accidental oral administration of selamectin topical solution to cats may induce salivation or vomiting.

In well-controlled clinical studies, selamectin topical solution was used safely in animals receiving other frequently used veterinary products such as vaccines, antiparasitics, antibiotics, steroids, pesticides and shampoos.

Storage Conditions: Dolmectin topical solution applicators should be stored in the original carton between 15°C and 30°C. Flammable - Keep away from heat, sparks, open flames or other sources of ignition.

Presentation: Dolmectin comes in the following strengths of 15, 45 and 60 mg for cats and 15, 30, 60, 120 and 240 mg for dogs.

Manufactured by:

Norbrook Laboratories Limited, Newry, BT35 6PU, Co. Down, Northern Ireland

Distributed by:

Vetoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada, J5T 3S5

222491I02

 

 

 

Code

0.25 mL
60 mg/mL

THREE SINGLE-DOSE APPLICATORS EACH CONTAINING 0.25 ML (15 MG) OF SELAMECTIN

Topical parasiticide for PUPPIES OR KITTENS ≤ 2.5 KG IN WEIGHT and at least 6 weeks of age

458593

0.25 mL
120 mg/mL

SIX SINGLE-DOSE APPLICATORS EACH CONTAINING 0.25 ML (30 MG) OF SELAMECTIN

Topical parasiticide for DOGS 2.6 - 5.0 KG IN WEIGHT

458596

0.75 mL
60 mg/mL

SIX SINGLE-DOSE APPLICATORS EACH CONTAINING 0.75 ML (45 MG) OF SELAMECTIN

Topical parasiticide for CATS 2.6 - 7.5 KG IN WEIGHT

458594

0.5 mL
120 mg/mL

SIX SINGLE-DOSE APPLICATORS EACH CONTAINING 0.5 ML (60 MG) OF SELAMECTIN

Topical parasiticide for DOGS 5.1 - 10 KG IN WEIGHT

458597

1.0 mL
60 mg/mL

SIX SINGLE-DOSE APPLICATORS EACH CONTAINING 1.0 ML (60 MG) OF SELAMECTIN

Topical parasiticide for CATS 7.6 - 10 KG IN WEIGHT

458595

1.0 mL
120 mg/mL

SIX SINGLE-DOSE APPLICATORS EACH CONTAINING 1.0 ML (120 MG) OF SELAMECTIN

Topical parasiticide for DOGS 10.1 - 20.0 KG IN WEIGHT

458598

2.0 mL
120 mg/mL

SIX SINGLE-DOSE APPLICATORS EACH CONTAINING 2.0 ML (240 MG) OF SELAMECTIN

Topical parasiticide for DOGS 20.1 - 40.0 KG IN WEIGHT

458599

CPN: 1234463.1

VETOQUINOL N.-A. INC.
Commercial Division

2000, CHEMIN GEORGES, LAVALTRIE, QC, J5T 3S5
Telephone:   450-586-2252
Order Desk:   800-363-1700
Fax:   450-586-4649
Website:   www.vetoquinol.ca
Email:   info@vetoquinol.ca
Every effort has been made to ensure the accuracy of the Dolmectin (45 mg) information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2021 Animalytix LLC. Updated: 2021-10-04