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Coliprotec F18 (Canada)

This page contains information on Coliprotec F18 for veterinary use.
The information provided typically includes the following:
  • Coliprotec F18 Indications
  • Warnings and cautions for Coliprotec F18
  • Direction and dosage information for Coliprotec F18

Coliprotec F18

This treatment applies to the following species:
Manufacturer: Elanco

Escherichia coli Vaccine

Avirulent Live Culture, Porcine Isolate

FOR ORAL USE ONLY IN SWINE

Coliprotec F18 Indications

Coliprotec® F18 is a bacterial live vaccine recommended for the vaccination of healthy pigs, 18 days of age and older, as an aid in: a) the prevention of clinical signs due to post-weaning diarrhea caused by F18-positive enterotoxigenic E. coli, b) the prevention of clinical signs and mortality due to edema disease caused by F18-positive shigatoxin-producing E. coli and c) the reduction of fecal shedding of F18-positive enterotoxigenic E. coli.

Precautions

- Keep frozen until use at -70 to -80°C (-158 to -176°F).

- The vaccine is stable for 4 weeks (1 month) when stored at -22°C to -13°C. Vaccines should not be stored in the freezer door.

- For oral use only.

- Materials and water used for the preparation and administration of the vaccine must be free of antibiotic, detergent and disinfectant residues to prevent inactivation of the vaccine.

- Do not administer antibiotics or other live vaccines for a minimum of 3 days prior to and after vaccination.

- Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination.

- Use entire content when first opened.

- The solution containing the vaccine should be consumed within 4 hours.

- Do not vaccinate within 21 days before slaughter.

Warning

Anaphylactic reactions may occur. Use epinephrine as antidote. Dispose unused product and empty containers according to local waste disposal requirements.

Coliprotec F18 Dosage And Administration

The Coliprotec® F18 vaccine is administered orally using one dose per pig. Three methods of administration are recommended, being: 1. Individual oral drench; 2. Conventional drinking water systems (bowls, tanks); 3. Automatic medicator (proportioner, dosing pump) watering system.

Directions For Administration

Thaw the vaccine vial immediately prior vaccination in a refrigerator (2 - 8°C) or in a cool water bath until complete thawing. In case of concerns about the presence of disinfectant residues in the drinking water, it is recommended to add skimmed milk powder as a stabilizer into the drinking water prior to adding the vaccine. The final concentration of the skimmed milk powder should be 5 g / liter.

Individual oral drench

Water used for preparation or for administration of the vaccine must be free of antibiotic, detergent and disinfectant residue to prevent inactivation of the vaccine. Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination. Transfer the thawed vaccine to a graduated sterile container. Rinse the bottle with 10 mL of water and transfer the content into the same container. Dilute the vaccine in the container with water to obtain a final volume of 3 mL per dose. Shake well. Using a syringe or a drencher, administer a 3-mL oral single dose of the vaccine preparation per pig.

Conventional drinking water system (bowls, tanks)

Water used for preparation or for administration of the vaccine must be free of antibiotic, detergent and disinfectant residue to prevent inactivation of the vaccine. Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination. Flush the watering system with untreated water. Withhold water for 1 to 2 hours immediately before vaccination. Ensure that pigs can drink easily in 4 hours by providing adequate watering space.

On the day prior to vaccination, at the hour scheduled for the vaccination, determine the volume (mL) of water consumed within 4 hours by the number of pigs to be vaccinated after they have been deprived of water for a period of 1 to 2 hours. If the information is not available, please refer to the table below. Transfer the thawed vaccine to a sterile graduated container. Rinse the vial with 10 mL of water and transfer the content into the same graduated container. Dilute the vaccine with the determined volume of water. Shake well. Add the volume of vaccine solution to the drinking water bowls or tanks for the number of pigs to be vaccinated. The solution containing the vaccine should be consumed within 4 hours.

Automatic medicator watering system (proportioner, dosing pump)

Water used for preparation or for administration of the vaccine must be free of antibiotic, detergent and disinfectant residue to prevent inactivation of the vaccine. Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination. Flush the watering system and the proportioner with untreated water. Withhold water for 1 to 2 hours immediately before vaccination. Ensure that pigs can drink easily in 4 hours by providing adequate watering space.

On the day prior to vaccination, at the hour scheduled for the vaccination, determine the volume of stock solution to be prepared for the number of pigs to be treated. In order to do so, pre-fill the proportioner container with a known volume of water and determine the volume (mL) consumed within 4 hours by the number of pigs to be vaccinated after they have been deprived of water for a period of 1 to 2 hours. If the information is not available, please refer to the table below. Select the volume of the proportioner for 30 mL of stock solution per 4 liters of water (1 oz per gallon or 1:128).

Preparation of the vaccine stock solution: Use the number of doses equal to the number of pigs to be vaccinated. Transfer the thawed vaccine in the proportioner container. Rinse the vial with 10 mL of water and transfer the content into the same container. Add the volume of water to reach the determined volume of stock solution. Mix well. Insert the tube of the proportioner into the vaccine stock solution and open the water system. The solution containing the vaccine should be consumed within 4 hours.

Reference Table For Water Consumption

Water consumption is affected by environmental temperature, management conditions, and the age of pigs. The following table serves as a guideline.

Body weight

Water consumption per 100 pigs in a 4-hour period

Volume of stock solution to be prepared per 100 pigs1

4.5 Kg

11 L

85 mL

6.8 Kg

17 L

130 mL

9.0 Kg

23 L

175 mL

1Proportioner set at 30 mL per 4 litres (1 oz per gallon or 1:128)

Manufactured for Prevtec Microbia, Inc. • Can. Vet. Bio. Est. Lic. No.: 60

3395 Casavant Blvd. West • Saint-Hyacinthe (Québec) • Canada • J2S 0B8

Tel.: 450-774-7000 • Fax: 450-774-8777

Manufactured by Saskatchewan Research Council

Saskatoon (SK) • Canada

Distributed by Elanco Division Eli Lilly Canada, Inc., 150, Research Lane, Suite 120, • Guelph, • Ontario, • Canada • N1G 4T2

Tel.: 1-800-265-5475

COLIPROTEC® is a registered trademark of Prevtec Microbia Inc., used under license.

PKI-RA-0016 v03

Presentation: 200 doses and 500 doses.

NAC No.: 1184075.1

ELANCO, Division Eli Lilly Canada Inc. & ELANCO CANADA LIMITED (successor to Novartis Animal Health Canada Inc.)
RESEARCH PARK CENTRE, 150 RESEARCH LANE, SUITE 120, GUELPH, ON, N1G 4T2
Telephone:   519-821-0277
Order Desk:   800-773-7603
Fax:   519-821-7831
Elanco Canada Limited Customer Service Telephone:   800-387-6325
Elanco Canada Limited Customer Service Fax:   800-827-5782
Website:   www.Elanco.ca
Every effort has been made to ensure the accuracy of the Coliprotec F18 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2017 North American Compendiums. Updated: 2017-10-31

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