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C.E.T. OraStrip Dental Diagnostic Test

This page contains information on C.E.T. OraStrip Dental Diagnostic Test for veterinary use.
The information provided typically includes the following:
  • C.E.T. OraStrip Dental Diagnostic Test Indications
  • Warnings and cautions for C.E.T. OraStrip Dental Diagnostic Test
  • Direction and dosage information for C.E.T. OraStrip Dental Diagnostic Test

C.E.T. OraStrip Dental Diagnostic Test

This treatment applies to the following species:
Company: Virbac

Canine periodontal disease detection technology

For Animal Use Only

Product Information

C.E.T.® OraStrip® Dental Diagnostic Test is a point-of-care device for the detection and monitoring of active periodontal disease. It measures the presence and severity of periodontal infection in dogs. It should be used only as directed. Regular use of OraStrip Dental Diagnostic Test as a part of routine patient work-up has been shown to detect and monitor underlying active periodontal disease typically underdiagnosed by a visual clinical examination of the gums.

Intended Use

● For routine use by veterinary professionals in the awake dog for the detection and monitoring of active periodontal disease. Also appropriate for use in dogs scheduled to undergo examination under anesthesia. In these dogs, the OraStrip Test is intended for use prior or subsequent to premedication, but before administration of any anticholinergic or anesthetic agents that may cause dry mouth.

● For use in conjunction with routine visual clinical exams, as active periodontal disease is typically underdiagnosed by a routine visual clinical exam but is detected through use of the OraStrip Test.

● Should not be used with overtly bleeding gums, as blood interferes with the ability to read and interpret the test result.

(1) In Dogs Without Documented History of Periodontal Disease

Use in conjunction with routine oral examinations in the awake patient during wellness exams, at least twice a year.

● For patients with an OraStrip Test result of 1 and higher, further dental diagnostic evaluation and/or therapeutic plans may be recommended and discussed with the client.

● Discuss wellness, preventive dental care and daily oral health maintenance with the client to ensure optimal home care.

(2) In Dogs With Documented History of Periodontal Disease

Use every 3 to 6 months during follow-up evaluations to monitor active periodontal disease.

● Use in conjunction with the oral examination in the awake animal.

● If the patient is scheduled for a dental or other procedure under general anesthesia, the OraStrip Test should be used prior to the administration of general anesthetic.

OraStrip Test result obtained during follow-up evaluation should be compared to previous OraStrip Test result to determine effectiveness of treatment plan, evaluate client compliance, and revise treatment plan recommendations as needed.

For further diagnostic recommendations, see AAHA* Dental Care Guidelines (2013) J Am Anim Hosp Assoc. 49:75-82.

*AAHA is a registered trademark of the American Animal Hospital Association.

Instructions for Use

Note: When collecting saliva sample from dogs, typical protective equipment routinely employed in veterinary practice should be worn.

Remove the protective pouch from the comparator card. Then remove the OraStrip Test from its protective pouch, taking care not to touch the small pad located atop the strip.

Sample Collection

In general, particulate matter and blood will interfere with proper interpretation of the result. It is important to glide the pad gently along the gingival margin, where the teeth meet the gums, so as not to induce bleeding. When obtaining a sample, avoid applying excessive pressure, which could dislodge plaque and obscure the test result.

● Place your index finger behind the non-pad side of the OraStrip Test.

● Lift the dog’s upper lip.

● Gently glide the pad along the entire maxillary facial (buccal and labial) gingival margin, where the gums meet the teeth.
- This procedure draws a mixed gingival crevicular/salivary fluid into the pad and should take no more than 5-10 seconds.

● Remove the test strip from the dog’s mouth.

● Wait 10 seconds and read the result.


> Place your index finger behind the non-pad side of the OraStrip Test.


> Gently lift dog’s upper lip.


> Gently glide pad along entire maxillary facial gingival margin, where the gums meet the teeth.


> Wait 10 seconds. Compare color developed on the pad to colors on comparator card.

Reading the Result

● Hold the test strip near the numbered colors shown on the comparator card.

● Determine and record the number of the color closest to the color observed on the pad.

● If the color on the pad is not uniform, use the most intense color seen on the pad. A non-uniform color is still a valid result. This can occur if the gingival tissues are very dry or if periodontal infection is localized or unevenly distributed throughout the mouth.

● Read the test results within 5 minutes after sample collection.

Interpreting the Result

The numerical result recorded is interpreted as follows:

0 - indicates an inactive periodontal status not associated with periodontal infection. Based on patient history, professional recommendations may include: initiation or continuation of dental prophylaxis and home care. For dogs with a history of periodontal disease, this value reflects favourable ongoing management of active periodontal disease, and continuation of maintenance treatment modalities may be warranted.

1 or above - indicates active periodontal disease beneath the gumline. Based upon patient history, professional recommendations may include: dental cleaning, treatment, home care or further dental diagnostic evaluation.

Discuss with your client the importance of following your dental care recommendations between visits and returning for a follow-up appointment.

Interfering Substances

Highly pigmented substances such as blood will interfere with the ability to read and interpret the result. Therefore, the sample should be gently collected in such a way that no blood contacts the pad of the test strip. Similarly, avoid contacting heavy plaque deposits during sample collection; these also can obscure the test results.

Principle of Operation

Upon contact with a saliva sample (obtained from the gingival margin), OraStrip Dental Diagnostic Test provides an objective visual signal related to the concentration of thiols (also called mercaptans or sulfhydryl compounds) present in the sample. Thiols are produced by microorganisms closely associated with active periodontal disease. When left untreated, active periodontal disease can lead to progressive tissue destruction and loss of tooth attachment. In addition, periodontal disease is associated with cardiovascular, renal, and hepatic diseases and other serious conditions adversely impacting quality of life.

Clinical Background

OraStrip Dental Diagnostic Test directly measures the concentration of thiols in canine saliva from the gingival margin. Thiols measured by OraStrip Dental Diagnostic Test provide a direct indication of the severity of active periodontal infection. Regular use of OraStrip Dental Diagnostic Test as part of routine patient work-up has been shown to detect and monitor underlying active periodontal disease. Clinical data have associated low strip values with healthy periodontal status and the absence of periodontal infection.1 In dogs, active periodontal disease involves infection of the gums by anaerobic microorganisms including those from the genera Porphyromonas (such as P. gingivalis) and Treponema (such as T. denticola).2 When such microbes are present within subgingival biofilms, they are known to produce large quantities of metabolic products called thiols3 that can disrupt gum tissue and destroy healthy bone by inducing bone loss. Thiols disrupt epithelial integrity;4 cause death of gingival epithelial cells through apoptosis;5 and induce bone loss through stimulation of osteoclasts6 and inhibition of osteoblasts.7 In dogs, periodontal disease is associated with adverse systemic outcomes,8 as well as with hepatic, renal, and cardiovascular lesions.9

Literature Cited

1. Manfra Marretta S, Leesman M, Burgess-Cassler A, McClure GD Jr, Buelow M, Finn M (2012). Can Vet J. 53:1260-1265; Queck KE (data on file).

2. Isogai H, Kosako Y, Benno Y, Isogai E (1999). Zentralbl Veterinarmed B. 46(7):467-473; Hardham J, Dreier K, Wong J, Sfintescu C, Evans RT (2005). Vet Microbiol. 106(1-2):119-128; Nordhoff M, et al (2008). Vet Microbiol. 127:334-342.

3. Yoshida A, Yoshimura M, Ohara N, Yoshimura S, Nagashima S, Takehara T, Nakayama K (2009). J Periodontal. 80(11):1845-1851; Chen W, Kajiya M, Giro G, Ouhara K, Mackler HE, Mawardi H, Boisvert H, Duncan MJ, Sato K, Kawai T (2010). Biochem Biophys Res Commun. 391(1):645-650.

4. Ng W, Tonzetich J (1984). J Dent Res. 63(7):994-997; Johnson P, Yaegaki K, Tonzetich J (1996). J Periodontal Res. 31(5):323-329.

5. Calenic B, Yaegaki K, Murata T, Imai T, Aoyama I, Sato T, Ii H (2010). J Periodontal Res. 45(1):31-37.

6. Irie K, Ekuni D, Yamamoto T, Morita M, Yaegaki K, Ii H, Imai T (2009). Arch Oral Biol. 54(8):723-729; Ii H, Imai T, Yaegaki K, Irie K, Ekuni D, Morita M (2010). J Periodontal. 81(11):1691-1697.

7. Imai T, Ii H, Yaegaki K, Murata T, Sato T, Kamoda T (2009). J Periodontol. 80(12):2028-2034.

8. Rawlinson JE, Goldstein RE, Reiter AM, Attwater DZ, Harvey CE (2011). J Am Vet Med Assoc. 238(5):601-609.

9. DeBowes LJ, Mosier D, Logan E, Harvey CE, Lowry S, Richardson DC (1996). J Vet Dent. 13(2):57-60.

To reorder, please talk to your distributor or Virbac representative.

Store at room temperature, 59° to 75°F (15° to 24°C). Avoid areas with excessive moisture.

Mfd. for and dist. in USA by: Virbac AH, Inc., PO Box 162059, Fort Worth, Texas 76161 USA

Tel. 800-338-3659

Distributed in Canada by: Virbac Canada Inc., 1400-340 Albert Street, Ottawa, Ontario, K1R 0A5

All rights reserved.

PN 101-0014, rev. C



Product code:


24 CT.




CPN: 1023138.0

Virbac Corporation

P.O. BOX 162059, FORT WORTH, TX, 76161
Telephone:   817-831-5030
Order Desk:   800-338-3659
Fax:   817-831-8327
Every effort has been made to ensure the accuracy of the C.E.T. OraStrip Dental Diagnostic Test information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2019 Animalytix LLC. Updated: 2019-09-30