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ButaTabs E

This page contains information on ButaTabs E for veterinary use.
The information provided typically includes the following:
  • ButaTabs E Indications
  • Warnings and cautions for ButaTabs E
  • Direction and dosage information for ButaTabs E

ButaTabs E

This treatment applies to the following species:
Manufacturer: Henry Schein® Animal Health

(Phenylbutazone Tablets, USP) 1 gram


For Oral Use in Horses Only


NADA 91-818, Approved by FDA

ButaTabs E Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Phenylbutazone chemically is 4-butyl-1, 2 diphenyl-3, 5-pyrazolidinedione.


Mol. Wt. 308.38

Each tablet contains 1 g of phenylbutazone.

BACKGROUND PHARMACOLOGY: Phenylbutazone was first synthesized in 1948 and introduced into human medicine in 1949. Kuzell (1), (2), (3), Payne, (4), Fleming, (5) and Denko, (6) demonstrated the clinical effectiveness of phenylbutazone in gout, gouty arthritis, acute arthritis, acute rheumatism and various other rheumatoid disorders in humans. Fabre (7), Domenjoz, (8), Wilhelmi, (9) and Yourish, (10), have established the anti-rheumatic and anti-inflammatory activity of phenylbutazone. It is entirely unrelated to the steroid hormones.

Toxicity of phenylbutazone has been investigated in rats and mice (11), and dogs (12).

Phenylbutazone has been used by Camberos (13), in thoroughbred horses. Favorable results were reported in cases of traumatism, muscle rupture, strains and inflammations of the third phalanx. Results were not as favorable in the periodic treatment of osteoarthritis of the stifle and hip, arthrosis of the trapezious muscles and general arthritis. Sutter, (14) reported a favorable response in chronic equine arthritis of long duration, fair results in severely bruised mare and poor results in two cases where the condition was limited to the third phalanx.

ButaTabs E Indications

Phenylbutazone is for the relief of inflammatory conditions associated with the musculoskeletal system in horses.

Dosage and Administration

For Horses Only: Orally 1 to 2 tablets per 500 pounds of body weight, but not to exceed 4 g per animal daily. Use high dose for the first 48 hours, then gradually reduce to a maintenance dose.


Use with caution in patients who have history of drug allergy.

PRECAUTION: In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy should be used concurrently.


Not for horses intended for food.

How Supplied

Tablets containing 1 gram of phenylbutazone are supplied in bottles of 100 tablets.

DISPENSE in tight, child-resistant containers.

Store at controlled room temperature, 20° to 25°C (68° to 77°F)


1. Kuzell, W.C., Schaffarzick, R.W., Naughler, W.E., Gandia, G. and Mankle, E.A.: A.M.A. Arch, Inst. Med., 92; 646 (1953).

2. Kuzell, W.C., Schaffarzick, R.W., Brown, B. and Mankle, E.A.: J.A.M.A. 149; 729 (1952).

3. Kuzell, W.C. and Schaffarzick, R.W.: Calif. Med. 77; 319 (1952).

4. Payne, R.W., Shelter, M.R., Farr, C.H., Hellbaum, A.A. and Ishmall, W.K.: J. Lab. Clin. Med. 45; 331 (1955).

5. Fleming, J. and Will, G.: Ann. Rheumat., Dis., 12; 95 (1953).

6. Denko, C.W. and Rumi, D.: American Pract. 6; 1865 (1955).

7. Fabre, J., et al: Semain. Hop. (Paris) 31; 87 (1955).

8. Domenjoz, R., et al: Arzneimittel-Forsch, 5; 488 (1955).

9. Wilhelmi, G. and Pulver, R.: Arzneimittel-Forsch, 5; 221 (1955).

10. Yourish, W., Paton, B., Brodie, B., Burns, J.: A.M.A. Arch. Ophth., 53: 264 (1955).

11. Hazelton, L.W., Tusing, T.W. and Hollana, E.G.: J. Pharmacol. Exper. Ther., 109; 387 (1953).

12. Ogilvie, F.B. and Sutter, M.D.: Vet. Med. 52; 492-4 (1957).

13. Camberos, H.R.: Rev. Med. Vet. (Buenos Aires) 38; 9 (1956).

14. Sutter, M.D.: Vet. Med., 53; 83 (Feb. 1958).

Distributed Exclusively by: Butler Animal Health Supply, Dublin, OH 43017

Rev. 04-00



Reorder #:


100 Tablets



801021 Rev0106

NAC No.: 10822513

Telephone:   614-761-9095
Toll-Free:   1-855-724-3461
Every effort has been made to ensure the accuracy of the ButaTabs E information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

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