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Brucella Abortus Vaccine (Strain RB-51)

This page contains information on Brucella Abortus Vaccine (Strain RB-51) for veterinary use.
The information provided typically includes the following:
  • Brucella Abortus Vaccine (Strain RB-51) Indications
  • Warnings and cautions for Brucella Abortus Vaccine (Strain RB-51)
  • Direction and dosage information for Brucella Abortus Vaccine (Strain RB-51)

Brucella Abortus Vaccine (Strain RB-51)

This treatment applies to the following species:
Company: Professional Biological


General Information

Brucellosis or “Bangs Disease” is a contagious disease of cattle caused by the gram negative bacterium Brucella abortus. The disease in animals is characterized by abortion, retained placenta and to a lesser extent, orchitis and infection of the accessory sex glands in males. Brucellosis primarily affects cattle, buffalo, bison, pigs, sheep, goats, dogs, elk and occasionally horses. The disease in man is called Undulant Fever.

Control and elimination of this disease in cattle involves testing and culling reactors and vaccinating healthy females.

Brucella Abortus Vaccine, Strain RB-51, Live Culture, Code 1261.00 was first licensed in 1996. It has been used exclusively since than as part of the federal program to eradicate brucellosis from the United States because it is safe, effective and does not interfere with diagnostic testing for infection.

Brucella Abortus Vaccine, RB-51, is the result of research, development and production efforts by both the public and private sectors. It was selected as a stable strain which produces protective immunity while not inducing antibodies which react in standard serological tests. RB-51 has been tested to verify safety, efficacy and to demonstrate that there is no serological reaction in standard tests.

The Animal and Plant Health Inspection Service of the US Department of Agriculture with cooperation of the Centers for Disease Control conducted a risk analysis to assess the potential effect of this product on the safety of animals, public health, and the environment. Based on the risk analysis, APHIS prepared an environmental assessment (EA). APHIS concluded that the licensure of this veterinary biological product would not significantly affect the quality of the human environment (FONSI).

Distribution in the United States shall be limited to authorized recipients designated by proper state officials under such additional conditions as these authorities may require.

For use by or under the supervision of a veterinarian.


For use in healthy female cattle 4 to 12 months of age as an aid in the prevention of infection and abortion caused by Brucella abortus.

Do not administer to pregnant cows.

Do not vaccinate within 3 weeks before slaughter. Rehydrate with accompanying vial of sterile diluent supplied as a component part of this package. Shake well after rehydration. Administer 2.0 ml subcutaneously.


Anaphylactoid reaction may occur following administration of products of this nature. If noted, administer adrenalin or equivalent.


1. Store at 2° to 7° C.

2. Use entire contents when first rehydrated.

3. Burn, autoclave or chemically disinfect this container and all unused contents.

4. In the case of accidental human exposure contact a physician.
Warning: This organism is Rifampin and Penicillin resistant.

5. Diluent is buffered solution specifically prepared for use with this vaccine. Use only this diluent to assure viability of the vaccine.

6. Conveniently packaged in 25 dose, and 5 dose sizes.

USDA Code 1261.00

U.S. Vet. License No. 188

PROFESSIONAL BIOLOGICAL COMPANY, 4950 York Street, Denver, CO. 80216 U.S.A.

Phone: 303-295-7527

Contact us for more information on other Professional Biological Company products.

Fine Veterinary Biologics since 1923.


CPN: 14250001

4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216
Telephone:   303-295-7527
Order Desk:   800-525-2065
Fax:   303-295-1923
This service and data are provided "AS IS". DVMetrics and assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics and services and data. See the terms of use for further details.

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