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BNPH (Canada)

This page contains information on BNPH for veterinary use.
The information provided typically includes the following:
  • BNPH Indications
  • Warnings and cautions for BNPH
  • Direction and dosage information for BNPH


This treatment applies to the following species:
Company: Vetoquinol

Neomycin and Polymyxin B Sulfates, Bacitracin and Hydrocortisone Acetate Ophthalmic Ointment, USP


DIN 00517917


Active Ingredients

per g

Bacitracin Zinc

400 IU

Neomycin Sulfate (Equivalent to 3.4 mg of neomycin base)

5 mg

Polymyxin B Sulfate

5 000 IU

Hydrocortisone Acetate

10 mg

ACTIONS: The overlapping spectra of these three antibiotics provide effective bactericidal action against most commonly occurring gram-positive and gram-negative bacteria associated with infections of the eyes. The range of bactericidal activity encompasses many bacteria which are, or have become, resistant to other antibiotics notably Pseudomonas and Staphylococcus. In susceptible organisms, resistance rarely develops, even on repeated or prolonged use. Hydrocortisone acetate exerts a marked anti-inflammatory action at the tissue level and effectively suppresses inflammation in many disorders of the anterior segment of the eye. Local application to the eye often gives rapid relief of pain and photophobia, particularly in lesion of the cornea.

The combined anti-inflammatory and antimicrobial activity of Bacitracin-Neomycin-Polymyxin with Hydrocortisone ointment permits effective management of many disorders of the anterior segment of the eye where combined activity is needed.

BNPH Indications

It may be used as an aid in acute or chronic conjunctivitis in dogs and cats, when caused by organisms susceptible to the antibiotics contained in this ointment. Laboratory test should be conducted including in vitro culturing and susceptibility tests on samples collected prior to treatment.


Ophthalmic preparations containing corticosteroids are contraindicated in the treatment of those deep, ulcerative lesions of the cornea where the inner layer (endothelium) is involved, in fungal infections and in the presence of viral infections.

DOSAGE & ADMINISTRATION: Apply a thin film over the cornea three or four times daily. The area to be treated should be properly cleansed prior to use. Foreign bodies, crusted exudates and debris should be carefully removed. Treatment can be continued for two days after the eye appears normal, or as recommended by a veterinarian.

CAUTIONS: Neomycin has been reported to cause allergic reactions in dogs and cats, particularly after prolonged usage. Neomycin containing products should be avoided in cats unless no other treatment options exist. If a reaction occurs, discontinue use of the preparation and treat symptomatically.

The prolonged use of antibiotic containing preparations may result in overgrowth of nonsusceptible organisms including fungi. Appropriate measure should be taken if this occurs. If infection does not respond to treatment in two or three days, the diagnosis and therapy should be reevaluated. Animals under treatment with this product should be observed for the usual signs of corticosteroid overdose, which include polydipsia, polyuria and occasionally an increase in weight.

Care should be taken not to contaminate the applicator tip during administration of the preparation.

All topical ophthalmic preparations containing corticosteroids with or without an antimicrobial are contraindicated in the initial treatment of corneal ulcers. They should not be used until the infection is under control and corneal regeneration is well under way.

Adverse Reactions

Itching, burning or inflammation may occur in animals sensitive to the product. Discontinue use in such cases.


Keep out of reach of children.

STORAGE CONDITIONS: Store between 15°C and 25°C. Keep tightly closed.

Vetoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie (QC) Canada J5T 3S5





3.5 g




12 x 3.5 g




CPN: 1234314.3

Commercial Division

Telephone:   450-586-2252
Order Desk:   800-363-1700
Fax:   450-586-4649
Every effort has been made to ensure the accuracy of the BNPH information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-10-21