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This page contains information on Avimune-Ark for veterinary use.
The information provided typically includes the following:
  • Avimune-Ark Indications
  • Warnings and cautions for Avimune-Ark
  • Direction and dosage information for Avimune-Ark


This treatment applies to the following species:
Manufacturer: Intervet/Schering-Plough Animal Health

U.s. Vet. Lic. No.


Active Ingredient(s)

The vaccine is formulated from the modified DPI strain of Arkansas type infectious bronchitis virus. The virus is grown under exacting standards of quality control in eggs produced by healthy chickens in closely supervised flocks.

Avimune-Ark Indications

Recommended for the vaccination of broilers or the initial vaccination of replacement chickens against the Ark. type of infectious bronchitis. The frequency of occurrence of the various types of infectious bronchitis virus should be considered in planning a vaccination program.

The strain of virus was received from the University of Delaware and was selected for its high immunizing capability and mild reaction.

Avimune-Ark Dosage And Administration

BROILERBRON®-99 is administered by intranasal, intraocular, or drinking water application.

Intranasal Administration:

1. The sterile diluent supplied should be used to reconstitute the vaccine. (See the package insert for complete mixing instructions.)

2. The mixed solution should be stored on ice until used.

3. All of the vaccine should be used within 30 minutes after mixing.

4. To administer, hold the chicks beak shut and place a finger over the lower nostril. Place a full drop of the vaccine on the other nostril. Release the bird after the drop of vaccine has been inhaled.

Intraocular (eye drop) Administration:

1. The sterile diluent supplied should be used to reconstitute the vaccine. (See the package insert for complete mixing instructions.)

2. The mixed solution should be stored on ice until used.

3. All of the vaccine should be used within 30 minutes after mixing.

4. Hold the chicken to be vaccinated with the head tilted to one side giving clear access to one eye.

5. Hold the plastic bottle containing the vaccine in a vertical position. Gently press the sides of the bottle releasing one drop of vaccine onto the eye of the chicken.

6. Be sure that the vaccine spreads over the eye before releasing the chicken. There is usually an automatic reflex action that serves to spread the vaccine over the eye surface as soon as the vaccine is dropped into the eye.

Drinking Water Administration:

1. Remove all medications, sanitizers, and disinfectants from the drinking water, preferably 72 hours before vaccinating, and 24 hours after vaccinating.

2. Provide enough watering space so that at least two-thirds (2/3) of the chickens can drink at one time.

3. Scrub waterers thoroughly and rinse with fresh, clean water.

4. Withhold water for two (2) hours before vaccinating to stimulate thirst. (The time can be varied depending upon climatic conditions.)

5. Waterers should be raised to a height such that the chickens cannot drink and that lends itself to filling the waterers with the vaccine.

6. Rehydrate the vaccine according to the package insert.

7. Add the rehydrated vaccine to clean, cool, nonchlorinated tap water and mix in accordance to the following chart:

Age of Chickens

1,000 doses added to
this amount of water

10,000 doses added to
this amount of water

2-4 wks.

2.5 gal. (9.5 L)

25 gal. (95 L)

4-8 wks.

5 gal. (19 L)

50 gal. (190 L)

Over 8 wks.

10 gal. (38 L)

100 gal. (380 L)

8. Nonfat powdered milk may be beneficial to help maintain the virus. A 3.2 oz. measure is added to each 10 gallons of water used to prepare the vaccine.

9. Distribute the solution among the waterers. Avoid placing the waterers in direct sunlight.

10. Do not provide any other drinking water until all of the vaccine treated water has been consumed.

11. Lower waterers to the correct height so that chickens may drink.

12. It is recommended to walk the chickens after lowering the waterers so that all of the chickens will drink and receive a uniform dose of the vaccine.


Refrigerate under 45°F (7°C) until ready for use. Vaccines are perishable unless properly stored.

Avimune-Ark Caution(s)

The capacity of the vaccine to produce satisfactory results depends upon many factors, including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of individual animals and the degree of field exposure.

Consult a poultry pathologist for further recommendations based on conditions existing in a designated area at any given time.

The vaccination program for replacement pullets should not be started after chickens are 15 weeks of age.

Chickens should not be placed on contaminated premises. Exposure should be avoided immediately after vaccination because it takes up to 10 days to develop resistance.

All susceptible chickens on the same premises should be vaccinated at the same time. If this is not possible, then strict isolation and separate caretakers should be employed for nonvaccinated units. Efforts should be taken to reduce stress conditions at the time the vaccine is administered.

Chickens to be vaccinated should be free of all diseases, including the latent form of chronic respiratory disease (CRD), clinical coccidiosis, blackhead, parasite infestations, etc. and maintained under good environmental conditions.


Do not vaccinate within 21 days of slaughter.


Intranasal or intraocular use: 1,000 dose vials.
Drinking water use: 1,000 and 10,000 dose vials.

Nac No.

29160 INTERVET LANE, P.O. BOX 318, MILLSBORO, DE, 19966-0318
Toll-Free:   800-992-8051
Customer Service:   800-441-8272
Every effort has been made to ensure the accuracy of the Avimune-Ark information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-04-26